E9F9J8 (AMPP2_METAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase MAA_08947
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

MAA_08947

Organism

Metarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075) [Complete proteome]

Taxonomic identifier

655844 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › mitosporic Clavicipitaceae › Metarhizium › Metarhizium anisopliae

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Probable Xaa-Pro aminopeptidase MAA_08947		PRO_0000411838
Sites
	Metal binding	257	1	Manganese 2 By similarity
	Metal binding	268	1	Manganese 1 By similarity
	Metal binding	268	1	Manganese 2 By similarity
	Metal binding	421	1	Manganese 1 By similarity
	Metal binding	462	1	Manganese 1 By similarity
	Metal binding	462	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E9F9J8 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 5BA28DC825291B34	FASTA	493	53,742
	10 20 30 40 50 60 MTRLQRPNIL VRLATQSPNS SWQASSPALS TMRNFLLLPI LPPSAPHEAN TGNPPPRSFF 70 80 90 100 110 120 YITGANFEDC TATYEVKHDK LTLWIPYVEP RQVLWFGSKP SAAECKRRYD VDEVRYTTQL 130 140 150 160 170 180 SGFLRSFAAQ PSPPVTYILH PKQAPDLGHG SQSQLCLDSS LLLPAMDRAR VVKSDYEVAM 190 200 210 220 230 240 VRRANNISSA AHRRVAERIL RLTNEREIEA IIQAVCIASG SRSQAYPIIA GSGANGATLH 250 260 270 280 290 300 YGSNNASLGG KQCVVIDAGC EWNCYASDIT RTLPLSGAWT PKAAAIHAIV QRMQDECIAK 310 320 330 340 350 360 VGPGAAWREI HLHAASVGME GLLGLGILKG RREDVARAGT VAAFFPHGLG HHVGLDVHDV 370 380 390 400 410 420 SGTLALSAAE GRGQQLDFGK RAMVTPSMLA DMTRVSSSQD AVGGGQSKTQ LLLPNMIVTV 430 440 450 460 470 480 EPGIYFCREY LEGYFRSDPA HADFIDWDLL EEYYDVGGVR IEDCILVTED GYENLTVAPK 490 GDELLDVINK GKK

References

[1]

"Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum." Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J. , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C. PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ARSEF 23 / ATCC MYA-3075.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GL698739 Genomic DNA. Translation: EFY95651.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.230.10. 2 hits.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_METAR

Accession

Primary (citable) accession number: E9F9J8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program