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E9PB15

- PTG3L_HUMAN

UniProt

E9PB15 - PTG3L_HUMAN

Protein

Putative protein PTGES3L

Gene

PTGES3L

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative protein PTGES3L
    Alternative name(s):
    Prostaglandin E synthase 3-like
    Gene namesi
    Name:PTGES3L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:43943. PTGES3L.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 166166Putative protein PTGES3LPRO_0000418440Add
    BLAST

    Expressioni

    Gene expression databases

    ArrayExpressiE9PB15.
    BgeeiE9PB15.

    Structurei

    3D structure databases

    ProteinModelPortaliE9PB15.
    SMRiE9PB15. Positions 47-121.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 154109CSPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the p23/wos2 family.Curated
    Contains 1 CS domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di2.60.40.790. 1 hit.
    InterProiIPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view]
    SUPFAMiSSF49764. SSF49764. 1 hit.
    PROSITEiPS51203. CS. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: E9PB15-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MFSLPLNCSP DHIRRGSCWG RPQDLKIAAP AWNSKCHPGA GAAMARQHAR    50
    TLWYDRPRYV FMEFCVEDST DVHVLIEDHR IVFSCKNADG VELYNEIEFY 100
    AKVNSKPVWL SVDFDNWRDW EGDEEMELAH VEHYAELLKK VSTKRPPPAM 150
    DDLDDDSDSA DDATSN 166
    Length:166
    Mass (Da):19,074
    Last modified:April 5, 2011 - v1
    Checksum:iF960941BA0FC90C1
    GO
    Isoform 2 (identifier: Q9BTE6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q9BTE6.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.

    Length:525
    Mass (Da):58,753
    GO
    Isoform 3 (identifier: Q9BTE6-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q9BTE6.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

    Note: Based on a readthrough transcript which may produce a PTGES3L-AARSD1 fusion protein. No experimental confirmation available.

    Length:586
    Mass (Da):65,702
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC055866 Genomic DNA. No translation available.
    RefSeqiNP_001136125.1. NM_001142653.1. [E9PB15-1]
    UniGeneiHs.317403.

    Genome annotation databases

    EnsembliENST00000453594; ENSP00000394415; ENSG00000267060. [E9PB15-1]
    GeneIDi100885848.
    KEGGihsa:100885848.
    UCSCiuc010whh.2. human. [E9PB15-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC055866 Genomic DNA. No translation available.
    RefSeqi NP_001136125.1. NM_001142653.1. [E9PB15-1 ]
    UniGenei Hs.317403.

    3D structure databases

    ProteinModelPortali E9PB15.
    SMRi E9PB15. Positions 47-121.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 80755.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000453594 ; ENSP00000394415 ; ENSG00000267060 . [E9PB15-1 ]
    GeneIDi 100885848.
    KEGGi hsa:100885848.
    UCSCi uc010whh.2. human. [E9PB15-1 ]

    Organism-specific databases

    CTDi 100885848.
    GeneCardsi GC17M041120.
    HGNCi HGNC:43943. PTGES3L.
    neXtProti NX_E9PB15.
    GenAtlasi Search...

    Miscellaneous databases

    GenomeRNAii 100885848.
    NextBioi 34057621.

    Gene expression databases

    ArrayExpressi E9PB15.
    Bgeei E9PB15.

    Family and domain databases

    Gene3Di 2.60.40.790. 1 hit.
    InterProi IPR007052. CS_dom.
    IPR008978. HSP20-like_chaperone.
    [Graphical view ]
    SUPFAMi SSF49764. SSF49764. 1 hit.
    PROSITEi PS51203. CS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPTG3L_HUMAN
    AccessioniPrimary (citable) accession number: E9PB15
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2012
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3