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E9ETL5

- DAPB_METAR

UniProt

E9ETL5 - DAPB_METAR

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, MAA_03364
Organism
Metarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei760 – 7601Charge relay system By similarity
Active sitei837 – 8371Charge relay system By similarity
Active sitei870 – 8701Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:MAA_03364
    OrganismiMetarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075)
    Taxonomic identifieri655844 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium
    ProteomesiUP000002498: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles By similarity.

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9494Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei95 – 11521Helical; Signal-anchor for type II membrane protein; Reviewed prediction
    Add
    BLAST
    Topological domaini116 – 903788Vacuolar Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 903903Probable dipeptidyl-aminopeptidase B
    PRO_0000412149Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi355 – 3551N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi577 – 5771N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi819 – 8191N-linked (GlcNAc...) Reviewed prediction
    Glycosylationi892 – 8921N-linked (GlcNAc...) Reviewed prediction

    Keywords - PTMi

    Glycoprotein

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E9ETL5-1 [UniParc]FASTAAdd to Basket

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    MAPPFTDDPE SQRPSTSRLS QDSLSSVSTT SLVFDRIQEE MDRDPSASRS    50
    ARRDLLPATK DEGDFDENAS ETGAFLGPPG VPLQRQPMDR GFRRILIIIG 100
    AVFVGAWLAG LGIFVLSGSY KHESDSEHDP DANSRGSGKA VTMDQVFGGF 150
    WSARSHSISW IADPDGGDGL LLEVNTANGY LVVEDVRADK ESTDTNAGQT 200
    ADTQPAKPRV LMRDPYFMYH GEIKRPDWNE PSPDLKKVLL AVKREKNWRH 250
    SFQATYFILD VETAQVQPLV PDNVNAKVQL ANWSPTSDAI SFTMDNNIYI 300
    RRLNQANDVV QITKDGGPEY FYGIPDWVYE EEVFAGRSAT WWSDDGKYLA 350
    FLRTNETAVP EYAIEYYIQR PSGKKPAVGE EAYPEIRKIK YPKPGAHNPV 400
    VDVQYYDVSK GDVFSISAPD EFPDHDRIIS NVLWAGNKVL LKQSNRIGDF 450
    LKVILVDPSQ REAKIVNSIN IAEIDGGWFE ISHTMTYIPA DPSKGRQQDG 500
    YVDTVIHEGY EHIGYFTPID NPKPIMLTSG SWEVEDAPSA VDLNNNLVYF 550
    VATKESSIQR HVYSVKLDGT NLTPLTNTSS EGYYTVSFSS RSGFALLSYK 600
    GPKIPYQKVI STPSIPIQFS RTIEDNADLA DKAKKHELPI LKYGTLQLPN 650
    GISVNYLERR PPHFNPKKKY PILFQQYSGP KSQTVTKKFA VDFQSYVASS 700
    LGYLVVTIDP RGTGFLGRQH RVVVRSQLGV LEAQDHIAAA KHYSSLPYVD 750
    PSRLAIWGWS YGGFQTLKTL EVDAGDTFSY GMAVAPVTDW RFYDSIYTER 800
    YMRLPQDNTA GYDASAVRNA TALGMNKRFL IMHGSADDNV HFQNSLKLLD 850
    YLDLAGIENY DVHVFPDSDH SIAFHGANRM VYDKRASRLG VNSSLRIYSR 900
    AFI 903
    Length:903
    Mass (Da):101,090
    Last modified:April 5, 2011 - v1
    Checksum:i4876152CA1B420DC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL698714 Genomic DNA. Translation: EFZ00768.1.
    RefSeqiXP_007819553.1. XM_007821362.1.

    Genome annotation databases

    GeneIDi19257650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL698714 Genomic DNA. Translation: EFZ00768.1 .
    RefSeqi XP_007819553.1. XM_007821362.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 19257650.

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
      Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J.
      , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
      PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ARSEF 23 / ATCC MYA-3075.

    Entry informationi

    Entry nameiDAPB_METAR
    AccessioniPrimary (citable) accession number: E9ETL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 5, 2011
    Last modified: July 9, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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