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E9ESM3

- KEX1_METAR

UniProt

E9ESM3 - KEX1_METAR

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene
KEX1, MAA_02969
Organism
Metarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831 By similarity
Active sitei382 – 3821 By similarity
Active sitei444 – 4441 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:MAA_02969
OrganismiMetarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075)
Taxonomic identifieri655844 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium
ProteomesiUP000002498: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 516488Lumenal Reviewed predictionAdd
BLAST
Transmembranei517 – 53721Helical; Reviewed predictionAdd
BLAST
Topological domaini538 – 61679Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed predictionAdd
BLAST
Chaini29 – 616588Pheromone-processing carboxypeptidase KEX1PRO_0000411927Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi119 – 1191N-linked (GlcNAc...) Reviewed prediction
Glycosylationi200 – 2001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi357 – 3571N-linked (GlcNAc...) Reviewed prediction
Glycosylationi433 – 4331N-linked (GlcNAc...) Reviewed prediction
Glycosylationi441 – 4411N-linked (GlcNAc...) Reviewed prediction
Glycosylationi493 – 4931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9ESM3-1 [UniParc]FASTAAdd to Basket

« Hide

MAPRFSWSLA TSWHALAILA LWPASTLAGD KSAADYYVRE LPGLPKNSPP    50
IKMHAGHIEV TPETNGNLFF WHFQNNHIAN RQRTVIWLNG GPGCSSEDGA 100
LMEVGPYRVT KDNALTLNNG TWNEFANLLF VDNPVGTGFS YVDTNSYIHG 150
LNAMATQFIT FLEKFFALFP EYQSDDLYIA GESYAGQHIP YIARAILDRN 200
KSKSRAETWN LGGLLIGNGW ISPQDQSSAY LKFSLERGLI EKGSDNAQQL 250
QQMQRICDKE MSINPGHVDY PECESILNKI LELTRVGSGD QECINMYDVR 300
LRDSAPSCGM NWPPDLKYVG PYLRQPQVIS ALNLDKQRNT GWQECNSMVN 350
ANFRNQNATA SISLLPDILK EVPILLFSGA EDLICNHVGT EELISNLAWN 400
EGKGFEVTPG NWAPRRQWTF EGEVAGFWQE ARNLTYVLFH NASHMVPFDY 450
PRRSRDMLDR FMKVDISSIG GEPSDSRIDG EKGPDTSVGG AKNNTQQHEE 500
ETKQKLKEAQ WLAYQRSGEV VLVIVIIAAS VWGYFVWRQR RKGTAYSALQ 550
SDEAAGQSRT GLAAFHNRQS DRDLEAAAFD ETTVDNIPLQ ESIGRGESKY 600
SIGDDSDEEE GETNKT 616
Length:616
Mass (Da):68,961
Last modified:April 5, 2011 - v1
Checksum:i7EC426936D200C65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL698713 Genomic DNA. Translation: EFZ01740.1.
RefSeqiXP_007819158.1. XM_007820967.1.

Genome annotation databases

GeneIDi19257255.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL698713 Genomic DNA. Translation: EFZ01740.1 .
RefSeqi XP_007819158.1. XM_007820967.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi S10.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 19257255.

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
    Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J.
    , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
    PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ARSEF 23 / ATCC MYA-3075.

Entry informationi

Entry nameiKEX1_METAR
AccessioniPrimary (citable) accession number: E9ESM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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