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Protein
Submitted name:

Gamma-aminobutyric acid receptor subunit alpha-2

Gene

GABRA2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotationSAAS annotation
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Gamma-aminobutyric acid receptor subunit alpha-2Imported
Gene namesi
Name:GABRA2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000151834.15
HGNCiHGNC:4076 GABRA2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei250 – 274HelicalSequence analysisAdd BLAST25
Transmembranei281 – 300HelicalSequence analysisAdd BLAST20
Transmembranei315 – 337HelicalSequence analysisAdd BLAST23
Transmembranei483 – 501HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000151834

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_500324277629 – 511Sequence analysisAdd BLAST483

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiE9PBQ7

Expressioni

Gene expression databases

BgeeiENSG00000151834
ExpressionAtlasiE9PBQ7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliE9PBQ7
SMRiE9PBQ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 249Neur_chan_LBDInterPro annotationAdd BLAST207
Domaini257 – 497Neur_chan_membInterPro annotationAdd BLAST241

Sequence similaritiesi

Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
OMAiQRWKDER
OrthoDBiEOG091G0805
PhylomeDBiE9PBQ7

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR001390 GABAAa_rcpt
IPR005432 GABBAa2_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 2 hits
PTHR18945:SF218 PTHR18945:SF218, 2 hits
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR01079 GABAARALPHA
PR01615 GABAARALPHA2
PR00253 GABAARECEPTR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

E9PBQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTKLNIYNM QFLLFVFLVW DPARLVLANI QEDEAKNNIT IFTRILDRLL
60 70 80 90 100
DGYDNRLRPG LGDSITEVFT NIYVTSFGPV SDTDMEYTID VFFRQKWKDE
110 120 130 140 150
RLKFKGPMNI LRLNNLMASK IWTPDTFFHN GKKSVAHNMT MPNKLLRIQD
160 170 180 190 200
DGTLLYTMRL TVQAECPMHL EDFPMDAHSC PLKFGSYAYT TSEVTYIWTY
210 220 230 240 250
NASDSVQVAP DGSRLNQYDL LGQSIGKETI KSSTGEYTVM TAHFHLKRKI
260 270 280 290 300
GYFVIQTYLP CIMTVILSQV SFWLNRESVP ARTVFGVTTV LTMTTLSISA
310 320 330 340 350
RNSLPKVAYA TAMDWFIAVC YAFVFSALIE FATVNYFTKR GWAWDGKSVV
360 370 380 390 400
NDKSPSIKAE GITLTYNSVK AILQGAKLIW SKYIAFSWPS LFQEKTLEYL
410 420 430 440 450
EKWMDCLTFK QSSKKEKASV MIQNNAYAVA VANYAPNLSK DPVLSTISKS
460 470 480 490 500
ATTPEPNKKP ENKPAEAKKT FNSVSKIDRM SRIVFPVLFG TFNLVYWATY
510
LNREPVLGVS P
Length:511
Mass (Da):58,228
Last modified:April 5, 2011 - v1
Checksum:iFEA49855AE25C20A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC084352 Genomic DNA No translation available.
AC093745 Genomic DNA No translation available.
AC095060 Genomic DNA No translation available.
AC104072 Genomic DNA No translation available.
RefSeqiNP_001317619.1, NM_001330690.1
XP_011511977.1, XM_011513675.1
UniGeneiHs.116250
Hs.48372

Genome annotation databases

EnsembliENST00000507069; ENSP00000427603; ENSG00000151834
GeneIDi2555
UCSCiuc062win.1 human

Similar proteinsi

Entry informationi

Entry nameiE9PBQ7_HUMAN
AccessioniPrimary (citable) accession number: E9PBQ7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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