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Protein
Submitted name:

2-oxoglutarate dehydrogenase subunit, putative

Gene

LDBPK_270740

Organism
Leishmania donovani (strain BPK282A1)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: InterPro
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
2-oxoglutarate dehydrogenase subunit, putativeImported
Gene namesi
ORF Names:LDBPK_270740Imported
OrganismiLeishmania donovani (strain BPK282A1)Imported
Taxonomic identifieri981087 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000008980: Chromosome 27

Structurei

3D structure databases

ProteinModelPortaliE9BJ08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000259586.
KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

E9BJ08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMRRALSGAV AVRASAMRSY TDARTIRKPN PYDQLVNAEN QHYVEDLMRQ
60 70 80 90 100
YEADSALVDP SWVPVLEAIR SGSDDSPVVA TFSRPTDAKS LSEKQRHDNM
110 120 130 140 150
RLSWMIREYE RFGHHMANVD PLSGYHADNR ILGSRTLAPE EFGFTKDDLT
160 170 180 190 200
HVFNVTFGAS HEATFVSGGT AMTLQQIIDQ LRRLYCGPIG FEFMSSGFFE
210 220 230 240 250
LRNWFRQEVM DSLQPLPAEE RRLYYNDVVK ACGFEKFLQL KYATKHRFGL
260 270 280 290 300
DGGEALIPAL KAAILTSSDL GVQSAIIGMA HRGRLNVLAN VLRKSLRAIL
310 320 330 340 350
NEFEGRVAIE DAHLTGDVEY HLGKRKHVKL PNNKSIELDL LPNPSHLEAV
360 370 380 390 400
NPLVLGKARA RQIYTNDVEC TAVLPILIHG DAAFAGQGSC YETMGFCELE
410 420 430 440 450
NFHVGGTLHL VINNQIGFTT NPKDSRASAY CTDLSKVNNA PVMHVNGDDV
460 470 480 490 500
DACVKAAKIA ARFRQQFHHD IIIDLVCYRR YGHNETDLPD FTQPQLYNQI
510 520 530 540 550
RQHPSVVDIY TKTLIRDGVL TAEEAKAKDK EWEGVLRQAY DRMNSAQNFV
560 570 580 590 600
KVMPVFDPES ENTSADLSYA KIAATRVPPP VSAVDTGVET QTLRMAGLRL
610 620 630 640 650
ASIPKEMQKP HPVVERTYAA RKKGTEQGDA IEWCQAELMA LATLSMQGVP
660 670 680 690 700
IRLTGEDVER GTFTQRHAGI TDMKTNLKYF PVKTLSPSQA LITISNSSLS
710 720 730 740 750
ELGVCGFEMG YNMENTRSIT IWEAQFGDFA NGAQVIFDQF LSCCEEKWNE
760 770 780 790 800
HSSLVLSLPH GYSGAGPEHS SARVERFLQL SDDGDRVPSD FRHFPNDQAL
810 820 830 840 850
EIRIRRHNWQ VTYPSTPANY FHLLRRQGLR EFAKPLINFF SKARLRAPNL
860 870 880 890 900
SKLSDMTQGT SFKAVIDTAR AKDTVARKVV FCSGQIESIV NDAKAARQKE
910 920 930 940 950
TPGVHDDVVL VTVEQLAPFP WEQVADVMEK YAQRNLNTEF VWLQEEPRNM
960 970 980 990 1000
GMWTHMRPRM NSLMHHLGLK QKRINVVSRP SAASPSTGYG SVHVAEEKKL

IAETLA
Length:1,006
Mass (Da):112,904
Last modified:April 5, 2011 - v1
Checksum:i18A1BF0137390DCF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799614 Genomic DNA. Translation: CBZ35234.1.
RefSeqiXP_003861930.1. XM_003861882.1.

Genome annotation databases

GeneIDi13389191.
KEGGildo:LDBPK_270740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799614 Genomic DNA. Translation: CBZ35234.1.
RefSeqiXP_003861930.1. XM_003861882.1.

3D structure databases

ProteinModelPortaliE9BJ08.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13389191.
KEGGildo:LDBPK_270740.

Phylogenomic databases

HOGENOMiHOG000259586.
KOiK00164.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance."
    Downing T., Imamura H., Sanders M., Decuypere S., Hertz-Fowler C., Clark T.G., Rijal S., Sundar S., Quail M.A., De Doncker S., Maes I., Vanaerschot M., Stark O., Schonian G., Dujardin J.C., Berriman M.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BPK282A1Imported.

Entry informationi

Entry nameiE9BJ08_LEIDB
AccessioniPrimary (citable) accession number: E9BJ08
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: January 7, 2015
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.