E9PB15 (PTG3L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative protein PTGES3L

Alternative name(s):
Prostaglandin E synthase 3-like

Gene names

Name:

PTGES3L

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Sequence similarities	Belongs to the p23/wos2 family. Contains 1 CS domain.
Caution	Product of a dubious gene prediction.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: E9PB15-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9BTE6-2)

The sequence of this isoform can be found in the external entry Q9BTE6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.

Isoform 3 (identifier: Q9BTE6-3)

The sequence of this isoform can be found in the external entry Q9BTE6.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Putative protein PTGES3L		PRO_0000418440
Regions
	Domain	46 – 154	109	CS

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: F960941BA0FC90C1	FASTA	166	19,074
	10 20 30 40 50 60 MFSLPLNCSP DHIRRGSCWG RPQDLKIAAP AWNSKCHPGA GAAMARQHAR TLWYDRPRYV 70 80 90 100 110 120 FMEFCVEDST DVHVLIEDHR IVFSCKNADG VELYNEIEFY AKVNSKPVWL SVDFDNWRDW 130 140 150 160 EGDEEMELAH VEHYAELLKK VSTKRPPPAM DDLDDDSDSA DDATSN
	Isoform 2 [UniParc]. See Q9BTE6.		–	–
	Isoform 3 [UniParc]. See Q9BTE6.		–	–

References

[1]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC055866 Genomic DNA. No translation available.
IPI	IPI00917519.
RefSeq	NP_001136125.1. NM_001142653.1.
UniGene	Hs.317403.
3D structure databases
ProteinModelPortal	E9PB15.
SMR	E9PB15. Positions 47-121.
ModBase	Search...
Protocols and materials databases
DNASU	80755.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000453594; ENSP00000394415; ENSG00000267060.
GeneID	100885848.
KEGG	hsa:100885848.
UCSC	uc010whh.2. human.
Organism-specific databases
CTD	100885848.
GeneCards	GC17M041106.
HGNC	HGNC:43943. PTGES3L.
neXtProt	NX_E9PB15.
GenAtlas	Search...
Gene expression databases
ArrayExpress	E9PB15.
Bgee	E9PB15.
Family and domain databases
InterPro	IPR007052. CS-like_domain. IPR017447. CS_domain. IPR008978. HSP20-like_chaperone. [Graphical view]
Pfam	PF04969. CS. 1 hit. [Graphical view]
SUPFAM	SSF49764. HSP20_chap. 1 hit.
PROSITE	PS51203. CS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	100885848.
NextBio	34057621.

Entry information

Entry name

PTG3L_HUMAN

Accession

Primary (citable) accession number: E9PB15

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2012
Last sequence update:	April 5, 2011
Last modified:	May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.