ID   E9GME3_DAPPU            Unreviewed;       474 AA.
AC   E9GME3;
DT   05-APR-2011, integrated into UniProtKB/TrEMBL.
DT   05-APR-2011, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Argininosuccinate lyase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=DAPPUDRAFT_304871 {ECO:0000313|EMBL:EFX79352.1};
OS   Daphnia pulex (Water flea).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC   Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX   NCBI_TaxID=6669 {ECO:0000313|EMBL:EFX79352.1, ECO:0000313|Proteomes:UP000000305};
RN   [1] {ECO:0000313|EMBL:EFX79352.1, ECO:0000313|Proteomes:UP000000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21292972; DOI=10.1126/science.1197761;
RA   Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A.,
RA   Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J.,
RA   Caceres C.E., Carmel L., Casola C., Choi J.H., Detter J.C., Dong Q.,
RA   Dusheyko S., Eads B.D., Frohlich T., Geiler-Samerotte K.A., Gerlach D.,
RA   Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D.,
RA   Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J.,
RA   Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M.,
RA   Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y.,
RA   Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H.,
RA   Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R.,
RA   Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P.,
RA   Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L.;
RT   "The ecoresponsive genome of Daphnia pulex.";
RL   Science 331:555-561(2011).
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000256|ARBA:ARBA00010755}.
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DR   EMBL; GL732552; EFX79352.1; -; Genomic_DNA.
DR   AlphaFoldDB; E9GME3; -.
DR   STRING; 6669.E9GME3; -.
DR   EnsemblMetazoa; EFX79352; EFX79352; DAPPUDRAFT_304871.
DR   KEGG; dpx:DAPPUDRAFT_304871; -.
DR   eggNOG; KOG1316; Eukaryota.
DR   HOGENOM; CLU_027272_2_1_1; -.
DR   InParanoid; E9GME3; -.
DR   OMA; DFAIEFC; -.
DR   PhylomeDB; E9GME3; -.
DR   Proteomes; UP000000305; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IBA:GO_Central.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IBA:GO_Central.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.10.40.30; Fumarase/aspartase (C-terminal domain); 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00838; argH; 1.
DR   PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 1.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000305}.
FT   DOMAIN          17..307
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          370..437
FT                   /note="Argininosuccinate lyase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14698"
SQ   SEQUENCE   474 AA;  53017 MW;  B15B2522AAA66799 CRC64;
     MEESGGKLWG GRFSDRRVDQ VMERFNSSIS YDKRLCYVDI LGSKAYAAGL FKAGLVDQLE
     CADICNALSA IEDEWRNETF EILPSDEDIH SANERRLKEM IGMAGGKLHT GRSRNDQVAT
     DLRLWLRQEI DQSLDKFLVQ IIQILIERAQ DEMDILLPGY THLQRAQPIR WSHYLCSYAW
     SLWSDVQRLI QLRDRVNVMP LGSGALAGSP FPIDRLYLSD LLGFDNITPN SLLGVGDRDF
     VVEFLSWASI LSSHLSRLAE DLIIYSTKEF NFVTIADAYS TGSSLMPQKR NPDGLELIRA
     KAGRIFGHMA GFSMVLKGLP STYNKDLQED KEALFDVVDN LYVSLQVAAG ILSTLKITAE
     RAMGALSSDM LATDLAYHLV RRGVAFREAH AIVGKVVSMA EDQQKEMSDL TLEELQTVSS
     AFDSSVASIW NYEHSVEQYQ VAGGTSRRAV QKQIDDLKAL LELRNIPTAS STAL
//