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E9CS37

- KEX1_COCPS

UniProt

E9CS37 - KEX1_COCPS

Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Coccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death By similarity.By similarity

    Catalytic activityi

    Preferential release of a C-terminal arginine or lysine residue.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei188 – 1881By similarity
    Active sitei389 – 3891By similarity
    Active sitei451 – 4511By similarity

    GO - Molecular functioni

    1. serine-type carboxypeptidase activity Source: InterPro

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Carboxypeptidase, Hydrolase, Protease

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
    Alternative name(s):
    Carboxypeptidase D
    Gene namesi
    Name:KEX1
    ORF Names:CPSG_01257
    OrganismiCoccidioides posadasii (strain RMSCC 757 / Silveira) (Valley fever fungus)
    Taxonomic identifieri443226 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
    ProteomesiUP000002497: Unassembled WGS sequence

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi apparatus Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 641607Pheromone-processing carboxypeptidase KEX1PRO_0000411915Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi207 – 2071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi440 – 4401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi448 – 4481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 522488LumenalSequence AnalysisAdd
    BLAST
    Topological domaini544 – 64198CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei523 – 54321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi637 – 6415Poly-Ser

    Sequence similaritiesi

    Belongs to the peptidase S10 family.Curated

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7TJ3SJ.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view]
    PANTHERiPTHR11802. PTHR11802. 1 hit.
    PfamiPF00450. Peptidase_S10. 1 hit.
    [Graphical view]
    PRINTSiPR00724. CRBOXYPTASEC.
    SUPFAMiSSF53474. SSF53474. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    E9CS37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRSTSTFTRT PAFLLHTLAR WLLVWGVLGS SVVAEKKCAS NYYVRSLPGQ    50
    PDGPLLKMHA GHVEVDHKNN GNLFFWHFQN RHIANRQRTV IWLNGGPGCS 100
    SMDGALMEIG PYRLKDDHTL IYNEGSWDEF ANILFVDQPV GTGFSYVNTN 150
    SYIHELDEMA SHFVTFLEKW FELFPEYEHD DLYFAGESYA GQYIPYIAKA 200
    ILDRNKNTTT QAQSRLWNLK GLLIGNGWIS PVEQYQAYLT YAYKENLIQS 250
    GTDAAKRVER AHSECISELD SGGKDRIHAG ACEKVLSAVL EVTRENGKCI 300
    NMYDIRLRDE FPSCGMNWPP DLKHITPYLR RDDVISALHV NDDKRTGWRE 350
    CTGAVSSNFN ARNSKPSVQL LPEILESGIP ITLFSGAKDF ICNHIGTEQF 400
    IHNMQWSGGA GFELSPGVWA PRHDWTFEGE AAGYYQEARN LTYVLFYNAS 450
    HMVPFDFGRR SRDMLDRFLG VDITSIGGNP ADSRIDGEKG ALTSVGNHPN 500
    STTAEQREKE KLKAATWAAY YKSGEVALVV VAIAAAVWGF FIWRSRRQRQ 550
    GSGYRGIYPN LNGLSSGSFS GFRNKRSSHD DIEAAADFDA SELDTLRGTD 600
    DRSRGANGHG SVGGDSEDED EKFGAQKESY HPSNMPSSSS S 641
    Length:641
    Mass (Da):71,743
    Last modified:April 5, 2011 - v1
    Checksum:i3E4EF2B3168D4DDF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL636486 Genomic DNA. Translation: EFW23358.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL636486 Genomic DNA. Translation: EFW23358.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    OrthoDBi EOG7TJ3SJ.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR001563. Peptidase_S10.
    [Graphical view ]
    PANTHERi PTHR11802. PTHR11802. 1 hit.
    Pfami PF00450. Peptidase_S10. 1 hit.
    [Graphical view ]
    PRINTSi PR00724. CRBOXYPTASEC.
    SUPFAMi SSF53474. SSF53474. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RMSCC 757 / Silveira.

    Entry informationi

    Entry nameiKEX1_COCPS
    AccessioniPrimary (citable) accession number: E9CS37
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3