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Protein
Submitted name:

T-complex protein 1 subunit epsilon

Gene

CCT5

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
T-complex protein 1 subunit epsilonImported
Gene namesi
Name:CCT5Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000150753.11
HGNCiHGNC:1618 CCT5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000150753

PTM / Processingi

Proteomic databases

EPDiE9PCA1
MaxQBiE9PCA1
PeptideAtlasiE9PCA1
PRIDEiE9PCA1

Expressioni

Gene expression databases

BgeeiENSG00000150753
ExpressionAtlasiE9PCA1 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE9PCA1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0357 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074988

Family and domain databases

CDDicd03339 TCP1_epsilon, 1 hit
Gene3Di1.10.560.102 hits
3.30.260.102 hits
3.50.7.101 hit
InterProiView protein in InterPro
IPR012718 Chap_CCT_epsi
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353 PTHR11353, 1 hit
PTHR11353:SF178 PTHR11353:SF178, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02343 chap_CCT_epsi, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

E9PCA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSSLGPTIE KLSVSHIMAA KAVANTMRTS LGPNGLDKMM VDKDGDVTVT
60 70 80 90 100
NDGATILSMM DVDHQIAKLM VELSKSQDDE IGDGTTGVVV LAGALLEEAE
110 120 130 140 150
QLLDRGIHPI RIADGYEQAA RVAIEHLDKI SDSVLVDIKD TEPLIQTAKT
160 170 180 190 200
TLGSKVVNSC HRQMAEIAVN AVLTVADMER RDVDFELIKV EGKVGGRLED
210 220 230 240 250
TKLIKGVIVD KDFSHPQMPK KVEDAKIAIL TCPFEPPKPK TKHKLDVTSV
260 270 280 290 300
EDYKALQKYE KEKFEEMIQQ IKETGANLAI CQWGFDDEAN HLLLQNNLPA
310 320 330 340 350
VRWVGGPEIE LIAIATGGRI VPRFSELTAE KLGFAGLVQE ISFGTTKDKM
360 370 380 390 400
LVIEQCKNSR AVTIFIRGGN KMIIEEAKRS LHDALCVIRN LIRDNRVVYG
410 420 430 440 450
GGAAEISCAL AVSQEADKCP TLEQYAMRAF ADALEVIPMA LSENSGMNPI
460 470 480 490 500
QTMTEVRARQ VKEMNPALGI DCLHKGTNDM KQQHVIETLI GKKQQISLAT
510 520
QMVRMILKID DIRKPGESEE
Length:520
Mass (Da):57,144
Last modified:April 5, 2011 - v1
Checksum:iA9B6DE2A00A57E38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012640 Genomic DNA No translation available.
RefSeqiNP_001293082.1, NM_001306153.1
UniGeneiHs.1600
Hs.740762

Genome annotation databases

EnsembliENST00000503026; ENSP00000423318; ENSG00000150753
GeneIDi22948
UCSCiuc063chf.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PCA1_HUMAN
AccessioniPrimary (citable) accession number: E9PCA1
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported