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Protein

Non-specific serine/threonine protein kinase

Gene

MARK2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiE9PC69.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-specific serine/threonine protein kinaseSAAS annotation (EC:2.7.11.1SAAS annotation)
Gene namesi
Name:MARK2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000072518.20.
HGNCiHGNC:3332. MARK2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000072518.

PTM / Processingi

Proteomic databases

EPDiE9PC69.
MaxQBiE9PC69.
PeptideAtlasiE9PC69.
PRIDEiE9PC69.

Expressioni

Gene expression databases

BgeeiENSG00000072518.
ExpressionAtlasiE9PC69. baseline and differential.

Interactioni

Protein-protein interaction databases

IntActiE9PC69. 5 interactors.

Structurei

3D structure databases

ProteinModelPortaliE9PC69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 304Protein kinaseInterPro annotationAdd BLAST252
Domaini323 – 362UBAInterPro annotationAdd BLAST40
Domaini729 – 778KA1InterPro annotationAdd BLAST50

Phylogenomic databases

eggNOGiKOG0586. Eukaryota.
ENOG410XNQ0. LUCA.
GeneTreeiENSGT00900000140806.

Family and domain databases

InterProiView protein in InterPro
IPR028375. KA1/Ssp2_C.
IPR001772. KA1_dom.
IPR011009. Kinase-like_dom_sf.
IPR033624. MARK/par1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR015940. UBA.
PANTHERiPTHR24346. PTHR24346. 1 hit.
PfamiView protein in Pfam
PF02149. KA1. 1 hit.
PF00069. Pkinase. 1 hit.
PF00627. UBA. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SM00165. UBA. 1 hit.
SUPFAMiSSF103243. SSF103243. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50032. KA1. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50030. UBA. 1 hit.

Sequencei

Sequence statusi: Complete.

E9PC69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSARTPLPT LNERDTEQPT LGHLDSKPSS KSNMIRGRNS ATSADEQPHI
60 70 80 90 100
GNYRLLKTIG KGNFAKVKLA RHILTGKEVA VKIIDKTQLN SSSLQKLFRE
110 120 130 140 150
VRIMKVLNHP NIVKLFEVIE TEKTLYLVME YASGGEVFDY LVAHGRMKEK
160 170 180 190 200
EARAKFRQIV SAVQYCHQKF IVHRDLKAEN LLLDADMNIK IADFGFSNEF
210 220 230 240 250
TFGNKLDTFC GSPPYAAPEL FQGKKYDGPE VDVWSLGVIL YTLVSGSLPF
260 270 280 290 300
DGQNLKELRE RVLRGKYRIP FYMSTDCENL LKKFLILNPS KRGTLEQIMK
310 320 330 340 350
DRWMNVGHED DELKPYVEPL PDYKDPRRTE LMVSMGYTRE EIQDSLVGQR
360 370 380 390 400
YNEVMATYLL LGYKSSELEG DTITLKPRPS ADLTNSSAPS PSHKVQRSVS
410 420 430 440 450
ANPKQRRFSD QAGPAIPTSN SYSKKTQSNN AENKRPEEDR ESGRKASSTA
460 470 480 490 500
KVPASPLPGL ERKKTTPTPS TNSVLSTSTN RSRNSPLLER ASLGQASIQN
510 520 530 540 550
GKDSLTMPGS RASTASASAA VSAARPRQHQ KSMSASVHPN KASGLPPTES
560 570 580 590 600
NCEVPRPSTA PQRVPVASPS AHNISSSGGA PDRTNFPRGV SSRSTFHAGQ
610 620 630 640 650
LRQVRDQQNL PYGVTPASPS GHSQGRRGAS GSIFSKFTSK FVRRNLNEPE
660 670 680 690 700
SKDRVETLRP HVVGSGGNDK EKEEFREAKP RSLRFTWSMK TTSSMEPNEM
710 720 730 740 750
MREIRKVLDA NSCQSELHEK YMLLCMHGTP GHEDFVQWEM EVCKLPRLSL
760 770
NGVRFKRISG TSMAFKNIAS KIANELKL
Length:778
Mass (Da):86,691
Last modified:June 26, 2013 - v3
Checksum:i8170B2136B3F5ACC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003780 Genomic DNA. No translation available.
AP006289 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000502399; ENSP00000423452; ENSG00000072518.
UCSCiuc058cry.1. human.

Similar proteinsi

Entry informationi

Entry nameiE9PC69_HUMAN
AccessioniPrimary (citable) accession number: E9PC69
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: June 26, 2013
Last modified: January 31, 2018
This is version 65 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported