E9CTR7 (AMPP1_COCPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable Xaa-Pro aminopeptidase P
Short name=AMPP
Short name=Aminopeptidase P
EC=3.4.11.9

Alternative name(s):
Aminoacylproline aminopeptidase
Prolidase

Gene names

Name:	AMPP
ORF Names:	CPSG_00906

Organism

Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus) [Complete proteome]

Taxonomic identifier

443226 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Onygenales › mitosporic Onygenales › Coccidioides › Coccidioides posadasii

Protein attributes

Sequence length	611 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides By similarity.
Catalytic activity	Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.
Cofactor	Binds 2 manganese ions per subunit By similarity.
Sequence similarities	Belongs to the peptidase M24B family.

Ontologies

Keywords
Ligand	Manganese Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	cellular process Inferred from electronic annotation. Source: InterPro proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 611	611	Probable Xaa-Pro aminopeptidase P		PRO_0000411788
Sites
	Metal binding	408	1	Manganese 2 By similarity
	Metal binding	419	1	Manganese 1 By similarity
	Metal binding	419	1	Manganese 2 By similarity
	Metal binding	517	1	Manganese 1 By similarity
	Metal binding	531	1	Manganese 1 By similarity
	Metal binding	531	1	Manganese 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	E9CTR7 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: 3BE54F908636A4B8	FASTA	611	67,899
	10 20 30 40 50 60 MPVDTSQRLA KLRELMKERH VDVYLIPSED SHQSEYIAPC DARRAFISGF TGSAGCAIVS 70 80 90 100 110 120 MSKAALSTDG RYFNQAAKQL DENWLLLKRG MENVPTWQEW TAEQAEGGKV VGVDPSLITA 130 140 150 160 170 180 AEARKLSDTI KDTGGSLVGV PDNLVDLVWG GDRPARPREK VMVHPIEFAG QSFEEKITDL 190 200 210 220 230 240 RKELTKKKRA GMVISMLDEI AWLYNLRGAD IPFNPVFFAY AIVTHSTAEL FVDEAKLTQA 250 260 270 280 290 300 VKEHLGDKVA LRPYESIFES LKLLSQAAAS NGDEGHQKFL LSDKASWSLN LALGGEEKVE 310 320 330 340 350 360 EVRSPIADAK AVKNAVELEG TRACHIRDGA ALTEYFAWLE NELINKKTVL NEVNASDKLA 370 380 390 400 410 420 QIRSKHKDFV GLSFDTISST GPNAAIIHYR AERGNCPNID PNAVYLCDSG AQYLDGTTDT 430 440 450 460 470 480 TRTLHFGKPT EMEKKAYTLV LKGLISIDTA VFPKGTTGYA IDAFARQHLW RNGLDYLHGT 490 500 510 520 530 540 GHGVGSYLNV HEGPMGIGTR VQYAETPITA GNVLSDEPGY YEDGNFGIRI ENIVVAKEVK 550 560 570 580 590 600 TPHKFGDKPW IGFEHVTMTP LCQNLMDTSL LTAEEKKWVN DYHTEVWEKT KGFFNNDELT 610 RNWLKRETQP I

References

[1]

"The genome sequence of Coccidioides posadasii strain Silveira." The Broad Institute Genome Sequencing Center for Infectious Disease Neafsey D., Orbach M., Henn M.R., Cole G.T., Galgiani J., Gardner M.J., Kirkland T.N., Taylor J.W., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D., Chapman S.B., Chen Z., Engels R., Freedman E. , Gellesch M., Goldberg J., Griggs A., Gujja S., Heilman E., Heiman D., Howarth C., Jen D., Larson L., Mehta T., Neiman D., Park D., Pearson M., Richards J., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C., Haas B., Nusbaum C., Birren B. Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RMSCC 757 / Silveira.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GL636486 Genomic DNA. Translation: EFW23007.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.90.230.10. 1 hit.
InterPro	IPR000587. Creatinase. IPR000994. Pept_M24_structural-domain. IPR001131. Peptidase_M24B_aminopep-P_CS. [Graphical view]
Pfam	PF01321. Creatinase_N. 1 hit. PF00557. Peptidase_M24. 1 hit. [Graphical view]
SUPFAM	SSF55920. Peptidase_M24_cat_core. 1 hit.
PROSITE	PS00491. PROLINE_PEPTIDASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AMPP1_COCPS

Accession

Primary (citable) accession number: E9CTR7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	April 5, 2011
Last modified:	March 6, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program