Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E9ED72 (DAPB_METAQ) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable dipeptidyl-aminopeptidase B

Short name=DPAP B
EC=3.4.14.5
Gene names
Name:DAPB
ORF Names:MAC_07820
OrganismMetarhizium acridum (strain CQMa 102) [Complete proteome]
Taxonomic identifier655827 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium

Protein attributes

Sequence length934 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activity

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Subcellular location

Vacuole membrane; Single-pass type II membrane protein By similarity. Note: Lysosome-like vacuoles By similarity.

Sequence similarities

Belongs to the peptidase S9B family.

Ontologies

Keywords
   Cellular componentMembrane
Vacuole
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   Molecular functionAminopeptidase
Hydrolase
Protease
Serine protease
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminopeptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

serine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 934934Probable dipeptidyl-aminopeptidase B
PRO_0000412148

Regions

Topological domain1 – 9393Cytoplasmic Potential
Transmembrane94 – 11421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain115 – 934820Vacuolar Potential

Sites

Active site7591Charge relay system By similarity
Active site8361Charge relay system By similarity
Active site8691Charge relay system By similarity

Amino acid modifications

Glycosylation3541N-linked (GlcNAc...) Potential
Glycosylation5761N-linked (GlcNAc...) Potential
Glycosylation8181N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
E9ED72 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 89ED7648E4BC6754

FASTA934104,515
        10         20         30         40         50         60 
MAPPFTDDPE SQRPSTSRLS QDSLSSVSTT SLVFDRIQEE MDRDPSSSRS ARRDLLSATK 

        70         80         90        100        110        120 
DEGDYEDASE TGAFLGQPGV PLQRQPMDRG FRRILIIIGA VFVGAWLAGL GVFVLSGSYR 

       130        140        150        160        170        180 
HESDSEHDPD AISRGSGKAV TMDQVFGGFW SAKSRSISWI ADPDGGDGLL LEVGTANGYL 

       190        200        210        220        230        240 
VVEDVRADKQ GTDTTSRQTA DTQPAKPRVL MKDPYFMYNG EIKRPEWNEP SPDLKKVLLA 

       250        260        270        280        290        300 
VNLEKNWRHS FQATYFILHV ETAQIQPLVP DNVNAKVQLA NWSPKSDAIS FTMDNNIYIR 

       310        320        330        340        350        360 
RLNQANDVVQ ITKDGGPEYF YGIPDWVYEE EVLAGRSATW WSDDGNYLAF LRTNETAVPE 

       370        380        390        400        410        420 
YAIEYYIQRP SGKKPAVGEE AYPEIRKIKY PKPGAHNPVV DVQYYDVSKG DVFSISAPDE 

       430        440        450        460        470        480 
FPDKDRIISN VLWAGNKVLL KQSNRVGDFL KVILVDPSER KAKIVNSINI AEIDGGWFEI 

       490        500        510        520        530        540 
SHTMTYIPAD PSKGRQQDGY VDTVIHEGYE HIGYFTPIDN PKPIMLTSGS WEVEDAPSAV 

       550        560        570        580        590        600 
DLDNNLVYFV ATKESSIQRH VYSVKLDGSN LTPLTNTSSE GYYAVSFSSR SGFALLSYQG 

       610        620        630        640        650        660 
PKIPYQKVIS TPSIPIEFSR TIEDNAGLAD KAKKHELPIL KYGTLQLPNG ISVNYLERRP 

       670        680        690        700        710        720 
PHFNPKKKYP ILFQQYSGPK SQTVTKKFAV NFQSYVASSL GYLVVTIDPR GTGFLGRQHR 

       730        740        750        760        770        780 
VVVRSQLGVL EAQDHIAAAK HYSSLPYVDP SRLAIWGWSY GGFQTLKTLE VDAGDTFSYG 

       790        800        810        820        830        840 
MAVAPVTDWR FYDSIYTERY MRLPQDNAAG YDASAVHNAT ALGMSKRFLI MHGSADDNVH 

       850        860        870        880        890        900 
FQNSLKLLDY LDLARIENYD VHVFPDSDHG IAFHGANRMV YDSKSEFSVL FSWILSPMLT 

       910        920        930 
LSGLNNWLVN AFNGEWLKIA DPKPIDTKKR RHVS 

« Hide

References

[1]"Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J. expand/collapse author list , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CQMa 102.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
GL698555 Genomic DNA. Translation: EFY86155.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

OrthoDBEOG72VHFG.

Family and domain databases

Gene3D2.140.10.30. 1 hit.
InterProIPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPB_METAQ
AccessionPrimary (citable) accession number: E9ED72
Entry history
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: April 16, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries