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Protein
Submitted name:

Tyrosine-protein kinase Lck

Gene

LCK

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

SignaLinkiE9PAP0.

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosine-protein kinase LckImported
Gene namesi
Name:LCKImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:6524. LCK.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000182866.

PTM / Processingi

Proteomic databases

PaxDbiE9PAP0.
PeptideAtlasiE9PAP0.
PRIDEiE9PAP0.

Expressioni

Gene expression databases

BgeeiENSG00000182866.
ExpressionAtlasiE9PAP0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000337825.

Structurei

3D structure databases

ProteinModelPortaliE9PAP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini105 – 165SH3InterPro annotationAdd BLAST61
Domaini171 – 268SH2InterPro annotationAdd BLAST98

Sequence similaritiesi

Contains 1 SH3 domain.UniRule annotation

Keywords - Domaini

SH3 domainUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

E9PAP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIPGSHNLR YFWNFPGQGP IISDVGGADL GGAPSAPSSI PSGTMGCGCS
60 70 80 90 100
SHPEDDWMEN IDVCENCHYP IVPLDGKGTL LIRNGSEVRD PLVTYEGSNP
110 120 130 140 150
PASPLQDNLV IALHSYEPSH DGDLGFEKGE QLRILEQSGE WWKAQSLTTG
160 170 180 190 200
QEGFIPFNFV AKANSLEPEP WFFKNLSRKD AERQLLAPGN THGSFLIRES
210 220 230 240 250
ESTAGSFSLS VRDFDQNQGE VVKHYKIRNL DNGGFYISPR ITFPGLHELV
260 270 280
RHYTNASDGL CTRLSRPCQT QKPQKPWWED EWEVP
Length:285
Mass (Da):31,628
Last modified:April 5, 2011 - v1
Checksum:iA1CDB67B50AF41A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei285Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109945 Genomic DNA. No translation available.
AL121991 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000373557; ENSP00000362658; ENSG00000182866.
UCSCiuc057ejw.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109945 Genomic DNA. No translation available.
AL121991 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliE9PAP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000337825.

Proteomic databases

PaxDbiE9PAP0.
PeptideAtlasiE9PAP0.
PRIDEiE9PAP0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373557; ENSP00000362658; ENSG00000182866.
UCSCiuc057ejw.1. human.

Organism-specific databases

HGNCiHGNC:6524. LCK.
OpenTargetsiENSG00000182866.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0197. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118938.

Enzyme and pathway databases

SignaLinkiE9PAP0.

Miscellaneous databases

ChiTaRSiLCK. human.

Gene expression databases

BgeeiENSG00000182866.
ExpressionAtlasiE9PAP0. baseline and differential.

Family and domain databases

Gene3Di3.30.505.10. 1 hit.
InterProiIPR000980. SH2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00452. SH3DOMAIN.
SMARTiSM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiE9PAP0_HUMAN
AccessioniPrimary (citable) accession number: E9PAP0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.