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Protein

Syndecan

Gene

SDC2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
SyndecanUniRule annotation
Gene namesi
Name:SDC2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:10659. SDC2.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei116 – 140HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169439.

PTM / Processingi

Keywords - PTMi

Glycoprotein, Heparan sulfateUniRule annotation, Proteoglycan

Proteomic databases

MaxQBiE9PBI9.
PeptideAtlasiE9PBI9.
PRIDEiE9PBI9.

Expressioni

Gene expression databases

BgeeiENSG00000169439.
ExpressionAtlasiE9PBI9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000307046.

Structurei

3D structure databases

ProteinModelPortaliE9PBI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 1574.1mInterPro annotationAdd BLAST19

Sequence similaritiesi

Belongs to the syndecan proteoglycan family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PBI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLDNSSIEE ASGVYPIDDD DYASASGSGA DEDVESPELT TSRPLPKILL
60 70 80 90 100
TSAAPKVETT TLNIQNKIPA QTKSPEETDK EKVHLSDSER KMDPAEEDTN
110 120 130 140 150
VYTEKHSDSL FKRTEVLAAV IAGGVIGFLF AIFLILLLVY RMRKKDEGSY
160 170
DLGERKPSSA AYQKAPTKEF YA
Length:172
Mass (Da):18,972
Last modified:April 5, 2011 - v1
Checksum:i616D44AC7977D6A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003477 Genomic DNA. No translation available.
AP003548 Genomic DNA. No translation available.
KC877279 Genomic DNA. No translation available.
RefSeqiXP_011515514.1. XM_011517212.2.
UniGeneiHs.1501.
Hs.598247.

Genome annotation databases

EnsembliENST00000519914; ENSP00000428256; ENSG00000169439.
ENST00000522911; ENSP00000427784; ENSG00000169439.
GeneIDi6383.
UCSCiuc011lgu.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003477 Genomic DNA. No translation available.
AP003548 Genomic DNA. No translation available.
KC877279 Genomic DNA. No translation available.
RefSeqiXP_011515514.1. XM_011517212.2.
UniGeneiHs.1501.
Hs.598247.

3D structure databases

ProteinModelPortaliE9PBI9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000307046.

Proteomic databases

MaxQBiE9PBI9.
PeptideAtlasiE9PBI9.
PRIDEiE9PBI9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000519914; ENSP00000428256; ENSG00000169439.
ENST00000522911; ENSP00000427784; ENSG00000169439.
GeneIDi6383.
UCSCiuc011lgu.2. human.

Organism-specific databases

CTDi6383.
HGNCiHGNC:10659. SDC2.
OpenTargetsiENSG00000169439.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IW5I. Eukaryota.
ENOG4111QSA. LUCA.
GeneTreeiENSGT00530000063116.

Miscellaneous databases

ChiTaRSiSDC2. human.
GenomeRNAii6383.

Gene expression databases

BgeeiENSG00000169439.
ExpressionAtlasiE9PBI9. baseline and differential.

Family and domain databases

InterProiIPR003585. Neurexin-like.
IPR001050. Syndecan.
IPR031201. Syndecan-2.
IPR027789. Syndecan/Neurexin_dom.
IPR030479. Syndecan_CS.
[Graphical view]
PANTHERiPTHR10915. PTHR10915. 1 hit.
PTHR10915:SF6. PTHR10915:SF6. 1 hit.
PfamiPF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
[Graphical view]
PROSITEiPS00964. SYNDECAN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PBI9_HUMAN
AccessioniPrimary (citable) accession number: E9PBI9
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.