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Protein
Submitted name:

Zinc finger protein with KRAB and SCAN domains 1

Gene

ZKSCAN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
Zinc finger protein with KRAB and SCAN domains 1Imported
Gene namesi
Name:ZKSCAN1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:13101. ZKSCAN1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiE9PC66.
ExpressionAtlasiE9PC66. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323148.

Structurei

3D structure databases

ProteinModelPortaliE9PC66.
SMRiE9PC66. Positions 14-102, 306-508.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains SCAN box domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118881.
KOiK09229.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PC66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWGQDSTLQD TPPPDPEIFR QRFRRFCYQN TFGPREALSR LKELCHQWLR
60 70 80 90 100
PEINTKEQIL ELLVLEQFLS ILPKELQVWL QEYRPDSGEE AVTLLEDLEL
110 120 130 140 150
DLSGQQVPGQ VHGPEMLARG MVPLDPVQES SSFDLHHEAT QSHFKHSSRK
160 170 180 190 200
PRLLQSRALP AAHIPAPPHE GSPRDQAMAS ALFTADSQAM VKIEDMAVSL
210 220 230 240 250
ILEEWGCQNL ARRNLSRDNR QENYGSAFPQ GGENRNENEE STSKAETSED
260 270 280 290 300
SASRGETTGR SQKEFGEKRD QEGKTGERQQ KNPEEKTRKE KRDSGPAIGK
310 320 330 340 350
DKKTITGERG PREKGKGLGR SFSLSSNFTT PEEVPTGTKS HRCDECGKCF
360 370 380 390 400
TRSSSLIRHK IIHTGEKPYE CSECGKAFSL NSNLVLHQRI HTGEKPHECN
410 420 430 440 450
ECGKAFSHSS NLILHQRIHS GEKPYECNEC GKAFSQSSDL TKHQRIHTGE
460 470 480 490 500
KPYECSECGK AFNRNSYLIL HRRIHTREKP YKCTKCGKAF TRSSTLTLHH
510 520
RIHARERASE YSPASLDAFG AFLKSCV
Length:527
Mass (Da):59,675
Last modified:April 5, 2011 - v1
Checksum:iCECD5F79DF559846
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004522 Genomic DNA. No translation available.
AC093619 Genomic DNA. No translation available.
RefSeqiNP_001273983.1. NM_001287054.1.
UniGeneiHs.615360.
Hs.633338.
Hs.743424.

Genome annotation databases

EnsembliENST00000426572; ENSP00000409172; ENSG00000106261.
ENST00000620510; ENSP00000480305; ENSG00000106261.
GeneIDi7586.
KEGGihsa:7586.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004522 Genomic DNA. No translation available.
AC093619 Genomic DNA. No translation available.
RefSeqiNP_001273983.1. NM_001287054.1.
UniGeneiHs.615360.
Hs.633338.
Hs.743424.

3D structure databases

ProteinModelPortaliE9PC66.
SMRiE9PC66. Positions 14-102, 306-508.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323148.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000426572; ENSP00000409172; ENSG00000106261.
ENST00000620510; ENSP00000480305; ENSG00000106261.
GeneIDi7586.
KEGGihsa:7586.

Organism-specific databases

CTDi7586.
HGNCiHGNC:13101. ZKSCAN1.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118881.
KOiK09229.

Miscellaneous databases

ChiTaRSiZKSCAN1. human.
GenomeRNAii7586.
NextBioi35501500.

Gene expression databases

BgeeiE9PC66.
ExpressionAtlasiE9PC66. baseline and differential.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR001909. Krueppel-associated_box.
IPR008916. Retrov_capsid_C.
IPR003309. Tscrpt_reg_SCAN.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 6 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  4. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Ensembl
    Submitted (SEP-2014) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PC66_HUMAN
AccessioniPrimary (citable) accession number: E9PC66
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.