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Protein

Histone deacetylase

Gene

LDBPK_210740

Organism
Leishmania donovani (strain BPK282A1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:LDBPK_210740Imported
OrganismiLeishmania donovani (strain BPK282A1)Imported
Taxonomic identifieri981087 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000008980 Componenti: Chromosome 21

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE9BF59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000225180.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

E9BF59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHAVHKDDAR APLLNTESRC RVALIDTSGY ASDMNISAFV PQHAMKPYRV
60 70 80 90 100
LAAMEIVRSL KIDAHCRTVV PPLVKVEELM AYHTDTYLAN LGLHSCRSWL
110 120 130 140 150
WNAETSKVFF SGDCPPVEGL MEHSIATASG TLMGAVLLNS GQVDVAVHWG
160 170 180 190 200
GGMHHSKCGE CSGFCYVNDI VLGILELLKC HDRVLYVDID MHHGDGVDEA
210 220 230 240 250
FCTSDRVFTL SLHKFGESFF PGTGHPRDVG YGRGRYYSMN LAVWDGITDF
260 270 280 290 300
YYLGVFEHAL HSIVRRYSPD VIVLQCGADS LAGDRLGLLN LSSFGHGQCV
310 320 330 340 350
QAVRDLGIPM LALGGGGYTI RNVAKLWAYE TSILTGHPLP PNTVLPVAEM
360 370 380 390 400
PLSGWLFQDS PLLIVAQDRS NHVLPGLHCQ RAYQMMTEQI DRHVPHIQPH
410 420 430
PRLQKASTEA AAVDKQVEDG TTAVEDFKRQ
Length:430
Mass (Da):47,389
Last modified:April 5, 2011 - v1
Checksum:i0E5EA4D37A4C8459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799608 Genomic DNA. Translation: CBZ33885.1.
RefSeqiXP_003860591.1. XM_003860543.1.

Genome annotation databases

GeneIDi13386404.
KEGGildo:LDBPK_210740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR799608 Genomic DNA. Translation: CBZ33885.1.
RefSeqiXP_003860591.1. XM_003860543.1.

3D structure databases

ProteinModelPortaliE9BF59.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13386404.
KEGGildo:LDBPK_210740.

Phylogenomic databases

HOGENOMiHOG000225180.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequencing of Leishmania donovani clinical lines reveals dynamic variation related to drug resistance."
    Downing T., Imamura H., Sanders M., Decuypere S., Hertz-Fowler C., Clark T.G., Rijal S., Sundar S., Quail M.A., De Doncker S., Maes I., Vanaerschot M., Stark O., Schonian G., Dujardin J.C., Berriman M.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: BPK282A1Imported.

Entry informationi

Entry nameiE9BF59_LEIDB
AccessioniPrimary (citable) accession number: E9BF59
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 27, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.