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Protein
Submitted name:

Epididymis secretory sperm binding protein Li 44a

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. endopeptidase inhibitor activity Source: Ensembl

GO - Biological processi

  1. inflammatory response Source: Ensembl
  2. negative regulation of serine-type endopeptidase activity Source: Ensembl
  3. response to chromate Source: Ensembl
  4. response to cytokine Source: Ensembl
  5. response to estradiol Source: Ensembl
  6. response to hypoxia Source: Ensembl
  7. response to lead ion Source: Ensembl
  8. response to lipopolysaccharide Source: Ensembl
  9. response to methanol Source: Ensembl
  10. response to triglyceride Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Epididymis secretory sperm binding protein Li 44aImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiE9KL23.

Expressioni

Gene expression databases

BgeeiE9KL23.
ExpressionAtlasiE9KL23. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE9KL23.
SMRiE9KL23. Positions 48-417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.UniRule annotation

Phylogenomic databases

KOiK03984.
OMAiGKWERPF.
PhylomeDBiE9KL23.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9KL23-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSSVSWGIL LLAGLCCLVP VSLAEDPQGD AAQKTDTSHH DQDHPTFNKI
60 70 80 90 100
TPNLAEFAFS LYRQLAHQSN STNIFFSPVS IATAFAMLSL GTKADTHDEI
110 120 130 140 150
LEGLNFNLTE IPEAQIHEGF QELLRTLNQP DSQLQLTTGN GLFLSEGLKL
160 170 180 190 200
VDKFLEDVKK LYHSEAFTVN FGDTEEAKKQ INDYVEKGTQ GKIVDLVKEL
210 220 230 240 250
DRDTVFALVN YIFFKGKWER PFEVKDTEEE DFHVDQVTTV KVPMMKRLGM
260 270 280 290 300
FNIQHCKKLS SWVLLMKYLG NATAIFFLPD EGKLQHLENE LTHDIITKFL
310 320 330 340 350
ENEDRRSASL HLPKLSITGT YDLKSVLGQL GITKVFSNGA DLSGVTEEAP
360 370 380 390 400
LKLSKAVHKA VLTIDEKGTE AAGAMFLEAI PMSIPPEVKF NKPFVFLMIE
410
QNTKSPLFMG KVVNPTQK
Length:418
Mass (Da):46,737
Last modified:April 5, 2011 - v1
Checksum:i7016555F273B7F16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727620 mRNA. Translation: ADU87622.1.
RefSeqiNP_000286.3. NM_000295.4.
NP_001002235.1. NM_001002235.2.
NP_001002236.1. NM_001002236.2.
NP_001121172.1. NM_001127700.1.
NP_001121173.1. NM_001127701.1.
NP_001121174.1. NM_001127702.1.
NP_001121175.1. NM_001127703.1.
NP_001121176.1. NM_001127704.1.
NP_001121177.1. NM_001127705.1.
NP_001121178.1. NM_001127706.1.
NP_001121179.1. NM_001127707.1.
UniGeneiHs.525557.

Genome annotation databases

GeneIDi5265.
KEGGihsa:5265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU727620 mRNA. Translation: ADU87622.1.
RefSeqiNP_000286.3. NM_000295.4.
NP_001002235.1. NM_001002235.2.
NP_001002236.1. NM_001002236.2.
NP_001121172.1. NM_001127700.1.
NP_001121173.1. NM_001127701.1.
NP_001121174.1. NM_001127702.1.
NP_001121175.1. NM_001127703.1.
NP_001121176.1. NM_001127704.1.
NP_001121177.1. NM_001127705.1.
NP_001121178.1. NM_001127706.1.
NP_001121179.1. NM_001127707.1.
UniGeneiHs.525557.

3D structure databases

ProteinModelPortaliE9KL23.
SMRiE9KL23. Positions 48-417.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiE9KL23.

Protocols and materials databases

DNASUi5265.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5265.
KEGGihsa:5265.

Organism-specific databases

CTDi5265.

Phylogenomic databases

KOiK03984.
OMAiGKWERPF.
PhylomeDBiE9KL23.

Miscellaneous databases

GenomeRNAii5265.
NextBioi20336.

Gene expression databases

BgeeiE9KL23.
ExpressionAtlasiE9KL23. baseline and differential.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."
    Li J., Liu F., Wang H., Liu X., Liu J., Li N., Wan F., Wang W., Zhang C., Jin S., Liu J., Zhu P., Liu Y.
    Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Li J.Y.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiE9KL23_HUMAN
AccessioniPrimary (citable) accession number: E9KL23
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.