ID E9PBC5_HUMAN Unreviewed; 514 AA. AC E9PBC5; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 27-MAY-2015, sequence version 2. DT 27-MAR-2024, entry version 83. DE SubName: Full=Kallikrein B1 {ECO:0000313|Ensembl:ENSP00000424469.2}; GN Name=KLKB1 {ECO:0000313|Ensembl:ENSP00000424469.2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000424469.2, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000424469.2, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., RA Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 and RT 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000313|Ensembl:ENSP00000424469.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AC110771; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001305323.1; NM_001318394.1. DR AlphaFoldDB; E9PBC5; -. DR SMR; E9PBC5; -. DR MassIVE; E9PBC5; -. DR PeptideAtlas; E9PBC5; -. DR ProteomicsDB; 19193; -. DR Antibodypedia; 850; 446 antibodies from 36 providers. DR DNASU; 3818; -. DR Ensembl; ENST00000513864.2; ENSP00000424469.2; ENSG00000164344.17. DR GeneID; 3818; -. DR UCSC; uc011cld.3; human. DR CTD; 3818; -. DR HGNC; HGNC:6371; KLKB1. DR VEuPathDB; HostDB:ENSG00000164344; -. DR GeneTree; ENSGT00940000161669; -. DR OrthoDB; 5292922at2759; -. DR BioGRID-ORCS; 3818; 13 hits in 1154 CRISPR screens. DR ChiTaRS; KLKB1; human. DR GenomeRNAi; 3818; -. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000164344; Expressed in right lobe of liver and 125 other cell types or tissues. DR ExpressionAtlas; E9PBC5; baseline and differential. DR GO; GO:0005576; C:extracellular region; IEA:InterPro. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro. DR GO; GO:0006508; P:proteolysis; IEA:InterPro. DR CDD; cd01100; APPLE_Factor_XI_like; 4. DR CDD; cd00190; Tryp_SPc; 1. DR Gene3D; 3.50.4.10; Hepatocyte Growth Factor; 4. DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1. DR InterPro; IPR000177; Apple. DR InterPro; IPR003609; Pan_app. DR InterPro; IPR009003; Peptidase_S1_PA. DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin. DR InterPro; IPR001314; Peptidase_S1A. DR InterPro; IPR001254; Trypsin_dom. DR InterPro; IPR018114; TRYPSIN_HIS. DR PANTHER; PTHR24252; ACROSIN-RELATED; 1. DR PANTHER; PTHR24252:SF7; HYALIN; 1. DR Pfam; PF00024; PAN_1; 4. DR Pfam; PF00089; Trypsin; 1. DR PRINTS; PR00005; APPLEDOMAIN. DR PRINTS; PR00722; CHYMOTRYPSIN. DR SMART; SM00223; APPLE; 4. DR SMART; SM00020; Tryp_SPc; 1. DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1. DR PROSITE; PS00495; APPLE; 1. DR PROSITE; PS50948; PAN; 3. DR PROSITE; PS50240; TRYPSIN_DOM; 1. DR PROSITE; PS00134; TRYPSIN_HIS; 1. PE 1: Evidence at protein level; KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157}; KW Proteomics identification {ECO:0007829|PeptideAtlas:E9PBC5}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}. FT DOMAIN 73..156 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 163..246 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 254..337 FT /note="Apple" FT /evidence="ECO:0000259|PROSITE:PS50948" FT DOMAIN 353..514 FT /note="Peptidase S1" FT /evidence="ECO:0000259|PROSITE:PS50240" SQ SEQUENCE 514 AA; 57643 MW; 087E8B4DD706F3DA CRC64; MYTPNAQYCQ MRCTFHPRCL LFSFLPASSI NDMEKRFGCF LKDSVTGTLP KVHRTGAVSG HSLKQCGHQI SACHRDIYKG VDMRGVNFNV SKVSSVEECQ KRCTSNIRCQ FFSYATQTFH KAEYRNNCLL KYSPGGTPTA IKVLSNVESG FSLKPCALSE IGCHMNIFQH LAFSDVDVAR VLTPDAFVCR TICTYHPNCL FFTFYTNVWK IESQRNVCLL KTSESGTPSS STPQENTISG YSLLTCKRTL PEPCHSKIYP GVDFGGEELN VTFVKGVNVC QETCTKMIRC QFFTYSLLPE DCKEEKCKCF LRLSMDGSPT RIAYGTQGSS GYSLRLCNTG DNSVCTTKTS TRIVGGTNSS WGEWPWQVSL QVKLTAQRHL CGGSLIGHQW VLTAAHCFDG LPLQDVWRIY SGILNLSDIT KDTPFSQIKE IIIHQNYKVS EGNHDIALIK LQAPLNYTEF QKPICLPSKG DTSTIYTNCW VTGWGFSKEK GRFRWSLSLQ TQWNVAFGGH HQLG //