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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Metarhizium acridum (strain CQMa 102)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei759 – 7591Charge relay systemBy similarity
Active sitei836 – 8361Charge relay systemBy similarity
Active sitei869 – 8691Charge relay systemBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:MAC_07820
OrganismiMetarhizium acridum (strain CQMa 102)
Taxonomic identifieri655827 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesClavicipitaceaemitosporic ClavicipitaceaeMetarhizium
ProteomesiUP000002499 Componenti: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane By similarity; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9393CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei94 – 11421Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini115 – 934820VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 934934Probable dipeptidyl-aminopeptidase BPRO_0000412148Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi354 – 3541N-linked (GlcNAc...)Sequence Analysis
Glycosylationi576 – 5761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi818 – 8181N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiE9ED72.
KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

E9ED72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPFTDDPE SQRPSTSRLS QDSLSSVSTT SLVFDRIQEE MDRDPSSSRS
60 70 80 90 100
ARRDLLSATK DEGDYEDASE TGAFLGQPGV PLQRQPMDRG FRRILIIIGA
110 120 130 140 150
VFVGAWLAGL GVFVLSGSYR HESDSEHDPD AISRGSGKAV TMDQVFGGFW
160 170 180 190 200
SAKSRSISWI ADPDGGDGLL LEVGTANGYL VVEDVRADKQ GTDTTSRQTA
210 220 230 240 250
DTQPAKPRVL MKDPYFMYNG EIKRPEWNEP SPDLKKVLLA VNLEKNWRHS
260 270 280 290 300
FQATYFILHV ETAQIQPLVP DNVNAKVQLA NWSPKSDAIS FTMDNNIYIR
310 320 330 340 350
RLNQANDVVQ ITKDGGPEYF YGIPDWVYEE EVLAGRSATW WSDDGNYLAF
360 370 380 390 400
LRTNETAVPE YAIEYYIQRP SGKKPAVGEE AYPEIRKIKY PKPGAHNPVV
410 420 430 440 450
DVQYYDVSKG DVFSISAPDE FPDKDRIISN VLWAGNKVLL KQSNRVGDFL
460 470 480 490 500
KVILVDPSER KAKIVNSINI AEIDGGWFEI SHTMTYIPAD PSKGRQQDGY
510 520 530 540 550
VDTVIHEGYE HIGYFTPIDN PKPIMLTSGS WEVEDAPSAV DLDNNLVYFV
560 570 580 590 600
ATKESSIQRH VYSVKLDGSN LTPLTNTSSE GYYAVSFSSR SGFALLSYQG
610 620 630 640 650
PKIPYQKVIS TPSIPIEFSR TIEDNAGLAD KAKKHELPIL KYGTLQLPNG
660 670 680 690 700
ISVNYLERRP PHFNPKKKYP ILFQQYSGPK SQTVTKKFAV NFQSYVASSL
710 720 730 740 750
GYLVVTIDPR GTGFLGRQHR VVVRSQLGVL EAQDHIAAAK HYSSLPYVDP
760 770 780 790 800
SRLAIWGWSY GGFQTLKTLE VDAGDTFSYG MAVAPVTDWR FYDSIYTERY
810 820 830 840 850
MRLPQDNAAG YDASAVHNAT ALGMSKRFLI MHGSADDNVH FQNSLKLLDY
860 870 880 890 900
LDLARIENYD VHVFPDSDHG IAFHGANRMV YDSKSEFSVL FSWILSPMLT
910 920 930
LSGLNNWLVN AFNGEWLKIA DPKPIDTKKR RHVS
Length:934
Mass (Da):104,515
Last modified:April 5, 2011 - v1
Checksum:i89ED7648E4BC6754
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL698555 Genomic DNA. Translation: EFY86155.1.
RefSeqiXP_007814160.1. XM_007815969.1.

Genome annotation databases

GeneIDi19252131.
KEGGimaw:MAC_07820.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL698555 Genomic DNA. Translation: EFY86155.1.
RefSeqiXP_007814160.1. XM_007815969.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi19252131.
KEGGimaw:MAC_07820.

Phylogenomic databases

InParanoidiE9ED72.
KOiK01282.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum."
    Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J.
    , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C.
    PLoS Genet. 7:E1001264-E1001264(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CQMa 102.

Entry informationi

Entry nameiDAPB_METAQ
AccessioniPrimary (citable) accession number: E9ED72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: January 7, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.