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Protein

Histone deacetylase

Gene

LDBPK_210740

Organism
Leishmania donovani (strain BPK282A1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei113SubstrateUniRule annotation1
Active sitei155Proton acceptorUniRule annotation1
Binding sitei163Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi190Divalent metal cationUniRule annotation1
Metal bindingi192Divalent metal cationUniRule annotation1
Metal bindingi279Divalent metal cationUniRule annotation1
Binding sitei318SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:LDBPK_210740Imported
OrganismiLeishmania donovani (strain BPK282A1)Imported
Taxonomic identifieri981087 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000008980 Componenti: Chromosome 21

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi5661.XP_003860591.1.

Structurei

3D structure databases

ProteinModelPortaliE9BF59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini43 – 334Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
KOiK06067.
OMAiQNTNDYL.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
IPR037138. His_deacetylse_dom_sf.
IPR023696. Ureohydrolase_dom_sf.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
SUPFAMiSSF52768. SSF52768. 1 hit.

Sequencei

Sequence statusi: Complete.

E9BF59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHAVHKDDAR APLLNTESRC RVALIDTSGY ASDMNISAFV PQHAMKPYRV
60 70 80 90 100
LAAMEIVRSL KIDAHCRTVV PPLVKVEELM AYHTDTYLAN LGLHSCRSWL
110 120 130 140 150
WNAETSKVFF SGDCPPVEGL MEHSIATASG TLMGAVLLNS GQVDVAVHWG
160 170 180 190 200
GGMHHSKCGE CSGFCYVNDI VLGILELLKC HDRVLYVDID MHHGDGVDEA
210 220 230 240 250
FCTSDRVFTL SLHKFGESFF PGTGHPRDVG YGRGRYYSMN LAVWDGITDF
260 270 280 290 300
YYLGVFEHAL HSIVRRYSPD VIVLQCGADS LAGDRLGLLN LSSFGHGQCV
310 320 330 340 350
QAVRDLGIPM LALGGGGYTI RNVAKLWAYE TSILTGHPLP PNTVLPVAEM
360 370 380 390 400
PLSGWLFQDS PLLIVAQDRS NHVLPGLHCQ RAYQMMTEQI DRHVPHIQPH
410 420 430
PRLQKASTEA AAVDKQVEDG TTAVEDFKRQ
Length:430
Mass (Da):47,389
Last modified:April 5, 2011 - v1
Checksum:i0E5EA4D37A4C8459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799608 Genomic DNA. Translation: CBZ33885.1.
RefSeqiXP_003860591.1. XM_003860543.1.

Genome annotation databases

EnsemblProtistsiCBZ33885; CBZ33885; LDBPK_210740.
GeneDBiLdBPK_210740.1.1:pep.
GeneIDi13386404.
KEGGildo:LDBPK_210740.

Similar proteinsi

Entry informationi

Entry nameiE9BF59_LEIDB
AccessioniPrimary (citable) accession number: E9BF59
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 22, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported