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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei760Charge relay systemBy similarity1
Active sitei837Charge relay systemBy similarity1
Active sitei870Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERimetar-dapb. DPP4N_Peptidase_S9.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:MAA_03364
OrganismiMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Taxonomic identifieri655844 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaeMetarhizium
Proteomesi
  • UP000002498 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 94CytoplasmicSequence analysisAdd BLAST94
Transmembranei95 – 115Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini116 – 915VacuolarSequence analysisAdd BLAST800

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121491 – 915Probable dipeptidyl-aminopeptidase BAdd BLAST915

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi355N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi577N-linked (GlcNAc...)PROSITE-ProRule annotation1
Glycosylationi819N-linked (GlcNAc...)PROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

E9ETL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPFTDDPE SQRPSTSRLS QDSLSSVSTT SLVFDRIQEE MDRDPSASRS
60 70 80 90 100
ARRDLLPATK DEGDFDENAS ETGAFLGPPG VPLQRQPMDR GFRRILIIIG
110 120 130 140 150
AVFVGAWLAG LGIFVLSGSY KHESDSEHDP DANSRGSGKA VTMDQVFGGF
160 170 180 190 200
WSARSHSISW IADPDGGDGL LLEVNTANGY LVVEDVRADK ESTDTNAGQT
210 220 230 240 250
ADTQPAKPRV LMRDPYFMYH GEIKRPDWNE PSPDLKKVLL AVKREKNWRH
260 270 280 290 300
SFQATYFILD VETAQVQPLV PDNVNAKVQL ANWSPTSDAI SFTMDNNIYI
310 320 330 340 350
RRLNQANDVV QITKDGGPEY FYGIPDWVYE EEVFAGRSAT WWSDDGKYLA
360 370 380 390 400
FLRTNETAVP EYAIEYYIQR PSGKKPAVGE EAYPEIRKIK YPKPGAHNPV
410 420 430 440 450
VDVQYYDVSK GDVFSISAPD EFPDHDRIIS NVLWAGNKVL LKQSNRIGDF
460 470 480 490 500
LKVILVDPSQ REAKIVNSIN IAEIDGGWFE ISHTMTYIPA DPSKGRQQDG
510 520 530 540 550
YVDTVIHEGY EHIGYFTPID NPKPIMLTSG SWEVEDAPSA VDLNNNLVYF
560 570 580 590 600
VATKESSIQR HVYSVKLDGT NLTPLTNTSS EGYYTVSFSS RSGFALLSYK
610 620 630 640 650
GPKIPYQKVI STPSIPIQFS RTIEDNADLA DKAKKHELPI LKYGTLQLPN
660 670 680 690 700
GISVNYLERR PPHFNPKKKY PILFQQYSGP KSQTVTKKFA VDFQSYVASS
710 720 730 740 750
LGYLVVTIDP RGTGFLGRQH RVVVRSQLGV LEAQDHIAAA KHYSSLPYVD
760 770 780 790 800
PSRLAIWGWS YGGFQTLKTL EVDAGDTFSY GMAVAPVTDW RFYDSIYTER
810 820 830 840 850
YMRLPQDNTA GYDASAVRNA TALGMNKRFL IMHGSADDNV HFQNSLKLLD
860 870 880 890 900
YLDLAGIENY DVHVFPDSDH SIAFHGANRM VYDRLNNWLV NAFNGEWLKI
910
ADPKPIDTKK RRHVS
Length:915
Mass (Da):102,613
Last modified:March 4, 2015 - v2
Checksum:i8F1FCAEF3680F64D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADNJ02000003 Genomic DNA. Translation: EFZ00768.2.
RefSeqiXP_007819553.2. XM_007821362.2.

Genome annotation databases

EnsemblFungiiEFZ00768; EFZ00768; MAA_03364.
GeneIDi19257650.
KEGGimaj:MAA_03364.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADNJ02000003 Genomic DNA. Translation: EFZ00768.2.
RefSeqiXP_007819553.2. XM_007821362.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimetar-dapb. DPP4N_Peptidase_S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFZ00768; EFZ00768; MAA_03364.
GeneIDi19257650.
KEGGimaj:MAA_03364.

Phylogenomic databases

KOiK01282.
OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPB_METRA
AccessioniPrimary (citable) accession number: E9ETL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 4, 2015
Last modified: September 7, 2016
This is version 26 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.