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E9CUF4

- DAPB_COCPS

UniProt

E9CUF4 - DAPB_COCPS

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Protein
Probable dipeptidyl-aminopeptidase B
Gene
DAPB, CPSG_00188
Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei754 – 7541Charge relay system By similarity
Active sitei831 – 8311Charge relay system By similarity
Active sitei864 – 8641Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:CPSG_00188
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000002497: Unassembled WGS sequence

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9090Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei91 – 11121Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini112 – 917806Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 917917Probable dipeptidyl-aminopeptidase B
PRO_0000412143Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi350 – 3501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi465 – 4651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi813 – 8131N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE9CUF4.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

E9CUF4-1 [UniParc]FASTAAdd to Basket

« Hide

MGVEKRINDE EMQPLAERDD KSRDSIDSTS TASISLALLG GANGSAHGSR    50
AARTRKSENQ EKYHDDEEEG DLEEGFVPPA GGWSAPRKVS VIFTLIVTLC 100
IAGWLVAFFV LLGRHKDSSK DAAVSQGESN IIPGIYSGGR GGKKLDLDGV 150
LFGNWSPKSH DISWFPGPNG ADGLLLEQGG DRNKAYLRVE DIRSRNPGNK 200
ADDTIVLMRE SSFMVGKRLV RPSKVWPSPD LKTVLVMSDQ RKNWRHSYTG 250
NYWIFDVETQ TGEPLDPESL DGGIQLASWS PNSDAIVFTR KNNMFIRRLP 300
SKNVKQITTD GGTNLFYGIP DWVYEEEVFS DSSATWWDGD GKFVAFLRTN 350
ESRVPEYPVQ YFIPNTNKPS RPSEENYPDI RKIKYPKAGA PNPVVNIQFF 400
DVEKEEVFSV DVKDDLPDDD RLVIGVTWAS NGNVLVRETN RESDRLSVVL 450
IDAAKRAGKV VRSRNFSSLD GGWVEPSQTT HFVPADPKNG RPHDGYIETI 500
PHDGFEHLAY FTPMDNSEPT VLTSGDWEVV DAPSAVDLKR GLVYFVAAKE 550
NPTERHIYTV KLDGSDLQPI VDTKSAGYYS ISLSAGAGYA LLKYEGPDIP 600
WQKVISTPAN EEKYEESIEK NPGLADMARK YALPSLHYQT ITISGYELQV 650
VERRPANFNP DKKYPVLFHL YGGPGSQTVT KKFKVDFQSY VASNLGYIVV 700
TVDGRGTGFI GRKARCAVRG NLGHYEAIDQ IETAKAWGKR SYVDAGRMAI 750
WGWSYGGFMT LKTLEQDAGQ TFQYGMAVAP VTDWRFYDSI YTERYMHTPQ 800
NNPEGYDRSA ISNVTALDQA VRFMIVHGSG DDNVHIQNTL TLLDKLDLGS 850
VKNFDVHVYP DSDHSIYFHN ANKMVYQRLS DWLVNAFNGE WVKTRDPIPH 900
KSLARRALGL INILRNG 917
Length:917
Mass (Da):102,500
Last modified:April 5, 2011 - v1
Checksum:i3986DB9EBD68189D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL636486 Genomic DNA. Translation: EFW22289.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL636486 Genomic DNA. Translation: EFW22289.1 .

3D structure databases

ProteinModelPortali E9CUF4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RMSCC 757 / Silveira.

Entry informationi

Entry nameiDAPB_COCPS
AccessioniPrimary (citable) accession number: E9CUF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi