E9EUE6 (AMPP1_METAR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	MAA_03645

Organism

Metarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075) [Complete proteome]

Taxonomic identifier

655844 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › mitosporic Clavicipitaceae › Metarhizium › Metarhizium anisopliae

Protein attributes

Sequence length	618 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 618	618	Probable Xaa-Pro aminopeptidase P		PRO_0000411796
Sites
	Metal binding	414	1	Manganese 2 By similarity
	Metal binding	425	1	Manganese 1 By similarity
	Metal binding	425	1	Manganese 2 By similarity
	Metal binding	523	1	Manganese 1 By similarity
	Metal binding	537	1	Manganese 1 By similarity
	Metal binding	537	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E9EUE6 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: F2A35382C2C7C39E	FASTA	618	67,996
	10 20 30 40 50 60 MADSSPQLAK LRSLMKERKV HVYVIPSEDS HSSEYIAACD ARREFMSGFT GSAGCAIVTL 70 80 90 100 110 120 EAAALATDGR YFNQAAKQLD GNWTLLKQGL QDVPTWQEWA ASQSAGGKTV AVDPSLLPGS 130 140 150 160 170 180 AAKKLNDQVR KAGGADLVPL DENIVDIAWG DSRPERPCQS VSVLPDELAG KPVTTKIEEL 190 200 210 220 230 240 RQELAKKNCP GFFVSMLDEV AWLFNLRGND IPYNPVFFSY ATITPETAIL YVDESKLDES 250 260 270 280 290 300 CRAHLRENNV QVKPYDSFFP DARQLHTEVK AKRQAGGDGV VVGNFLISNK ASWAMSRALG 310 320 330 340 350 360 GDGSVEEMRS PVGDAKAVKN ETEMNGMRAC HVRDGAALIE FFAWLEDQLA DKKIMIDEVQ 370 380 390 400 410 420 AADKLEELRS KHQHFVGLSF PTISSTGANA AIIHYGPEKG SCATIDPGRV YLCDSGAQYR 430 440 450 460 470 480 DGTTDTTRTL HFGKPSDAEK KAYTLVLKGL IGLDTAVFPK GTTGFALDCL ARQHLWKNGL 490 500 510 520 530 540 DYRHGTGHGV GSYLNVHEGP IGIGTRVQYT EVPLAPGNVL SNEPGYYEDG NFGIRIENIM 550 560 570 580 590 600 MVREVQTEHC FGDKSYLGFE HVTMVPYCQS LIERDMLTAD EKAWLNAYND EVLKNTKGFF 610 QGDDLTMAWL TRETRPIE

References

[1]

"Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum." Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J. , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C. PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ARSEF 23 / ATCC MYA-3075.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GL698714 Genomic DNA. Translation: EFZ01049.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_METAR

Accession

Primary (citable) accession number: E9EUE6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program