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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay systemBy similarity
Active sitei831 – 8311Charge relay systemBy similarity
Active sitei864 – 8641Charge relay systemBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:CPSG_00188
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000002497 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini112 – 917806VacuolarSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 917917Probable dipeptidyl-aminopeptidase BPRO_0000412143Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi465 – 4651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE9CUF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

E9CUF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEKRINDE EMQPLAERDD KSRDSIDSTS TASISLALLG GANGSAHGSR
60 70 80 90 100
AARTRKSENQ EKYHDDEEEG DLEEGFVPPA GGWSAPRKVS VIFTLIVTLC
110 120 130 140 150
IAGWLVAFFV LLGRHKDSSK DAAVSQGESN IIPGIYSGGR GGKKLDLDGV
160 170 180 190 200
LFGNWSPKSH DISWFPGPNG ADGLLLEQGG DRNKAYLRVE DIRSRNPGNK
210 220 230 240 250
ADDTIVLMRE SSFMVGKRLV RPSKVWPSPD LKTVLVMSDQ RKNWRHSYTG
260 270 280 290 300
NYWIFDVETQ TGEPLDPESL DGGIQLASWS PNSDAIVFTR KNNMFIRRLP
310 320 330 340 350
SKNVKQITTD GGTNLFYGIP DWVYEEEVFS DSSATWWDGD GKFVAFLRTN
360 370 380 390 400
ESRVPEYPVQ YFIPNTNKPS RPSEENYPDI RKIKYPKAGA PNPVVNIQFF
410 420 430 440 450
DVEKEEVFSV DVKDDLPDDD RLVIGVTWAS NGNVLVRETN RESDRLSVVL
460 470 480 490 500
IDAAKRAGKV VRSRNFSSLD GGWVEPSQTT HFVPADPKNG RPHDGYIETI
510 520 530 540 550
PHDGFEHLAY FTPMDNSEPT VLTSGDWEVV DAPSAVDLKR GLVYFVAAKE
560 570 580 590 600
NPTERHIYTV KLDGSDLQPI VDTKSAGYYS ISLSAGAGYA LLKYEGPDIP
610 620 630 640 650
WQKVISTPAN EEKYEESIEK NPGLADMARK YALPSLHYQT ITISGYELQV
660 670 680 690 700
VERRPANFNP DKKYPVLFHL YGGPGSQTVT KKFKVDFQSY VASNLGYIVV
710 720 730 740 750
TVDGRGTGFI GRKARCAVRG NLGHYEAIDQ IETAKAWGKR SYVDAGRMAI
760 770 780 790 800
WGWSYGGFMT LKTLEQDAGQ TFQYGMAVAP VTDWRFYDSI YTERYMHTPQ
810 820 830 840 850
NNPEGYDRSA ISNVTALDQA VRFMIVHGSG DDNVHIQNTL TLLDKLDLGS
860 870 880 890 900
VKNFDVHVYP DSDHSIYFHN ANKMVYQRLS DWLVNAFNGE WVKTRDPIPH
910
KSLARRALGL INILRNG
Length:917
Mass (Da):102,500
Last modified:April 5, 2011 - v1
Checksum:i3986DB9EBD68189D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636486 Genomic DNA. Translation: EFW22289.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636486 Genomic DNA. Translation: EFW22289.1.

3D structure databases

ProteinModelPortaliE9CUF4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RMSCC 757 / Silveira.

Entry informationi

Entry nameiDAPB_COCPS
AccessioniPrimary (citable) accession number: E9CUF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: May 27, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.