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E9ETL5 (DAPB_METAR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:MAA_03364
OrganismMetarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075) [Complete proteome]
Taxonomic identifier655844 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium

Protein attributes

Sequence length903 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 903903Probable dipeptidyl-aminopeptidase B
PRO_0000412149

Regions

Topological domain1 – 9494Cytoplasmic Potential
Transmembrane95 – 11521Helical; Signal-anchor for type II membrane protein; Potential
Topological domain116 – 903788Vacuolar Potential

Sites

Active site7601Charge relay system By similarity
Active site8371Charge relay system By similarity
Active site8701Charge relay system By similarity

Amino acid modifications

Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation5771N-linked (GlcNAc...) Potential
Glycosylation8191N-linked (GlcNAc...) Potential
Glycosylation8921N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
E9ETL5 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 4876152CA1B420DC

FASTA903101,090
        10         20         30         40         50         60 
MAPPFTDDPE SQRPSTSRLS QDSLSSVSTT SLVFDRIQEE MDRDPSASRS ARRDLLPATK 

        70         80         90        100        110        120 
DEGDFDENAS ETGAFLGPPG VPLQRQPMDR GFRRILIIIG AVFVGAWLAG LGIFVLSGSY 

       130        140        150        160        170        180 
KHESDSEHDP DANSRGSGKA VTMDQVFGGF WSARSHSISW IADPDGGDGL LLEVNTANGY 

       190        200        210        220        230        240 
LVVEDVRADK ESTDTNAGQT ADTQPAKPRV LMRDPYFMYH GEIKRPDWNE PSPDLKKVLL 

       250        260        270        280        290        300 
AVKREKNWRH SFQATYFILD VETAQVQPLV PDNVNAKVQL ANWSPTSDAI SFTMDNNIYI 

       310        320        330        340        350        360 
RRLNQANDVV QITKDGGPEY FYGIPDWVYE EEVFAGRSAT WWSDDGKYLA FLRTNETAVP 

       370        380        390        400        410        420 
EYAIEYYIQR PSGKKPAVGE EAYPEIRKIK YPKPGAHNPV VDVQYYDVSK GDVFSISAPD 

       430        440        450        460        470        480 
EFPDHDRIIS NVLWAGNKVL LKQSNRIGDF LKVILVDPSQ REAKIVNSIN IAEIDGGWFE 

       490        500        510        520        530        540 
ISHTMTYIPA DPSKGRQQDG YVDTVIHEGY EHIGYFTPID NPKPIMLTSG SWEVEDAPSA 

       550        560        570        580        590        600 
VDLNNNLVYF VATKESSIQR HVYSVKLDGT NLTPLTNTSS EGYYTVSFSS RSGFALLSYK 

       610        620        630        640        650        660 
GPKIPYQKVI STPSIPIQFS RTIEDNADLA DKAKKHELPI LKYGTLQLPN GISVNYLERR 

       670        680        690        700        710        720 
PPHFNPKKKY PILFQQYSGP KSQTVTKKFA VDFQSYVASS LGYLVVTIDP RGTGFLGRQH 

       730        740        750        760        770        780 
RVVVRSQLGV LEAQDHIAAA KHYSSLPYVD PSRLAIWGWS YGGFQTLKTL EVDAGDTFSY 

       790        800        810        820        830        840 
GMAVAPVTDW RFYDSIYTER YMRLPQDNTA GYDASAVRNA TALGMNKRFL IMHGSADDNV 

       850        860        870        880        890        900 
HFQNSLKLLD YLDLAGIENY DVHVFPDSDH SIAFHGANRM VYDKRASRLG VNSSLRIYSR 


AFI 

« Hide

References

[1]"Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J. expand/collapse author list , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ARSEF 23 / ATCC MYA-3075.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GL698714 Genomic DNA. Translation: EFZ00768.1.
RefSeqXP_007819553.1. XM_007821362.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19257650.

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMSSF53474. SSF53474. 1 hit.
ProtoNetSearch...

Entry information

Entry nameDAPB_METAR
AccessionPrimary (citable) accession number: E9ETL5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries