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Protein
Submitted name:

NAD-dependent protein deacetylase sirtuin-1

Gene

SIRT1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
NAD-dependent protein deacetylase sirtuin-1Imported
Gene namesi
Name:SIRT1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000096717.11
HGNCiHGNC:14929 SIRT1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000096717

PTM / Processingi

Proteomic databases

EPDiE9PC49
MaxQBiE9PC49
PeptideAtlasiE9PC49
PRIDEiE9PC49

Expressioni

Gene expression databases

BgeeiENSG00000096717
ExpressionAtlasiE9PC49 baseline and differential
GenevisibleiE9PC49 HS

Structurei

3D structure databases

ProteinModelPortaliE9PC49
SMRiE9PC49
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 203Deacetylase sirtuin-typeInterPro annotationAdd BLAST203

Phylogenomic databases

eggNOGiKOG2684 Eukaryota
COG0846 LUCA
GeneTreeiENSGT00870000136443

Family and domain databases

Gene3Di3.30.1600.102 hits
InterProiView protein in InterPro
IPR029035 DHS-like_NAD/FAD-binding_dom
IPR003000 Sirtuin
IPR026591 Sirtuin_cat_small_dom_sf
IPR026590 Ssirtuin_cat_dom
PfamiView protein in Pfam
PF02146 SIR2, 1 hit
SUPFAMiSSF52467 SSF52467, 1 hit
PROSITEiView protein in PROSITE
PS50305 SIRTUIN, 1 hit

Sequencei

Sequence statusi: Complete.

E9PC49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFDIEYFRKD PRPFFKFAKE IYPGQFQPSL CHKFIALSDK EGKLLRNYTQ
60 70 80 90 100
NIDTLEQVAG IQRIIQCHGS FATASCLICK YKVDCEAVRG DIFNQVVPRC
110 120 130 140 150
PRCPADEPLA IMKPEIVFFG ENLPEQFHRA MKYDKDEVDL LIVIGSSLKV
160 170 180 190 200
RPVALIPSSI PHEVPQILIN REPLPHLHFD VELLGDCDVI INELCHRLGG
210 220 230 240 250
EYAKLCCNPV KLSEITEKPP RTQKELAYLS ELPPTPLHVS EDSSSPERTS
260 270 280 290 300
PPDSSVIVTL LDQAAKSNDD LDVSESKGCM EEKPQEVQTS RNVESIAEQM
310 320 330 340 350
ENPDLKNVGS STGEKNERTS VAGTVRKCWP NRVAKEQISR RLDGNQYLFL
360 370 380 390 400
PPNRYIFHGA EVYSDSEDDV LSSSSCGSNS DSGTCQSPSL EEPMEDESEI
410 420 430 440 450
EEFYNGLEDE PDVPERAGGA GFGTDGDDQE AINEAISVKQ EVTDMNYPSN

KS
Length:452
Mass (Da):50,497
Last modified:April 5, 2011 - v1
Checksum:iDADC9A384CCCDD9B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133551 Genomic DNA No translation available.
KF511101 Genomic DNA No translation available.
RefSeqiNP_001135970.1, NM_001142498.1
UniGeneiHs.369779

Genome annotation databases

EnsembliENST00000432464; ENSP00000409208; ENSG00000096717
GeneIDi23411
UCSCiuc010qis.3 human

Similar proteinsi

Entry informationi

Entry nameiE9PC49_HUMAN
AccessioniPrimary (citable) accession number: E9PC49
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported