E9GCV2 (E9GCV2_DAPPU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase RuleBase RU003929
EC=1.7.1.7 RuleBase RU003929

Gene names

ORF Names:

DAPPUDRAFT_210496 EMBL EFX82619.1

Organism

Daphnia pulex (Water flea) [Reference proteome]

Taxonomic identifier

6669 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Crustacea › Branchiopoda › Phyllopoda › Diplostraca › Cladocera › Anomopoda › Daphniidae › Daphnia

Protein attributes

Sequence length	351 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. RuleBase RU003929
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. RuleBase RU003929
Sequence similarities	Belongs to the IMPDH/GMPR family. RuleBase RU003927

Ontologies

Keywords
Ligand	Metal-binding RuleBase RU003929 NADP RuleBase RU003929 Potassium RuleBase RU003929
Molecular function	Oxidoreductase RuleBase RU003927
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nucleotide metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	GMP reductase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	E9GCV2 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 1C4314E35F73D865	FASTA	351	37,796
	10 20 30 40 50 60 MPRIDNDVKL DFKDVLLRPK RSTLKSRADV DLFREIKFRN SKQTIRGIPI IASNMDTVGT 70 80 90 100 110 120 FEMASALAKH GLLTTIHKHY QVEEWVNFMQ KNKDVAGFVA ASSGSGKGDF EKLSKILNAV 130 140 150 160 170 180 PEVRFVCLDV ANGYSEHFVE FVRSVREAFP QHVIMAGNVV TGEMVEELIL SGADIIKVGI 190 200 210 220 230 240 GPGSVCTTRK KTGVGYPQIS AVIECADAAH GLGGHIISDG GCTCPGDVAK AFGAGADFVM 250 260 270 280 290 300 LGGMLSGHDQ SGGDVIERDG KKYKLFYGMS SATAMNKHVG GVSEYRASEG KTVEVPYRGN 310 320 330 340 350 VDATISDILG GLRSACTYTG AARLKELPKR TTFIRVTQQT NEIFSAFSSG D

References

[1]

"The ecoresponsive genome of Daphnia pulex." Colbourne J.K., Pfrender M.E., Gilbert D., Thomas W.K., Tucker A., Oakley T.H., Tokishita S., Aerts A., Arnold G.J., Basu M.K., Bauer D.J., Caceres C.E., Carmel L., Casola C., Choi J.-H., Detter J.C., Dong Q., Dusheyko S. , Eads B.D., Frohlich T., Geiler-samerotte K.A., Gerlach D., Hatcher P., Jogdeo S., Krijgsveld J., Kriventseva E.V., Kultz D., Laforsch C., Lindquist E., Lopez J., Manak J.R., Muller J., Pangilinan J., Patwardhan R.P., Pitluck S., Pritham E.J., Rechtsteiner A., Rho M., Rogozin I.B., Sakarya O., Salamov A., Schaack S., Shapiro H., Shiga Y., Skalitzky C., Smith Z., Souvorov A., Sung W., Tang Z., Tsuchiya D., Tu H., Vos H., Wang M., Wolf Y.I., Yamagata H., Yamada T., Ye Y., Shaw J.R., Andrews J., Crease T.J., Tang H., Lucas S.M., Robertson H.M., Bork P., Koonin E.V., Zdobnov E.M., Grigoriev I.V., Lynch M., Boore J.L. Science 331:555-561(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	GL732539 Genomic DNA. Translation: EFX82619.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
OMA	CSCAGDV.
PhylomeDB	E9GCV2.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR005993. GMP_reduct1. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF000235. GMP_reductase. 1 hit.
TIGRFAMs	TIGR01305. GMP_reduct_1. 1 hit.
PROSITE	PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

E9GCV2_DAPPU

Accession

Primary (citable) accession number: E9GCV2

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)