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Protein

Putative dipeptidase CPSG_03667

Gene

CPSG_03667

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi69Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi178Zinc 1; catalyticPROSITE-ProRule annotation1
Metal bindingi178Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei205SubstratePROSITE-ProRule annotation1
Metal bindingi250Zinc 2; catalyticPROSITE-ProRule annotation1
Metal bindingi271Zinc 2; catalyticPROSITE-ProRule annotation1
Binding sitei282SubstratePROSITE-ProRule annotation1
Binding sitei342SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase CPSG_03667 (EC:3.4.13.19)
Gene namesi
ORF Names:CPSG_03667
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000002497 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000041121435 – 444Putative dipeptidase CPSG_03667Add BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi118 ↔ 207PROSITE-ProRule annotation
Glycosylationi413N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE9D269.
SMRiE9D269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

OrthoDBiEOG092C2VQR.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9D269-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQRTEHNGS WLRNAGSLLS VLACVAVLAS PASATPASAA AAATPRTDDY
60 70 80 90 100
LKRAERILKF TPLIDGHNDL PNFIRKTTKN QIYEGKIPFE DELPGHTDLK
110 120 130 140 150
RLRKGRVGGQ FWSVYTPCPD PPVPIDDPTW SVRDTLEQID VTKRLIEKYS
160 170 180 190 200
RDLQFCGDAR CARRAFRRGK IASFLGIEGG HQIGNSLGDL RRVYELGVRY
210 220 230 240 250
ITVTHNCDNA FATAQSTVAD GLPDTGLMKP FGIEFVKEMN RLGMLVDLSH
260 270 280 290 300
VSANTMRDTL KVARAPVIFS HSSAYAVSNH LRNVPDDVLK EVAKNNGVVM
310 320 330 340 350
VTFVSRFVNV ENPDAADINT VVDHIFHIAK VAGWDHVGIG GDYDGTVYLP
360 370 380 390 400
KGLEDVSKYP HLIARVLERG ATTQQVRKLV GENILRVWTE VERIAKRLQK
410 420 430 440
TELPNEAYWE GRNWTRPAKR DLNADFEGRS VPLFTSASNG DFCD
Length:444
Mass (Da):49,382
Last modified:April 5, 2011 - v1
Checksum:iD89082950FCE9BB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636490 Genomic DNA. Translation: EFW19283.1.

Genome annotation databases

EnsemblFungiiEFW19283; EFW19283; CPSG_03667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636490 Genomic DNA. Translation: EFW19283.1.

3D structure databases

ProteinModelPortaliE9D269.
SMRiE9D269.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFW19283; EFW19283; CPSG_03667.

Phylogenomic databases

OrthoDBiEOG092C2VQR.

Family and domain databases

CDDicd01301. rDP_like. 1 hit.
InterProiIPR000180. Dipep_AS.
IPR032466. Metal_Hydrolase.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 1 hit.
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPEP1_COCPS
AccessioniPrimary (citable) accession number: E9D269
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.