ID   E9PBI9_HUMAN            Unreviewed;       172 AA.
AC   E9PBI9;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   RecName: Full=Syndecan {ECO:0000256|RuleBase:RU000649};
GN   Name=SDC2 {ECO:0000313|Ensembl:ENSP00000427784.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000427784.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000427784.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
RN   [2] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0007829|PubMed:21406692}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
RN   [4] {ECO:0007829|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000313|Ensembl:ENSP00000427784.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Cell surface proteoglycan. {ECO:0000256|RuleBase:RU000649}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC       ECO:0000256|RuleBase:RU000649}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU000649}.
CC   -!- SIMILARITY: Belongs to the syndecan proteoglycan family.
CC       {ECO:0000256|ARBA:ARBA00005343, ECO:0000256|RuleBase:RU000649}.
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DR   EMBL; AP003477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP003548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011515514.1; XM_011517212.2.
DR   ProteomicsDB; 19235; -.
DR   Antibodypedia; 25987; 311 antibodies from 31 providers.
DR   DNASU; 6383; -.
DR   Ensembl; ENST00000519914.5; ENSP00000428256.1; ENSG00000169439.12.
DR   Ensembl; ENST00000522911.5; ENSP00000427784.1; ENSG00000169439.12.
DR   GeneID; 6383; -.
DR   UCSC; uc011lgu.2; human.
DR   CTD; 6383; -.
DR   HGNC; HGNC:10659; SDC2.
DR   VEuPathDB; HostDB:ENSG00000169439; -.
DR   GeneTree; ENSGT00940000157222; -.
DR   HOGENOM; CLU_046599_2_0_1; -.
DR   OrthoDB; 4258425at2759; -.
DR   BioGRID-ORCS; 6383; 8 hits in 1151 CRISPR screens.
DR   ChiTaRS; SDC2; human.
DR   GenomeRNAi; 6383; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   Bgee; ENSG00000169439; Expressed in tibia and 207 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR001050; Syndecan.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   InterPro; IPR030479; Syndecan_CS.
DR   PANTHER; PTHR10915; SYNDECAN; 1.
DR   PANTHER; PTHR10915:SF6; SYNDECAN-2; 1.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   PROSITE; PS00964; SYNDECAN; 1.
PE   1: Evidence at protein level;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180,
KW   ECO:0000256|RuleBase:RU000649};
KW   Heparan sulfate {ECO:0000256|ARBA:ARBA00023207,
KW   ECO:0000256|RuleBase:RU000649};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteoglycan {ECO:0000256|ARBA:ARBA00022974,
KW   ECO:0000256|RuleBase:RU000649};
KW   Proteomics identification {ECO:0007829|EPD:E9PBI9,
KW   ECO:0007829|MaxQB:E9PBI9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000649};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        116..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          139..157
FT                   /note="Neurexin/syndecan/glycophorin C"
FT                   /evidence="ECO:0000259|SMART:SM00294"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          60..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   172 AA;  18972 MW;  616D44AC7977D6A2 CRC64;
     MYLDNSSIEE ASGVYPIDDD DYASASGSGA DEDVESPELT TSRPLPKILL TSAAPKVETT
     TLNIQNKIPA QTKSPEETDK EKVHLSDSER KMDPAEEDTN VYTEKHSDSL FKRTEVLAAV
     IAGGVIGFLF AIFLILLLVY RMRKKDEGSY DLGERKPSSA AYQKAPTKEF YA
//