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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei183PROSITE-ProRule annotation1
Active sitei382PROSITE-ProRule annotation1
Active sitei444PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERimetaq-kex1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:MAA_02969
OrganismiMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Taxonomic identifieri655844 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaeMetarhizium
Proteomesi
  • UP000002498 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 516LumenalSequence analysisAdd BLAST488
Transmembranei517 – 537HelicalSequence analysisAdd BLAST21
Topological domaini538 – 616CytoplasmicSequence analysisAdd BLAST79

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000041192729 – 616Pheromone-processing carboxypeptidase KEX1Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi119N-linked (GlcNAc...)Sequence analysis1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi357N-linked (GlcNAc...)Sequence analysis1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Glycosylationi441N-linked (GlcNAc...)Sequence analysis1
Glycosylationi493N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9ESM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRFSWSLA TSWHALAILA LWPASTLAGD KSAADYYVRE LPGLPKNSPP
60 70 80 90 100
IKMHAGHIEV TPETNGNLFF WHFQNNHIAN RQRTVIWLNG GPGCSSEDGA
110 120 130 140 150
LMEVGPYRVT KDNALTLNNG TWNEFANLLF VDNPVGTGFS YVDTNSYIHG
160 170 180 190 200
LNAMATQFIT FLEKFFALFP EYQSDDLYIA GESYAGQHIP YIARAILDRN
210 220 230 240 250
KSKSRAETWN LGGLLIGNGW ISPQDQSSAY LKFSLERGLI EKGSDNAQQL
260 270 280 290 300
QQMQRICDKE MSINPGHVDY PECESILNKI LELTRVGSGD QECINMYDVR
310 320 330 340 350
LRDSAPSCGM NWPPDLKYVG PYLRQPQVIS ALNLDKQRNT GWQECNSMVN
360 370 380 390 400
ANFRNQNATA SISLLPDILK EVPILLFSGA EDLICNHVGT EELISNLAWN
410 420 430 440 450
EGKGFEVTPG NWAPRRQWTF EGEVAGFWQE ARNLTYVLFH NASHMVPFDY
460 470 480 490 500
PRRSRDMLDR FMKVDISSIG GEPSDSRIDG EKGPDTSVGG AKNNTQQHEE
510 520 530 540 550
ETKQKLKEAQ WLAYQRSGEV VLVIVIIAAS VWGYFVWRQR RKGTAYSALQ
560 570 580 590 600
SDEAAGQSRT GLAAFHNRQS DRDLEAAAFD ETTVDNIPLQ ESIGRGESKY
610
SIGDDSDEEE GETNKT
Length:616
Mass (Da):68,961
Last modified:April 5, 2011 - v1
Checksum:i7EC426936D200C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADNJ02000004 Genomic DNA. Translation: EFZ01740.1.
RefSeqiXP_007819158.1. XM_007820967.1.

Genome annotation databases

EnsemblFungiiEFZ01740; EFZ01740; MAA_02969.
GeneIDi19257255.
KEGGimaj:MAA_02969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADNJ02000004 Genomic DNA. Translation: EFZ01740.1.
RefSeqiXP_007819158.1. XM_007820967.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERimetaq-kex1. Carboxypeptidase_S10.
MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFZ01740; EFZ01740; MAA_02969.
GeneIDi19257255.
KEGGimaj:MAA_02969.

Phylogenomic databases

KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_METRA
AccessioniPrimary (citable) accession number: E9ESM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.