POU5F1P4

Functionⁱ

GO - Molecular functionⁱ

sequence-specific DNA binding Source: InterPro
transcription factor activity, sequence-specific DNA binding Source: UniProtKB-UniRule

GO - Biological processⁱ

transcription, DNA-templated Source: UniProtKB-UniRule

Keywordsⁱ

Molecular function	DNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological process	Transcription, Transcription regulationPROSITE-ProRule annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: POU domain proteinUniRule annotation
Gene namesⁱ	Name:POU5F1P4Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

Nucleus
PROSITE-ProRule annotation
Automatic assertion according to rulesⁱ
- PROSITE-ProRule:PRU00530
- RuleBase:RU000682
SAAS annotation
Automatic assertion according to rulesⁱ
- SAAS:SAAS00553137

GO - Cellular componentⁱ

nucleus Source: UniProtKB-SubCell

Complete GO annotation...

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

PTM / Processingⁱ

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	E9LR91.

PeptideAtlasⁱ

E9LR91.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	131 – 205	POU-specificInterPro annotationAdd BLAST		75
Domainⁱ	221 – 281	Homeobox DNA-bindingInterPro annotationAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the POU transcription factor family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

HomeoboxUniRule annotationSAAS annotation

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom. IPR013847. POU. IPR000327. POU_dom. IPR015585. POU_dom_5.
PANTHERⁱ	PTHR11636:SF100. PTHR11636:SF100. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit.
PRINTSⁱ	PR00028. POUDOMAIN.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit. SM00352. POU. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

E9LR91-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPAFLPPPGG GGDGPGGPEP GWVDPRTWLS FQGPPGGPGI GPGVGSGSEV 
        60         70         80         90        100
WGIPPCPPLY EFCGGMAYCG PQVGVRLVPQ GGLETSQPEG EAGVRVESNS 
       110        120        130        140        150
DGTSLEPCTV PPGAVKLEKE KLEQNPQESQ NIKALQKELE QFAKLLKQKR 
       160        170        180        190        200
ITLGYTQADV GHTLGVLFGK VFSQTTICRF EGLQLSFKNM CKLRPLLQKW 
       210        220        230        240        250
VEEADNNENL QETCKAETLL QARKRKRTSI ENRVRGSLEN LFLQCPKPTL 
       260        270        280 
QQISHIAQQL GLEKDVVRVW FCNRCQKGKQ SSSDYA

Length:286

Mass (Da):31,156

Last modified:April 5, 2011 - v1

Checksum:ⁱA25496929EDBA514

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ122682 mRNA. Translation: ADW77331.1.
UniGeneⁱ	Hs.632482.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	HQ122682 mRNA. Translation: ADW77331.1.
UniGeneⁱ	Hs.632482.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	E9LR91.

PeptideAtlasⁱ

E9LR91.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Family and domain databases

InterProⁱ	View protein in InterPro IPR009057. Homeobox-like. IPR017970. Homeobox_CS. IPR001356. Homeobox_dom. IPR010982. Lambda_DNA-bd_dom. IPR013847. POU. IPR000327. POU_dom. IPR015585. POU_dom_5.
PANTHERⁱ	PTHR11636:SF100. PTHR11636:SF100. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046. Homeobox. 1 hit. PF00157. Pou. 1 hit.
PRINTSⁱ	PR00028. POUDOMAIN.
SMARTⁱ	View protein in SMART SM00389. HOX. 1 hit. SM00352. POU. 1 hit.
SUPFAMⁱ	SSF46689. SSF46689. 1 hit. SSF47413. SSF47413. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00035. POU_1. 1 hit. PS00465. POU_2. 1 hit. PS51179. POU_3. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	E9LR91_HUMAN
Accessionⁱ	E9LR91Primary (citable) accession number: E9LR91
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	April 5, 2011
	Last sequence update:	April 5, 2011
	Last modified:	July 5, 2017
	This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - E9LR91 (E9LR91_HUMAN)

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POU domain protein

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Proteomic databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Keywords - Domainⁱ

Family and domain databases

Sequenceⁱ

Sequence databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - E9LR91 (E9LR91_HUMAN)

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POU domain protein

POU5F1P4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ