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Protein

Putative protein PTGES3L

Gene

PTGES3L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Names & Taxonomyi

Protein namesi
Recommended name:
Putative protein PTGES3L
Alternative name(s):
Prostaglandin E synthase 3-like
Gene namesi
Name:PTGES3L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:43943. PTGES3L.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 166166Putative protein PTGES3LPRO_0000418440Add
BLAST

Expressioni

Gene expression databases

BgeeiE9PB15.
ExpressionAtlasiE9PB15. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9PB15.
SMRiE9PB15. Positions 47-121.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 154109CSPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the p23/wos2 family.Curated
Contains 1 CS domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiE9PB15.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: E9PB15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFSLPLNCSP DHIRRGSCWG RPQDLKIAAP AWNSKCHPGA GAAMARQHAR
60 70 80 90 100
TLWYDRPRYV FMEFCVEDST DVHVLIEDHR IVFSCKNADG VELYNEIEFY
110 120 130 140 150
AKVNSKPVWL SVDFDNWRDW EGDEEMELAH VEHYAELLKK VSTKRPPPAM
160
DDLDDDSDSA DDATSN
Length:166
Mass (Da):19,074
Last modified:April 5, 2011 - v1
Checksum:iF960941BA0FC90C1
GO
Isoform 2 (identifier: Q9BTE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q9BTE6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.

Length:525
Mass (Da):58,753
GO
Isoform 3 (identifier: Q9BTE6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry Q9BTE6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.

Length:586
Mass (Da):65,702
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055866 Genomic DNA. No translation available.
RefSeqiNP_001136125.1. NM_001142653.1. [E9PB15-1]
UniGeneiHs.317403.

Genome annotation databases

EnsembliENST00000453594; ENSP00000394415; ENSG00000267060.
GeneIDi100885848.
KEGGihsa:100885848.
UCSCiuc010whh.2. human. [E9PB15-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055866 Genomic DNA. No translation available.
RefSeqiNP_001136125.1. NM_001142653.1. [E9PB15-1]
UniGeneiHs.317403.

3D structure databases

ProteinModelPortaliE9PB15.
SMRiE9PB15. Positions 47-121.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi80755.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000453594; ENSP00000394415; ENSG00000267060.
GeneIDi100885848.
KEGGihsa:100885848.
UCSCiuc010whh.2. human. [E9PB15-1]

Organism-specific databases

CTDi100885848.
GeneCardsiGC17M041120.
HGNCiHGNC:43943. PTGES3L.
neXtProtiNX_E9PB15.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiE9PB15.

Miscellaneous databases

GenomeRNAii100885848.
NextBioi34057621.

Gene expression databases

BgeeiE9PB15.
ExpressionAtlasiE9PB15. baseline and differential.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR007052. CS_dom.
IPR008978. HSP20-like_chaperone.
[Graphical view]
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS51203. CS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPTG3L_HUMAN
AccessioniPrimary (citable) accession number: E9PB15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: April 5, 2011
Last modified: January 7, 2015
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.