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E9CS37

- KEX1_COCPS

UniProt

E9CS37 - KEX1_COCPS

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Protein

Pheromone-processing carboxypeptidase KEX1

Gene
KEX1, CPSG_01257
Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei188 – 1881 By similarity
Active sitei389 – 3891 By similarity
Active sitei451 – 4511 By similarity

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
ORF Names:CPSG_01257
OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Taxonomic identifieri443226 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000002497: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 522488Lumenal Reviewed predictionAdd
BLAST
Transmembranei523 – 54321Helical; Reviewed predictionAdd
BLAST
Topological domaini544 – 64198Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed predictionAdd
BLAST
Chaini35 – 641607Pheromone-processing carboxypeptidase KEX1PRO_0000411915Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi207 – 2071N-linked (GlcNAc...) Reviewed prediction
Glycosylationi440 – 4401N-linked (GlcNAc...) Reviewed prediction
Glycosylationi448 – 4481N-linked (GlcNAc...) Reviewed prediction
Glycosylationi500 – 5001N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi637 – 6415Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S10 family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

E9CS37-1 [UniParc]FASTAAdd to Basket

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MRSTSTFTRT PAFLLHTLAR WLLVWGVLGS SVVAEKKCAS NYYVRSLPGQ    50
PDGPLLKMHA GHVEVDHKNN GNLFFWHFQN RHIANRQRTV IWLNGGPGCS 100
SMDGALMEIG PYRLKDDHTL IYNEGSWDEF ANILFVDQPV GTGFSYVNTN 150
SYIHELDEMA SHFVTFLEKW FELFPEYEHD DLYFAGESYA GQYIPYIAKA 200
ILDRNKNTTT QAQSRLWNLK GLLIGNGWIS PVEQYQAYLT YAYKENLIQS 250
GTDAAKRVER AHSECISELD SGGKDRIHAG ACEKVLSAVL EVTRENGKCI 300
NMYDIRLRDE FPSCGMNWPP DLKHITPYLR RDDVISALHV NDDKRTGWRE 350
CTGAVSSNFN ARNSKPSVQL LPEILESGIP ITLFSGAKDF ICNHIGTEQF 400
IHNMQWSGGA GFELSPGVWA PRHDWTFEGE AAGYYQEARN LTYVLFYNAS 450
HMVPFDFGRR SRDMLDRFLG VDITSIGGNP ADSRIDGEKG ALTSVGNHPN 500
STTAEQREKE KLKAATWAAY YKSGEVALVV VAIAAAVWGF FIWRSRRQRQ 550
GSGYRGIYPN LNGLSSGSFS GFRNKRSSHD DIEAAADFDA SELDTLRGTD 600
DRSRGANGHG SVGGDSEDED EKFGAQKESY HPSNMPSSSS S 641
Length:641
Mass (Da):71,743
Last modified:April 5, 2011 - v1
Checksum:i3E4EF2B3168D4DDF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL636486 Genomic DNA. Translation: EFW23358.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL636486 Genomic DNA. Translation: EFW23358.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OrthoDBi EOG7TJ3SJ.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
[Graphical view ]
PANTHERi PTHR11802. PTHR11802. 1 hit.
Pfami PF00450. Peptidase_S10. 1 hit.
[Graphical view ]
PRINTSi PR00724. CRBOXYPTASEC.
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RMSCC 757 / Silveira.

Entry informationi

Entry nameiKEX1_COCPS
AccessioniPrimary (citable) accession number: E9CS37
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi