Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Protein-tyrosine kinase 2-beta

Gene

PTK2B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Protein-tyrosine kinase 2-betaImported
Gene namesi
Name:PTK2BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9612. PTK2B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiE9PBI4.
PRIDEiE9PBI4.

Expressioni

Gene expression databases

BgeeiE9PBI4.
ExpressionAtlasiE9PBI4. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PBI4.
SMRiE9PBI4. Positions 2-507.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 105105FERMInterPro annotationAdd
BLAST
Domaini171 – 429259Protein kinaseInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118799.

Family and domain databases

InterProiIPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR030610. PTK2B.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF94. PTHR24418:SF94. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9PBI4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRTALEQQS TLLLFQQGWN ITVDLVIGPK GIRQLTSQDA KPTCLAEFKQ
60 70 80 90 100
IRSIRCLPLE EGQAVLQLGI EGAPQALSIK TSSLAEAENM ADLIDGYCRL
110 120 130 140 150
QGEHQGSLII HPRKDGEKRN SLPQIPMLNL EARRSHLSES CSIESDIYAE
160 170 180 190 200
IPDETLRRPG GPQYGIARED VVLNRILGEG FFGEVYEGVY TNHKGEKINV
210 220 230 240 250
AVKTCKKDCT LDNKEKFMSE AVIMKNLDHP HIVKLIGIIE EEPTWIIMEL
260 270 280 290 300
YPYGELGHYL ERNKNSLKVL TLVLYSLQIC KAMAYLESIN CVHRDIAVRN
310 320 330 340 350
ILVASPECVK LGDFGLSRYI EDEDYYKASV TRLPIKWMSP ESINFRRFTT
360 370 380 390 400
ASDVWMFAVC MWEILSFGKQ PFFWLENKDV IGVLEKGDRL PKPDLCPPVL
410 420 430 440 450
YTLMTRCWDY DPSDRPRFTE LVCSLSDVYQ MEKDIAMEQE RNARYRTPKI
460 470 480 490 500
LEPTAFQEPP PKPSRPKYRP PPQTNLLAPK LQFQEEDFIQ PSSREEAQQL
510 520 530 540 550
WEAEKVKMRQ ILDKQQKQMV EDYQWLRQEE KSLDPMVYMN DKSPLTPEKE
560 570 580 590
VGYRECSRPS SGGFLLAPCA EPPSLPTAQG REQRSLSAFP AASAMI
Length:596
Mass (Da):68,119
Last modified:April 5, 2011 - v1
Checksum:iCD1E3B0F84760DFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010856 Genomic DNA. No translation available.
AC124649 Genomic DNA. No translation available.
AF311103 Genomic DNA. No translation available.
KC877228 Genomic DNA. No translation available.
KF458717 Genomic DNA. No translation available.
KF458718 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000397497; ENSP00000380634; ENSG00000120899.
UCSCiuc003xfr.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010856 Genomic DNA. No translation available.
AC124649 Genomic DNA. No translation available.
AF311103 Genomic DNA. No translation available.
KC877228 Genomic DNA. No translation available.
KF458717 Genomic DNA. No translation available.
KF458718 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PBI4.
SMRiE9PBI4. Positions 2-507.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiE9PBI4.
PRIDEiE9PBI4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397497; ENSP00000380634; ENSG00000120899.
UCSCiuc003xfr.2. human.

Organism-specific databases

HGNCiHGNC:9612. PTK2B.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000118799.

Miscellaneous databases

ChiTaRSiPTK2B. human.
NextBioi35501419.

Gene expression databases

BgeeiE9PBI4.
ExpressionAtlasiE9PBI4. baseline and differential.

Family and domain databases

InterProiIPR000299. FERM_domain.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR030610. PTK2B.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
[Graphical view]
PANTHERiPTHR24418:SF94. PTHR24418:SF94. 1 hit.
PfamiPF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR00109. TYRKINASE.
SMARTiSM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50057. FERM_3. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Glockner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Ensembl
    Submitted (JUL-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiE9PBI4_HUMAN
AccessioniPrimary (citable) accession number: E9PBI4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 11, 2016
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.