E9E2J4 (AMPP2_METAQ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase MAC_04092
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

ORF Names:

MAC_04092

Organism

Metarhizium acridum (strain CQMa 102) [Complete proteome]

Taxonomic identifier

655827 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Hypocreomycetidae › Hypocreales › Clavicipitaceae › mitosporic Clavicipitaceae › Metarhizium › Metarhizium acridum

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: InterPro metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 509	509	Probable Xaa-Pro aminopeptidase MAC_04092		PRO_0000411837
Sites
	Metal binding	273	1	Manganese 2 By similarity
	Metal binding	284	1	Manganese 1 By similarity
	Metal binding	284	1	Manganese 2 By similarity
	Metal binding	437	1	Manganese 1 By similarity
	Metal binding	478	1	Manganese 1 By similarity
	Metal binding	478	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E9E2J4 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: CC7342C4E68AD841	FASTA	509	56,347
	10 20 30 40 50 60 MDYDLVMEDE FDALCLDVRR DHDSASKTKY PAKLHARKVV KELGVDDGLI YLPGQPDISL 70 80 90 100 110 120 ENSDQPRLFR QRRYFFYITG ADFEDCAATY EVKHDKLTLW VPYVEPRQVL WFGSKPSAAE 130 140 150 160 170 180 CKRRYDVDEV RYTTQLSSFL RRFAAQPEPP VVYILHPDQA PDLGHGSQSQ LRLDSSLLLP 190 200 210 220 230 240 AMDRARVVKS DYEVAMVRRA NDISSAAHRR VAERILRLTN EREIEAIIQA VCIANGSRSQ 250 260 270 280 290 300 AYPIIAGSGA NGATLHYGAN NAPLGGKQCV VIDAGCEWNC YASDITRTLP LSGSWTPKAA 310 320 330 340 350 360 AIHAIVQRMQ QECIAKVGPG TAWRDIHLHA ASLGMEGLLG LGILKGRRED VARAGTVAAF 370 380 390 400 410 420 FPHGLGHHVG LEVHDVSGTL ALSAAEGHGT QLDFGKRAMV TPSMLADMTR SASSPDAAGV 430 440 450 460 470 480 QERKTQLLLP NMIVTVEPGI YFCREYLEGY FRSDPAHADF IDWDLLEEYY DVGGVRIEDC 490 500 ILVTEDGYEN LTVAPKGDEL LDVINKGEK

References

[1]

"Genome sequencing and comparative transcriptomics of the model entomopathogenic fungi Metarhizium anisopliae and M. acridum." Gao Q., Jin K., Ying S.-H., Zhang Y., Xiao G., Shang Y., Duan Z., Hu X., Xie X.-Q., Zhou G., Peng G., Luo Z., Huang W., Wang B., Fang W., Wang S., Zhong Y., Ma L.-J. , St Leger R.J., Zhao G.-P., Pei Y., Feng M.-G., Xia Y., Wang C. PLoS Genet. 7:E1001264-E1001264(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CQMa 102.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GL698495 Genomic DNA. Translation: EFY89883.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.230.10. 2 hits.
InterPro	IPR007865. Aminopep_P_N. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF05195. AMP_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SMART	SM01011. AMP_N. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP2_METAQ

Accession

Primary (citable) accession number: E9E2J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program