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E9ED72

- DAPB_METAQ

UniProt

E9ED72 - DAPB_METAQ

Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Metarhizium acridum (strain CQMa 102)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

    Catalytic activityi

    Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei759 – 7591Charge relay systemBy similarity
    Active sitei836 – 8361Charge relay systemBy similarity
    Active sitei869 – 8691Charge relay systemBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. serine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease, Serine protease

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
    Short name:
    DPAP B
    Gene namesi
    Name:DAPB
    ORF Names:MAC_07820
    OrganismiMetarhizium acridum (strain CQMa 102)
    Taxonomic identifieri655827 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium
    ProteomesiUP000002499: Unassembled WGS sequence

    Subcellular locationi

    Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
    Note: Lysosome-like vacuoles.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. vacuolar membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 934934Probable dipeptidyl-aminopeptidase BPRO_0000412148Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi818 – 8181N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini115 – 934820VacuolarSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei94 – 11421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase S9B family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG72VHFG.

    Family and domain databases

    Gene3Di2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view]
    PfamiPF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E9ED72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPPFTDDPE SQRPSTSRLS QDSLSSVSTT SLVFDRIQEE MDRDPSSSRS    50
    ARRDLLSATK DEGDYEDASE TGAFLGQPGV PLQRQPMDRG FRRILIIIGA 100
    VFVGAWLAGL GVFVLSGSYR HESDSEHDPD AISRGSGKAV TMDQVFGGFW 150
    SAKSRSISWI ADPDGGDGLL LEVGTANGYL VVEDVRADKQ GTDTTSRQTA 200
    DTQPAKPRVL MKDPYFMYNG EIKRPEWNEP SPDLKKVLLA VNLEKNWRHS 250
    FQATYFILHV ETAQIQPLVP DNVNAKVQLA NWSPKSDAIS FTMDNNIYIR 300
    RLNQANDVVQ ITKDGGPEYF YGIPDWVYEE EVLAGRSATW WSDDGNYLAF 350
    LRTNETAVPE YAIEYYIQRP SGKKPAVGEE AYPEIRKIKY PKPGAHNPVV 400
    DVQYYDVSKG DVFSISAPDE FPDKDRIISN VLWAGNKVLL KQSNRVGDFL 450
    KVILVDPSER KAKIVNSINI AEIDGGWFEI SHTMTYIPAD PSKGRQQDGY 500
    VDTVIHEGYE HIGYFTPIDN PKPIMLTSGS WEVEDAPSAV DLDNNLVYFV 550
    ATKESSIQRH VYSVKLDGSN LTPLTNTSSE GYYAVSFSSR SGFALLSYQG 600
    PKIPYQKVIS TPSIPIEFSR TIEDNAGLAD KAKKHELPIL KYGTLQLPNG 650
    ISVNYLERRP PHFNPKKKYP ILFQQYSGPK SQTVTKKFAV NFQSYVASSL 700
    GYLVVTIDPR GTGFLGRQHR VVVRSQLGVL EAQDHIAAAK HYSSLPYVDP 750
    SRLAIWGWSY GGFQTLKTLE VDAGDTFSYG MAVAPVTDWR FYDSIYTERY 800
    MRLPQDNAAG YDASAVHNAT ALGMSKRFLI MHGSADDNVH FQNSLKLLDY 850
    LDLARIENYD VHVFPDSDHG IAFHGANRMV YDSKSEFSVL FSWILSPMLT 900
    LSGLNNWLVN AFNGEWLKIA DPKPIDTKKR RHVS 934
    Length:934
    Mass (Da):104,515
    Last modified:April 5, 2011 - v1
    Checksum:i89ED7648E4BC6754
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL698555 Genomic DNA. Translation: EFY86155.1.
    RefSeqiXP_007814160.1. XM_007815969.1.

    Genome annotation databases

    GeneIDi19252131.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL698555 Genomic DNA. Translation: EFY86155.1 .
    RefSeqi XP_007814160.1. XM_007815969.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 19252131.

    Phylogenomic databases

    OrthoDBi EOG72VHFG.

    Family and domain databases

    Gene3Di 2.140.10.30. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001375. Peptidase_S9.
    IPR002469. Peptidase_S9B.
    [Graphical view ]
    Pfami PF00930. DPPIV_N. 1 hit.
    PF00326. Peptidase_S9. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
      Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J.
      , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
      PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CQMa 102.

    Entry informationi

    Entry nameiDAPB_METAQ
    AccessioniPrimary (citable) accession number: E9ED72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3