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Protein

Cytochrome c oxidase subunit 1

Gene

cox1

Organism
Cyanophora paradoxa
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.UniRule annotation

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.UniRule annotation

Pathwayi: oxidative phosphorylation

This protein is involved in the pathway oxidative phosphorylation, which is part of Energy metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway oxidative phosphorylation and in Energy metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
Biological processElectron transport, Respiratory chainUniRule annotation, Transport
LigandCopperUniRule annotationSAAS annotation, HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1UniRule annotation (EC:1.9.3.1UniRule annotation)
Gene namesi
Name:cox1Imported
Encoded oniMitochondrionImported
OrganismiCyanophora paradoxaImported
Taxonomic identifieri2762 [NCBI]
Taxonomic lineageiEukaryotaGlaucocystophyceaeCyanophoraceaeCyanophora

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 41HelicalSequence analysisAdd BLAST22
Transmembranei61 – 87HelicalSequence analysisAdd BLAST27
Transmembranei108 – 130HelicalSequence analysisAdd BLAST23
Transmembranei150 – 175HelicalSequence analysisAdd BLAST26
Transmembranei187 – 214HelicalSequence analysisAdd BLAST28
Transmembranei234 – 258HelicalSequence analysisAdd BLAST25
Transmembranei270 – 294HelicalSequence analysisAdd BLAST25
Transmembranei306 – 329HelicalSequence analysisAdd BLAST24
Transmembranei341 – 360HelicalSequence analysisAdd BLAST20
Transmembranei380 – 399HelicalSequence analysisAdd BLAST20
Transmembranei411 – 436HelicalSequence analysisAdd BLAST26
Transmembranei456 – 476HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE9P1F2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 525COX1InterPro annotationAdd BLAST518

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Family and domain databases

CDDicd01663. Cyt_c_Oxidase_I. 1 hit.
Gene3Di1.20.210.10. 1 hit.
InterProiView protein in InterPro
IPR023616. Cyt_c_oxase-like_su1_dom.
IPR036927. Cyt_c_oxase-like_su1_sf.
IPR000883. Cyt_C_Oxase_1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR033944. Cyt_c_oxase_su1_dom.
IPR014241. Cyt_c_oxidase_su1_bac.
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiView protein in Pfam
PF00115. COX1. 1 hit.
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
TIGRFAMsiTIGR02891. CtaD_CoxA. 1 hit.
PROSITEiView protein in PROSITE
PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.

Sequencei

Sequence statusi: Complete.

E9P1F2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDAFIHRWLY STNHKDIGTL YLVFGAFSGL LGTAFSFLIR LELANPGNQI
60 70 80 90 100
LAGNHQLYNV IVTAHAFIMV FFMVMPVLIG GFGNWFVPIM IGAPDMAFPR
110 120 130 140 150
LNNISFWVLP PSLLLLTVSA LVETGAGTGW TVYPPLAAIQ GHSSASVDLA
160 170 180 190 200
IFSLHLSGAG SILGAVNFIS TIFNMRALGL KMHQLPLFVW AILITAFLLL
210 220 230 240 250
LSLPVFAGAL TMLLTDRNFN TTFFDPAGGG DPILYQHLFW FFGHPEVYIL
260 270 280 290 300
IIPGFGIISH VISTFSNKPV FGYLGMVYAM LSIGILGFIV WAHHMYTVGL
310 320 330 340 350
DVDTRAYFTA ATMIIAVPTG IKIFSWIATM WGGSIVLHTP MLFAVGFILL
360 370 380 390 400
FTIGGLTGIV LSNSGLDIAF HDTYYVVGHF HYVLSMGAVF AMFAGFYYWI
410 420 430 440 450
GKISGLKYPE LLGKIHFFST FIGVNMTFFP MHFLGLAGMP RRIPDYPDAF
460 470 480 490 500
AGWNAVASYG SYISVVSAIF FFYVVYKTLT SGEPCENNPW VFDEKKGNNK
510 520 530
QSHNIEWVLS SPVQTHLFEE LPIIPVKVKK KKN
Length:533
Mass (Da):58,926
Last modified:April 5, 2011 - v1
Checksum:i560CCDEA36A58D6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HQ849544 Genomic DNA. Translation: ADW79204.1.
RefSeqiYP_006280850.1. NC_017836.1.

Genome annotation databases

GeneIDi12486721.

Similar proteinsi

Entry informationi

Entry nameiE9P1F2_CYAPA
AccessioniPrimary (citable) accession number: E9P1F2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 28, 2018
This is version 35 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)