Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

E9BF59

- E9BF59_LEIDB

UniProt

E9BF59 - E9BF59_LEIDB

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone deacetylase

Gene

LDBPK_210740

Organism
Leishmania donovani (strain BPK282A1)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:LDBPK_210740Imported
OrganismiLeishmania donovani (strain BPK282A1)Imported
Taxonomic identifieri981087 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000008980: Chromosome 21

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE9BF59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

E9BF59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHAVHKDDAR APLLNTESRC RVALIDTSGY ASDMNISAFV PQHAMKPYRV
60 70 80 90 100
LAAMEIVRSL KIDAHCRTVV PPLVKVEELM AYHTDTYLAN LGLHSCRSWL
110 120 130 140 150
WNAETSKVFF SGDCPPVEGL MEHSIATASG TLMGAVLLNS GQVDVAVHWG
160 170 180 190 200
GGMHHSKCGE CSGFCYVNDI VLGILELLKC HDRVLYVDID MHHGDGVDEA
210 220 230 240 250
FCTSDRVFTL SLHKFGESFF PGTGHPRDVG YGRGRYYSMN LAVWDGITDF
260 270 280 290 300
YYLGVFEHAL HSIVRRYSPD VIVLQCGADS LAGDRLGLLN LSSFGHGQCV
310 320 330 340 350
QAVRDLGIPM LALGGGGYTI RNVAKLWAYE TSILTGHPLP PNTVLPVAEM
360 370 380 390 400
PLSGWLFQDS PLLIVAQDRS NHVLPGLHCQ RAYQMMTEQI DRHVPHIQPH
410 420 430
PRLQKASTEA AAVDKQVEDG TTAVEDFKRQ
Length:430
Mass (Da):47,389
Last modified:April 5, 2011 - v1
Checksum:i0E5EA4D37A4C8459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799608 Genomic DNA. Translation: CBZ33885.1.
RefSeqiXP_003860591.1. XM_003860543.1.

Genome annotation databases

GeneIDi13386404.
KEGGildo:LDBPK_210740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799608 Genomic DNA. Translation: CBZ33885.1 .
RefSeqi XP_003860591.1. XM_003860543.1.

3D structure databases

ProteinModelPortali E9BF59.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 13386404.
KEGGi ldo:LDBPK_210740.

Phylogenomic databases

HOGENOMi HOG000225180.
KOi K06067.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance."
    Downing T., Imamura H., Sanders M., Decuypere S., Hertz-Fowler C., Clark T.G., Rijal S., Sundar S., Quail M.A., De Doncker S., Maes I., Vanaerschot M., Stark O., Schonian G., Dujardin J.C., Berriman M.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BPK282A1Imported.

Entry informationi

Entry nameiE9BF59_LEIDB
AccessioniPrimary (citable) accession number: E9BF59
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 1, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3