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E9CV02

- DPEP2_COCPS

UniProt

E9CV02 - DPEP2_COCPS

Protein

Putative dipeptidase CPSG_01350

Gene

CPSG_01350

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Hydrolyzes a wide range of dipeptides.By similarity

    Catalytic activityi

    Hydrolysis of dipeptides.PROSITE-ProRule annotation

    Cofactori

    Zinc.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi90 – 901Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi92 – 921Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi203 – 2031Zinc 1; catalyticPROSITE-ProRule annotation
    Metal bindingi203 – 2031Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei230 – 2301SubstratePROSITE-ProRule annotation
    Metal bindingi274 – 2741Zinc 2; catalyticPROSITE-ProRule annotation
    Metal bindingi295 – 2951Zinc 2; catalyticPROSITE-ProRule annotation
    Binding sitei306 – 3061SubstratePROSITE-ProRule annotation
    Binding sitei366 – 3661SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. dipeptidase activity Source: UniProtKB-KW
    2. dipeptidyl-peptidase activity Source: InterPro
    3. metal ion binding Source: UniProtKB-KW
    4. metalloexopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Dipeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative dipeptidase CPSG_01350 (EC:3.4.13.19)
    Gene namesi
    ORF Names:CPSG_01350
    OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
    Taxonomic identifieri443226 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000002497: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 461461Putative dipeptidase CPSG_01350PRO_0000411217Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi142 ↔ 232PROSITE-ProRule annotation
    Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliE9CV02.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5218HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M19 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7XM371.

    Family and domain databases

    InterProiIPR000180. Dipep_AS.
    IPR008257. Renal_dipep_fam.
    [Graphical view]
    PANTHERiPTHR10443. PTHR10443. 1 hit.
    PfamiPF01244. Peptidase_M19. 1 hit.
    [Graphical view]
    PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E9CV02-1 [UniParc]FASTAAdd to Basket

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    MSARDNEKGS ARSQPSHAAA SEIENVPRPS RQQSWTGTMI KVFIICACAG    50
    IVSKYIIPLD SIFKSVHIDP HDYATRANRI LSTTPLIDGH NDLPYLIRLE 100
    TKNKIYDHEK LPFRTGLLSH TDQIKIQEGK LGGQFWSVFV ECATDPNAEI 150
    DDPTWAVRDT LEQIDVTKRL VQEYPDLLEY CESASCAKAA FKRGKVGSFL 200
    GIEGGHQIGN SLASLRQVYD LGVRYITVTH NCDNAFATAA STVAVGKPDL 250
    GLTDFGREFV KEMNRLGMLV DLSHVSHQTM RDILSVTKAP VMFSHSSSYA 300
    LSKHLRNVPD DVLNGVTKNG GVVMVTFVPS FLKVDDPASA TIHDAVDHIL 350
    HVAKVAGWDH VGIGSDFDGT ADVPEGLENV SKYPRLIELL LERGVTDEQA 400
    RKLIGENILR VWSNVEEIAE NIRALGEKPN EETWSGRKWT AAIDIPMPFM 450
    FKDSADKRKE L 461
    Length:461
    Mass (Da):51,063
    Last modified:April 5, 2011 - v1
    Checksum:i1BE71D05BCD42F28
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL636487 Genomic DNA. Translation: EFW21193.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL636487 Genomic DNA. Translation: EFW21193.1 .

    3D structure databases

    ProteinModelPortali E9CV02.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7XM371.

    Family and domain databases

    InterProi IPR000180. Dipep_AS.
    IPR008257. Renal_dipep_fam.
    [Graphical view ]
    PANTHERi PTHR10443. PTHR10443. 1 hit.
    Pfami PF01244. Peptidase_M19. 1 hit.
    [Graphical view ]
    PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
    PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RMSCC 757 / Silveira.

    Entry informationi

    Entry nameiDPEP2_COCPS
    AccessioniPrimary (citable) accession number: E9CV02
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3