ID E9PAP0_HUMAN Unreviewed; 285 AA. AC E9PAP0; DT 05-APR-2011, integrated into UniProtKB/TrEMBL. DT 05-APR-2011, sequence version 1. DT 27-MAR-2024, entry version 86. DE SubName: Full=LCK proto-oncogene, Src family tyrosine kinase {ECO:0000313|Ensembl:ENSP00000362658.2}; DE Flags: Fragment; GN Name=LCK {ECO:0000313|Ensembl:ENSP00000362658.2}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000362658.2, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000362658.2, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., RA Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., RA Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., RA Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., RA Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., RA Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R., RA Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., RA Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S., RA Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., RA Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., RA Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., RA Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., RA Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., RA Mashreghi-Mohammadi M., Matthews L., Matthews N.S., McLaren S., Milne S., RA Mistry S., Moore M.J., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., RA Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., RA Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., RA Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., RA Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., RA Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., RA Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., RA Coulson A., Vaudin M., Sulston J.E., Durbin R., Hubbard T., Wooster R., RA Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., RA Beck S., Rogers J., Bentley D.R., Banerjee R., Bryant S.P., Burford D.C., RA Burrill W.D., Clegg S.M., Dhami P., Dovey O., Faulkner L.M., Gribble S.M., RA Langford C.F., Pandian R.D., Porter K.M., Prigmore E.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [2] {ECO:0007829|PubMed:19690332} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=19690332; DOI=10.1126/scisignal.2000007; RA Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., RA Rodionov V., Han D.K.; RT "Quantitative phosphoproteomic analysis of T cell receptor signaling RT reveals system-wide modulation of protein-protein interactions."; RL Sci. Signal. 2:RA46-RA46(2009). RN [3] {ECO:0000313|Ensembl:ENSP00000362658.2} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AL109945; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AL121991; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR AlphaFoldDB; E9PAP0; -. DR SMR; E9PAP0; -. DR MassIVE; E9PAP0; -. DR PeptideAtlas; E9PAP0; -. DR ProteomicsDB; 19055; -. DR Antibodypedia; 735; 1855 antibodies from 45 providers. DR Ensembl; ENST00000373557.6; ENSP00000362658.2; ENSG00000182866.18. DR UCSC; uc057ejw.1; human. DR HGNC; HGNC:6524; LCK. DR VEuPathDB; HostDB:ENSG00000182866; -. DR GeneTree; ENSGT00940000161163; -. DR HOGENOM; CLU_978389_0_0_1; -. DR ChiTaRS; LCK; human. DR Proteomes; UP000005640; Chromosome 1. DR Bgee; ENSG00000182866; Expressed in thymus and 143 other cell types or tissues. DR ExpressionAtlas; E9PAP0; baseline and differential. DR GO; GO:0005829; C:cytosol; IEA:UniProt. DR CDD; cd10362; SH2_Src_Lck; 1. DR CDD; cd12005; SH3_Lck; 1. DR Gene3D; 3.30.505.10; SH2 domain; 1. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR043539; Grb2-like. DR InterPro; IPR035850; Lck_SH2. DR InterPro; IPR035749; Lck_SH3. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR46037; PROTEIN ENHANCER OF SEVENLESS 2B; 1. DR PANTHER; PTHR46037:SF6; SRC LIKE ADAPTOR 2; 1. DR Pfam; PF00017; SH2; 1. DR Pfam; PF00018; SH3_1; 1. DR PRINTS; PR00401; SH2DOMAIN. DR PRINTS; PR00452; SH3DOMAIN. DR SMART; SM00252; SH2; 1. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF55550; SH2 domain; 1. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS50001; SH2; 1. DR PROSITE; PS50002; SH3; 1. PE 1: Evidence at protein level; KW Proteomics identification {ECO:0007829|EPD:E9PAP0, KW ECO:0007829|MaxQB:E9PAP0}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}. FT DOMAIN 105..165 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 171..268 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT NON_TER 285 FT /evidence="ECO:0000313|Ensembl:ENSP00000362658.2" SQ SEQUENCE 285 AA; 31628 MW; A1CDB67B50AF41A3 CRC64; MGIPGSHNLR YFWNFPGQGP IISDVGGADL GGAPSAPSSI PSGTMGCGCS SHPEDDWMEN IDVCENCHYP IVPLDGKGTL LIRNGSEVRD PLVTYEGSNP PASPLQDNLV IALHSYEPSH DGDLGFEKGE QLRILEQSGE WWKAQSLTTG QEGFIPFNFV AKANSLEPEP WFFKNLSRKD AERQLLAPGN THGSFLIRES ESTAGSFSLS VRDFDQNQGE VVKHYKIRNL DNGGFYISPR ITFPGLHELV RHYTNASDGL CTRLSRPCQT QKPQKPWWED EWEVP //