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Protein

Probable dipeptidyl-aminopeptidase B

Gene

DAPB

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.By similarity

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei754Charge relay systemBy similarity1
Active sitei831Charge relay systemBy similarity1
Active sitei864Charge relay systemBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

ESTHERicocp7-dapb. DPP4N_Peptidase_S9.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:DAPB
ORF Names:CPSG_00188
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesOnygenales incertae sedisCoccidioides
Proteomesi
  • UP000002497 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 90CytoplasmicSequence analysisAdd BLAST90
Transmembranei91 – 111Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini112 – 917VacuolarSequence analysisAdd BLAST806

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004121431 – 917Probable dipeptidyl-aminopeptidase BAdd BLAST917

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi350N-linked (GlcNAc...)Sequence analysis1
Glycosylationi465N-linked (GlcNAc...)Sequence analysis1
Glycosylationi813N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliE9CUF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S9B family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

E9CUF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVEKRINDE EMQPLAERDD KSRDSIDSTS TASISLALLG GANGSAHGSR
60 70 80 90 100
AARTRKSENQ EKYHDDEEEG DLEEGFVPPA GGWSAPRKVS VIFTLIVTLC
110 120 130 140 150
IAGWLVAFFV LLGRHKDSSK DAAVSQGESN IIPGIYSGGR GGKKLDLDGV
160 170 180 190 200
LFGNWSPKSH DISWFPGPNG ADGLLLEQGG DRNKAYLRVE DIRSRNPGNK
210 220 230 240 250
ADDTIVLMRE SSFMVGKRLV RPSKVWPSPD LKTVLVMSDQ RKNWRHSYTG
260 270 280 290 300
NYWIFDVETQ TGEPLDPESL DGGIQLASWS PNSDAIVFTR KNNMFIRRLP
310 320 330 340 350
SKNVKQITTD GGTNLFYGIP DWVYEEEVFS DSSATWWDGD GKFVAFLRTN
360 370 380 390 400
ESRVPEYPVQ YFIPNTNKPS RPSEENYPDI RKIKYPKAGA PNPVVNIQFF
410 420 430 440 450
DVEKEEVFSV DVKDDLPDDD RLVIGVTWAS NGNVLVRETN RESDRLSVVL
460 470 480 490 500
IDAAKRAGKV VRSRNFSSLD GGWVEPSQTT HFVPADPKNG RPHDGYIETI
510 520 530 540 550
PHDGFEHLAY FTPMDNSEPT VLTSGDWEVV DAPSAVDLKR GLVYFVAAKE
560 570 580 590 600
NPTERHIYTV KLDGSDLQPI VDTKSAGYYS ISLSAGAGYA LLKYEGPDIP
610 620 630 640 650
WQKVISTPAN EEKYEESIEK NPGLADMARK YALPSLHYQT ITISGYELQV
660 670 680 690 700
VERRPANFNP DKKYPVLFHL YGGPGSQTVT KKFKVDFQSY VASNLGYIVV
710 720 730 740 750
TVDGRGTGFI GRKARCAVRG NLGHYEAIDQ IETAKAWGKR SYVDAGRMAI
760 770 780 790 800
WGWSYGGFMT LKTLEQDAGQ TFQYGMAVAP VTDWRFYDSI YTERYMHTPQ
810 820 830 840 850
NNPEGYDRSA ISNVTALDQA VRFMIVHGSG DDNVHIQNTL TLLDKLDLGS
860 870 880 890 900
VKNFDVHVYP DSDHSIYFHN ANKMVYQRLS DWLVNAFNGE WVKTRDPIPH
910
KSLARRALGL INILRNG
Length:917
Mass (Da):102,500
Last modified:April 5, 2011 - v1
Checksum:i3986DB9EBD68189D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636486 Genomic DNA. Translation: EFW22289.1.

Genome annotation databases

EnsemblFungiiEFW22289; EFW22289; CPSG_00188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL636486 Genomic DNA. Translation: EFW22289.1.

3D structure databases

ProteinModelPortaliE9CUF4.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERicocp7-dapb. DPP4N_Peptidase_S9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEFW22289; EFW22289; CPSG_00188.

Phylogenomic databases

OrthoDBiEOG092C0PZJ.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B_N.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDAPB_COCPS
AccessioniPrimary (citable) accession number: E9CUF4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: September 7, 2016
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.