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E9D269

- DPEP1_COCPS

UniProt

E9D269 - DPEP1_COCPS

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Protein

Putative dipeptidase CPSG_03667

Gene

CPSG_03667

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zinc.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi67 – 671Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi69 – 691Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi178 – 1781Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi178 – 1781Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei205 – 2051SubstratePROSITE-ProRule annotation
Metal bindingi250 – 2501Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi271 – 2711Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei282 – 2821SubstratePROSITE-ProRule annotation
Binding sitei342 – 3421SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase CPSG_03667 (EC:3.4.13.19)
Gene namesi
ORF Names:CPSG_03667
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000002497: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 444410Putative dipeptidase CPSG_03667PRO_0000411214Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi118 ↔ 207PROSITE-ProRule annotation
Glycosylationi413 – 4131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE9D269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9D269-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQRTEHNGS WLRNAGSLLS VLACVAVLAS PASATPASAA AAATPRTDDY
60 70 80 90 100
LKRAERILKF TPLIDGHNDL PNFIRKTTKN QIYEGKIPFE DELPGHTDLK
110 120 130 140 150
RLRKGRVGGQ FWSVYTPCPD PPVPIDDPTW SVRDTLEQID VTKRLIEKYS
160 170 180 190 200
RDLQFCGDAR CARRAFRRGK IASFLGIEGG HQIGNSLGDL RRVYELGVRY
210 220 230 240 250
ITVTHNCDNA FATAQSTVAD GLPDTGLMKP FGIEFVKEMN RLGMLVDLSH
260 270 280 290 300
VSANTMRDTL KVARAPVIFS HSSAYAVSNH LRNVPDDVLK EVAKNNGVVM
310 320 330 340 350
VTFVSRFVNV ENPDAADINT VVDHIFHIAK VAGWDHVGIG GDYDGTVYLP
360 370 380 390 400
KGLEDVSKYP HLIARVLERG ATTQQVRKLV GENILRVWTE VERIAKRLQK
410 420 430 440
TELPNEAYWE GRNWTRPAKR DLNADFEGRS VPLFTSASNG DFCD
Length:444
Mass (Da):49,382
Last modified:April 5, 2011 - v1
Checksum:iD89082950FCE9BB2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL636490 Genomic DNA. Translation: EFW19283.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL636490 Genomic DNA. Translation: EFW19283.1 .

3D structure databases

ProteinModelPortali E9D269.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7XM371.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RMSCC 757 / Silveira.

Entry informationi

Entry nameiDPEP1_COCPS
AccessioniPrimary (citable) accession number: E9D269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: October 1, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3