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Protein
Submitted name:

NAD-dependent protein deacetylase sirtuin-1

Gene

SIRT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent protein deacetylase sirtuin-1Imported
Gene namesi
Name:SIRT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:14929. SIRT1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9PC49.
PaxDbiE9PC49.
PeptideAtlasiE9PC49.

Expressioni

Gene expression databases

BgeeiENSG00000096717.
ExpressionAtlasiE9PC49. baseline and differential.
GenevisibleiE9PC49. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000212015.

Structurei

3D structure databases

ProteinModelPortaliE9PC49.
SMRiE9PC49. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 203203Deacetylase sirtuin-typeInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG2684. Eukaryota.
COG0846. LUCA.
GeneTreeiENSGT00740000115330.

Family and domain databases

Gene3Di3.40.50.1220. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 2 hits.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PC49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDIEYFRKD PRPFFKFAKE IYPGQFQPSL CHKFIALSDK EGKLLRNYTQ
60 70 80 90 100
NIDTLEQVAG IQRIIQCHGS FATASCLICK YKVDCEAVRG DIFNQVVPRC
110 120 130 140 150
PRCPADEPLA IMKPEIVFFG ENLPEQFHRA MKYDKDEVDL LIVIGSSLKV
160 170 180 190 200
RPVALIPSSI PHEVPQILIN REPLPHLHFD VELLGDCDVI INELCHRLGG
210 220 230 240 250
EYAKLCCNPV KLSEITEKPP RTQKELAYLS ELPPTPLHVS EDSSSPERTS
260 270 280 290 300
PPDSSVIVTL LDQAAKSNDD LDVSESKGCM EEKPQEVQTS RNVESIAEQM
310 320 330 340 350
ENPDLKNVGS STGEKNERTS VAGTVRKCWP NRVAKEQISR RLDGNQYLFL
360 370 380 390 400
PPNRYIFHGA EVYSDSEDDV LSSSSCGSNS DSGTCQSPSL EEPMEDESEI
410 420 430 440 450
EEFYNGLEDE PDVPERAGGA GFGTDGDDQE AINEAISVKQ EVTDMNYPSN

KS
Length:452
Mass (Da):50,497
Last modified:April 5, 2011 - v1
Checksum:iDADC9A384CCCDD9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133551 Genomic DNA. No translation available.
KF511101 Genomic DNA. No translation available.
RefSeqiNP_001135970.1. NM_001142498.1.
UniGeneiHs.369779.

Genome annotation databases

EnsembliENST00000432464; ENSP00000409208; ENSG00000096717.
GeneIDi23411.
UCSCiuc010qis.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133551 Genomic DNA. No translation available.
KF511101 Genomic DNA. No translation available.
RefSeqiNP_001135970.1. NM_001142498.1.
UniGeneiHs.369779.

3D structure databases

ProteinModelPortaliE9PC49.
SMRiE9PC49. Positions 1-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000212015.

Proteomic databases

EPDiE9PC49.
PaxDbiE9PC49.
PeptideAtlasiE9PC49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000432464; ENSP00000409208; ENSG00000096717.
GeneIDi23411.
UCSCiuc010qis.3. human.

Organism-specific databases

CTDi23411.
HGNCiHGNC:14929. SIRT1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2684. Eukaryota.
COG0846. LUCA.
GeneTreeiENSGT00740000115330.

Miscellaneous databases

GenomeRNAii23411.

Gene expression databases

BgeeiENSG00000096717.
ExpressionAtlasiE9PC49. baseline and differential.
GenevisibleiE9PC49. HS.

Family and domain databases

Gene3Di3.40.50.1220. 2 hits.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR003000. Sirtuin.
IPR026590. Ssirtuin_cat_dom.
[Graphical view]
PANTHERiPTHR11085. PTHR11085. 2 hits.
PfamiPF02146. SIR2. 1 hit.
[Graphical view]
SUPFAMiSSF52467. SSF52467. 1 hit.
PROSITEiPS50305. SIRTUIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PC49_HUMAN
AccessioniPrimary (citable) accession number: E9PC49
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.