ID   E9PAX0_HUMAN            Unreviewed;       231 AA.
AC   E9PAX0;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 70.
DE   SubName: Full=CKLF like MARVEL transmembrane domain containing 1 {ECO:0000313|Ensembl:ENSP00000330061.6};
GN   Name=CMTM1 {ECO:0000313|Ensembl:ENSP00000330061.6};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000330061.6, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000330061.6, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000330061.6}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; AC010542; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_851785.2; NM_181268.2.
DR   AlphaFoldDB; E9PAX0; -.
DR   MassIVE; E9PAX0; -.
DR   MaxQB; E9PAX0; -.
DR   PeptideAtlas; E9PAX0; -.
DR   ProteomicsDB; 19096; -.
DR   Antibodypedia; 2985; 134 antibodies from 20 providers.
DR   DNASU; 113540; -.
DR   Ensembl; ENST00000328020.10; ENSP00000330061.6; ENSG00000089505.18.
DR   GeneID; 113540; -.
DR   UCSC; uc002epn.5; human.
DR   CTD; 113540; -.
DR   HGNC; HGNC:19172; CMTM1.
DR   VEuPathDB; HostDB:ENSG00000089505; -.
DR   GeneTree; ENSGT00940000163203; -.
DR   HOGENOM; CLU_080460_1_0_1; -.
DR   OrthoDB; 4741616at2759; -.
DR   BioGRID-ORCS; 113540; 10 hits in 1141 CRISPR screens.
DR   ChiTaRS; CMTM1; human.
DR   GenomeRNAi; 113540; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000089505; Expressed in left testis and 102 other cell types or tissues.
DR   ExpressionAtlas; E9PAX0; baseline and differential.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008253; Marvel.
DR   PANTHER; PTHR22776:SF43; CKLF-LIKE MARVEL TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR22776; MARVEL-CONTAINING POTENTIAL LIPID RAFT-ASSOCIATED PROTEIN; 1.
DR   PROSITE; PS51225; MARVEL; 1.
DR   Genevisible; E9PAX0; HS.
PE   1: Evidence at protein level;
KW   Membrane {ECO:0000256|PROSITE-ProRule:PRU00581, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:E9PAX0,
KW   ECO:0007829|ProteomicsDB:E9PAX0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00581,
KW   ECO:0000256|SAM:Phobius}; Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        137..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..184
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        196..217
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          131..231
FT                   /note="MARVEL"
FT                   /evidence="ECO:0000259|PROSITE:PS51225"
FT   REGION          1..100
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        63..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        82..96
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   231 AA;  25121 MW;  7A47DB60FB361846 CRC64;
     MDPEHAKPES SEAPSGNLKQ PETAAALASS GSVVSSVPKA QRNISAKTAP RKHPAVSIRS
     AQSAAAARPQ GSEGTAPSRK ATTRPPPKPT LPPPTPSAHT ESKLLNEMAI KERVEGRAKV
     PYKFRDSLKR FSFSPTGMLK ILRLSLILGA LACFIITQAN ESFITITSLE ICIVVFFILI
     YVLTLHHLLT YLHWPLLDLT NSIITAVFLS VVAILAMQEK KRRHLLYVGG R
//