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E9NME8 (E9NME8_HORSE) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cellular tumor antigen p53 RuleBase RU003304
OrganismEquus caballus (Horse) EMBL ADV57293.1
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus ›

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subunit structure

Binds DNA as a homotetramer By similarity.

Subcellular location

Cytoplasm. Nucleus By similarity.

Sequence similarities

Belongs to the p53 family. RuleBase RU003401

Sequences

Sequence LengthMass (Da)Tools
E9NME8 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: F9B7BAB57C8C1697

FASTA38142,403
        10         20         30         40         50         60 
MEETQTELGI EPPLSQETFS DLWKLLPENN VLSPDLSPAV NNLLLSPDVV NWLDEGPDEA 

        70         80         90        100        110        120 
PRMPAAPAPL APAPATSWPL SSFVPSQKTY PGCYGFRLGF LNSGTAKSVT CTYSPTLNKL 

       130        140        150        160        170        180 
FCQLAKTCPV QLLVSSPPPP GTRVRAMAIY KKSEFMTEVV RRCPHHERCS DSSDGLAPPQ 

       190        200        210        220        230        240 
HLIRVEGNLR AEYLEDRNTF RHSVVVPYEP PEVGSDCTTI HYNFMCNSSC MGGMNRRPIL 

       250        260        270        280        290        300 
TIITLEDSSG NLLGRNSFEV RVCACPGRDR RTEEENFRKK EEPCPEPPPR STKRVLSSNT 

       310        320        330        340        350        360 
SSSPPQKKKP LDGEYFTLQI RGRERFEMFR ELNEALELKD AQTGKEPGGS KAHSSHLKSK 

       370        380 
KGQSTSSHKK LIFKREGPDS D

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References

[1]Yuan Z., Gault E.A., Finlay M., Campo S.M., Nasir L.
Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		HQ677022 mRNA. Translation: ADV57293.1.
RefSeqNP_001189334.1. NM_001202405.1.
UniGeneEca.16089.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100062044.
KEGGecb:100062044.

Organism-specific databases

CTD7157.

Phylogenomic databases

KOK04451.

Family and domain databases

Gene3D2.60.40.720. 1 hit.
4.10.170.10. 1 hit.
InterProIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA-bd.
IPR011615. p53_DNA-bd.
IPR010991. p53_tetrameristn.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_suppressor.
[Graphical view]
PANTHERPTHR11447. PTHR11447. 1 hit.
PfamPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
PF07710. P53_tetramer. 1 hit.
[Graphical view]
PRINTSPR00386. P53SUPPRESSR.
SUPFAMSSF49417. P53_like_DNA_bnd. 1 hit.
SSF47719. p53_tetrameristn. 1 hit.
PROSITEPS00348. P53. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE9NME8_HORSE
AccessionPrimary (citable) accession number: E9NME8
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 6, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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