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E9CV02

- DPEP2_COCPS

UniProt

E9CV02 - DPEP2_COCPS

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Protein

Putative dipeptidase CPSG_01350

Gene

CPSG_01350

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Hydrolyzes a wide range of dipeptides.By similarity

Catalytic activityi

Hydrolysis of dipeptides.PROSITE-ProRule annotation

Cofactori

Zn2+PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi90 – 901Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi92 – 921Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi203 – 2031Zinc 1; catalyticPROSITE-ProRule annotation
Metal bindingi203 – 2031Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei230 – 2301SubstratePROSITE-ProRule annotation
Metal bindingi274 – 2741Zinc 2; catalyticPROSITE-ProRule annotation
Metal bindingi295 – 2951Zinc 2; catalyticPROSITE-ProRule annotation
Binding sitei306 – 3061SubstratePROSITE-ProRule annotation
Binding sitei366 – 3661SubstratePROSITE-ProRule annotation

GO - Molecular functioni

  1. dipeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: InterPro
  3. metal ion binding Source: UniProtKB-KW
  4. metalloexopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Dipeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM19.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dipeptidase CPSG_01350 (EC:3.4.13.19)
Gene namesi
ORF Names:CPSG_01350
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000002497: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5218HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Putative dipeptidase CPSG_01350PRO_0000411217Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi142 ↔ 232PROSITE-ProRule annotation
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE9CV02.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M19 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7XM371.

Family and domain databases

InterProiIPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view]
PANTHERiPTHR10443. PTHR10443. 1 hit.
PfamiPF01244. Peptidase_M19. 1 hit.
[Graphical view]
PROSITEiPS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9CV02-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSARDNEKGS ARSQPSHAAA SEIENVPRPS RQQSWTGTMI KVFIICACAG
60 70 80 90 100
IVSKYIIPLD SIFKSVHIDP HDYATRANRI LSTTPLIDGH NDLPYLIRLE
110 120 130 140 150
TKNKIYDHEK LPFRTGLLSH TDQIKIQEGK LGGQFWSVFV ECATDPNAEI
160 170 180 190 200
DDPTWAVRDT LEQIDVTKRL VQEYPDLLEY CESASCAKAA FKRGKVGSFL
210 220 230 240 250
GIEGGHQIGN SLASLRQVYD LGVRYITVTH NCDNAFATAA STVAVGKPDL
260 270 280 290 300
GLTDFGREFV KEMNRLGMLV DLSHVSHQTM RDILSVTKAP VMFSHSSSYA
310 320 330 340 350
LSKHLRNVPD DVLNGVTKNG GVVMVTFVPS FLKVDDPASA TIHDAVDHIL
360 370 380 390 400
HVAKVAGWDH VGIGSDFDGT ADVPEGLENV SKYPRLIELL LERGVTDEQA
410 420 430 440 450
RKLIGENILR VWSNVEEIAE NIRALGEKPN EETWSGRKWT AAIDIPMPFM
460
FKDSADKRKE L
Length:461
Mass (Da):51,063
Last modified:April 5, 2011 - v1
Checksum:i1BE71D05BCD42F28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636487 Genomic DNA. Translation: EFW21193.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636487 Genomic DNA. Translation: EFW21193.1 .

3D structure databases

ProteinModelPortali E9CV02.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi M19.A01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7XM371.

Family and domain databases

InterProi IPR000180. Dipep_AS.
IPR008257. Renal_dipep_fam.
[Graphical view ]
PANTHERi PTHR10443. PTHR10443. 1 hit.
Pfami PF01244. Peptidase_M19. 1 hit.
[Graphical view ]
PROSITEi PS00869. RENAL_DIPEPTIDASE_1. 1 hit.
PS51365. RENAL_DIPEPTIDASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RMSCC 757 / Silveira.

Entry informationi

Entry nameiDPEP2_COCPS
AccessioniPrimary (citable) accession number: E9CV02
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3