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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Metarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831PROSITE-ProRule annotation
Active sitei382 – 3821PROSITE-ProRule annotation
Active sitei444 – 4441PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.A67.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:MAA_02969
OrganismiMetarhizium robertsii (strain ARSEF 23 / ATCC MYA-3075) (Metarhizium anisopliae (strain ARSEF 23))
Taxonomic identifieri655844 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium
ProteomesiUP000002498: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 516488LumenalSequence AnalysisAdd
BLAST
Transmembranei517 – 53721HelicalSequence AnalysisAdd
BLAST
Topological domaini538 – 61679CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 616588Pheromone-processing carboxypeptidase KEX1PRO_0000411927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi357 – 3571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi441 – 4411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi493 – 4931N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9ESM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRFSWSLA TSWHALAILA LWPASTLAGD KSAADYYVRE LPGLPKNSPP
60 70 80 90 100
IKMHAGHIEV TPETNGNLFF WHFQNNHIAN RQRTVIWLNG GPGCSSEDGA
110 120 130 140 150
LMEVGPYRVT KDNALTLNNG TWNEFANLLF VDNPVGTGFS YVDTNSYIHG
160 170 180 190 200
LNAMATQFIT FLEKFFALFP EYQSDDLYIA GESYAGQHIP YIARAILDRN
210 220 230 240 250
KSKSRAETWN LGGLLIGNGW ISPQDQSSAY LKFSLERGLI EKGSDNAQQL
260 270 280 290 300
QQMQRICDKE MSINPGHVDY PECESILNKI LELTRVGSGD QECINMYDVR
310 320 330 340 350
LRDSAPSCGM NWPPDLKYVG PYLRQPQVIS ALNLDKQRNT GWQECNSMVN
360 370 380 390 400
ANFRNQNATA SISLLPDILK EVPILLFSGA EDLICNHVGT EELISNLAWN
410 420 430 440 450
EGKGFEVTPG NWAPRRQWTF EGEVAGFWQE ARNLTYVLFH NASHMVPFDY
460 470 480 490 500
PRRSRDMLDR FMKVDISSIG GEPSDSRIDG EKGPDTSVGG AKNNTQQHEE
510 520 530 540 550
ETKQKLKEAQ WLAYQRSGEV VLVIVIIAAS VWGYFVWRQR RKGTAYSALQ
560 570 580 590 600
SDEAAGQSRT GLAAFHNRQS DRDLEAAAFD ETTVDNIPLQ ESIGRGESKY
610
SIGDDSDEEE GETNKT
Length:616
Mass (Da):68,961
Last modified:April 5, 2011 - v1
Checksum:i7EC426936D200C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADNJ02000004 Genomic DNA. Translation: EFZ01740.1.
RefSeqiXP_007819158.1. XM_007820967.1.

Genome annotation databases

GeneIDi19257255.
KEGGimaj:MAA_02969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ADNJ02000004 Genomic DNA. Translation: EFZ01740.1.
RefSeqiXP_007819158.1. XM_007820967.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.A67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19257255.
KEGGimaj:MAA_02969.

Phylogenomic databases

KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
    Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J.
    , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
    PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ARSEF 23 / ATCC MYA-3075.
  2. "Trajectory and genomic determinants of fungal-pathogen speciation and host adaptation."
    Hu X., Xiao G., Zheng P., Shang Y., Su Y., Zhang X., Liu X., Zhan S., St Leger R.J., Wang C.
    Proc. Natl. Acad. Sci. U.S.A. 111:16796-16801(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: ARSEF 23 / ATCC MYA-3075.

Entry informationi

Entry nameiKEX1_METRA
AccessioniPrimary (citable) accession number: E9ESM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: March 4, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.