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Protein

Endochitinase 2

Gene

chi2

Organism
Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Secreted chitinase involved in the degradation of chitin, a component of the cell walls of fungi and exoskeletal elements of some animals (including worms and arthropods). Participates in the infection process and directly acts in the penetration process of the host cuticle (By similarity).By similarity

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei173Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation, Virulence
LigandChitin-binding

Protein family/group databases

CAZyiGH18. Glycoside Hydrolase Family 18.

Names & Taxonomyi

Protein namesi
Recommended name:
Endochitinase 2 (EC:3.2.1.14)
Alternative name(s):
Chitinase 2
Gene namesi
Name:chi2
ORF Names:MAA_09018
OrganismiMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Taxonomic identifieri655844 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaeMetarhizium
Proteomesi
  • UP000002498 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000042986719 – 419Endochitinase 2Add BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi153N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi237N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi256N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

SMRiE9F9R9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini383 – 419CBM1PROSITE-ProRule annotationAdd BLAST37

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

KOiK01183.
OrthoDBiEOG092C49QH.

Family and domain databases

InterProiView protein in InterPro
IPR035971. CBD_sf.
IPR000254. Cellulose-bd_dom_fun.
IPR001223. Glyco_hydro18_cat.
IPR001579. Glyco_hydro_18_chit_AS.
IPR017853. Glycoside_hydrolase_SF.
PfamiView protein in Pfam
PF00734. CBM_1. 1 hit.
PF00704. Glyco_hydro_18. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001821. CBD_fun. 1 hit.
SMARTiView protein in SMART
SM00236. fCBD. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF57180. SSF57180. 1 hit.
PROSITEiView protein in PROSITE
PS51164. CBM1_2. 1 hit.
PS01095. CHITINASE_18. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9F9R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHLRALVGV GLAGLAAGVP LTDKISVKPR QAPGAQNVVY WGQNGGGTIE
60 70 80 90 100
NNDLAAYCQP NSGIDVLVLA FLYQFGNGGN IPSGTIGQSC YISTSGQGQN
110 120 130 140 150
CEALTAAIHT CQSAGVKIIL SLGGATSSYS LQTQAQAEQI GQYLWDSYGN
160 170 180 190 200
SGNKTVQRPF GSNFVNGFDF DIEVNGGSSQ YYQYMIAKLR SNFASDKSNT
210 220 230 240 250
YLITGAPQCP IPEPNMGVII SNSVFDHLYV QFYNNNNYTV PCALGINGNA
260 270 280 290 300
PFNYNNWTSF IADTPSAGAK IFIGVPASPL ASTGTPSGAQ YYAAPDQLAA
310 320 330 340 350
IVGEYRSDAH FGGIMMWSAG FSDANVNNGC TYAQQAKSIL VNGAPCASSG
360 370 380 390 400
PPSSTPATAP APTATTMPSS TSVSSPAASP TGGTVPQWGQ CGGEGYSGPT
410
QCVAPYQCVK QGDWWSSCR
Length:419
Mass (Da):43,619
Last modified:March 4, 2015 - v2
Checksum:i9C8BB689E70EFB3B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADNJ02000006 Genomic DNA. Translation: EFY95562.2.
RefSeqiXP_007825207.2. XM_007827016.2.

Genome annotation databases

EnsemblFungiiEFY95562; EFY95562; MAA_09018.
GeneIDi19263304.
KEGGimaj:MAA_09018.

Similar proteinsi

Entry informationi

Entry nameiCHI2_METRA
AccessioniPrimary (citable) accession number: E9F9R9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: March 4, 2015
Last modified: October 25, 2017
This is version 33 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families