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Protein
Submitted name:

Rho GTPase-activating protein 4

Gene

ARHGAP4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Rho GTPase-activating protein 4Imported
Gene namesi
Name:ARHGAP4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000089820.15.
HGNCiHGNC:674. ARHGAP4.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000089820.

PTM / Processingi

Proteomic databases

MaxQBiE9PCM6.
PaxDbiE9PCM6.
PeptideAtlasiE9PCM6.
PRIDEiE9PCM6.

Expressioni

Gene expression databases

BgeeiENSG00000089820.
ExpressionAtlasiE9PCM6. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PCM6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 165F-BARInterPro annotationAdd BLAST147
Domaini329 – 517Rho-GAPInterPro annotationAdd BLAST189
Domaini568 – 627SH3InterPro annotationAdd BLAST60

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili276 – 299Sequence analysisAdd BLAST24

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410INNV. Eukaryota.
ENOG410YF76. LUCA.
GeneTreeiENSGT00760000118863.

Family and domain databases

CDDicd11956. SH3_srGAP4. 1 hit.
Gene3Di1.10.555.10. 1 hit.
InterProiView protein in InterPro
IPR027267. AH/BAR_dom_sf.
IPR031160. F_BAR.
IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR036028. SH3-like_dom_sf.
IPR001452. SH3_domain.
IPR035678. srGAP4_SH3.
PfamiView protein in Pfam
PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
PF00018. SH3_1. 1 hit.
SMARTiView protein in SMART
SM00055. FCH. 1 hit.
SM00324. RhoGAP. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF103657. SSF103657. 1 hit.
SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS51741. F_BAR. 1 hit.
PS50238. RHOGAP. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PCM6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAHGKLRRE RGLQAEYETQ VKEMRWQLSE QLRCLELQGE LRRELLQELA
60 70 80 90 100
EFMRRRAEVE LEYSRGLEKL AERFSSRGGR LGSSREHQSF RKEPSLLSPL
110 120 130 140 150
HCWAVLLQHT RQQSRESAAL SEVLAGPLAQ RLSHIAEDVG RLVKKSRDLE
160 170 180 190 200
QQLQDELLEV VSELQTVAEI CVEMELRDEI LPRAQNIQSR LDRQTIETEE
210 220 230 240 250
VNKTLKATLQ ALLEVVASDD GDVLDSFQTS PSTESLKSTS SDPGSRQAGR
260 270 280 290 300
RRGQQQETET FYLTKLQEYL SGRSILAKLQ AKHEKLQEAL QRGDKEEQEV
310 320 330 340 350
SWTQYTQRKF QKSRQPRPSS QYNQRLFGGD MEKFIQSSGQ PVPLVVESCI
360 370 380 390 400
RFINLNGLQH EGIFRVSGAQ LRVSEIRDAF ERGEDPLVEG CTAHDLDSVA
410 420 430 440 450
GVLKLYFRSL EPPLFPPDLF GELLASSELE ATAERVEHVS RLLWRLPAPV
460 470 480 490 500
LVVLRYLFTF LNHLAQYSDE NMMDPYNLAV CFGPTLLPVP AGQDPVALQG
510 520 530 540 550
RVNQLVQTLI VQPDRVFPPL TSLPGPVYEK CMAPPSASCL GDAQLESLGA
560 570 580 590 600
DNEPELEAEM PAQEDDLEGV VEAVACFAYT GRTAQELSFR RGDVLRLHER
610 620 630 640 650
ASSDWWRGEH NGMRGLIPHK YITLPAGTEK QVVGAGLQTA GESGSSPEGL
660 670 680 690 700
LASELVHRPE PCTSPEAMGP SGHRRRCLVP ASPEQHVEVD KAVAQNMDSV
710 720 730 740 750
FKELLGKTSV RQGLGPASTT SPSPGPRSPK APPSSRLGRN KGFSRGPGAP
760
ASPSASHPQG LDTTPKPH
Length:768
Mass (Da):85,381
Last modified:April 5, 2011 - v1
Checksum:i3870C76CA60B96BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KF510182 Genomic DNA. No translation available.
KF510654 Genomic DNA. No translation available.
KF510656 Genomic DNA. No translation available.
U52112 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000393721; ENSP00000377322; ENSG00000089820.
UCSCiuc065byi.1. human.

Similar proteinsi

Entry informationi

Entry nameiE9PCM6_HUMAN
AccessioniPrimary (citable) accession number: E9PCM6
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported