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E9ESM3 (KEX1_METAR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pheromone-processing carboxypeptidase KEX1

EC=3.4.16.6
Alternative name(s):
Carboxypeptidase D
Gene names
Name:KEX1
ORF Names:MAA_02969
OrganismMetarhizium anisopliae (strain ARSEF 23 / ATCC MYA-3075) [Complete proteome]
Taxonomic identifier655844 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium

Protein attributes

Sequence length616 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activity

Preferential release of a C-terminal arginine or lysine residue.

Subcellular location

Golgi apparatustrans-Golgi network membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the peptidase S10 family.

Ontologies

Keywords
   Biological processApoptosis
   Cellular componentGolgi apparatus
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionCarboxypeptidase
Hydrolase
Protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processapoptotic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionserine-type carboxypeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 616588Pheromone-processing carboxypeptidase KEX1
PRO_0000411927

Regions

Topological domain29 – 516488Lumenal Potential
Transmembrane517 – 53721Helical; Potential
Topological domain538 – 61679Cytoplasmic Potential

Sites

Active site1831 By similarity
Active site3821 By similarity
Active site4441 By similarity

Amino acid modifications

Glycosylation1191N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation3571N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation4411N-linked (GlcNAc...) Potential
Glycosylation4931N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
E9ESM3 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 7EC426936D200C65

FASTA61668,961
        10         20         30         40         50         60 
MAPRFSWSLA TSWHALAILA LWPASTLAGD KSAADYYVRE LPGLPKNSPP IKMHAGHIEV 

        70         80         90        100        110        120 
TPETNGNLFF WHFQNNHIAN RQRTVIWLNG GPGCSSEDGA LMEVGPYRVT KDNALTLNNG 

       130        140        150        160        170        180 
TWNEFANLLF VDNPVGTGFS YVDTNSYIHG LNAMATQFIT FLEKFFALFP EYQSDDLYIA 

       190        200        210        220        230        240 
GESYAGQHIP YIARAILDRN KSKSRAETWN LGGLLIGNGW ISPQDQSSAY LKFSLERGLI 

       250        260        270        280        290        300 
EKGSDNAQQL QQMQRICDKE MSINPGHVDY PECESILNKI LELTRVGSGD QECINMYDVR 

       310        320        330        340        350        360 
LRDSAPSCGM NWPPDLKYVG PYLRQPQVIS ALNLDKQRNT GWQECNSMVN ANFRNQNATA 

       370        380        390        400        410        420 
SISLLPDILK EVPILLFSGA EDLICNHVGT EELISNLAWN EGKGFEVTPG NWAPRRQWTF 

       430        440        450        460        470        480 
EGEVAGFWQE ARNLTYVLFH NASHMVPFDY PRRSRDMLDR FMKVDISSIG GEPSDSRIDG 

       490        500        510        520        530        540 
EKGPDTSVGG AKNNTQQHEE ETKQKLKEAQ WLAYQRSGEV VLVIVIIAAS VWGYFVWRQR 

       550        560        570        580        590        600 
RKGTAYSALQ SDEAAGQSRT GLAAFHNRQS DRDLEAAAFD ETTVDNIPLQ ESIGRGESKY 

       610 
SIGDDSDEEE GETNKT 

« Hide

References

[1]"Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J. expand/collapse author list , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ARSEF 23 / ATCC MYA-3075.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GL698713 Genomic DNA. Translation: EFZ01740.1.
RefSeqXP_007819158.1. XM_007820967.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS10.007.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID19257255.

Phylogenomic databases

OrthoDBEOG7TJ3SJ.

Family and domain databases

Gene3D3.40.50.1820. 1 hit.
InterProIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERPTHR11802. PTHR11802. 1 hit.
PfamPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSPR00724. CRBOXYPTASEC.
SUPFAMSSF53474. SSF53474. 1 hit.
PROSITEPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKEX1_METAR
AccessionPrimary (citable) accession number: E9ESM3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries