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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

LINJ_24_1700

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathway: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (LINJ_24_1700)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Electron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

FADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:LINJ_24_1700Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
ProteomesiUP000008153 Componenti: Chromosome 24

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi435258.XP_003392571.1.

Structurei

3D structure databases

ProteinModelPortaliE9AH70.
SMRiE9AH70. Positions 15-607.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

InParanoidiE9AH70.
KOiK00234.
OMAiKWRTCFT.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E9AH70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRTFTRLA LSRAYPVIDH TYDCVVVGAG GSGLRAAMGV AASGYDVACI
60 70 80 90 100
SKLYPSRSHT IAAQGGINAA LANCEEDDWR WHVYDTVKGS DWLGDQDAIQ
110 120 130 140 150
YMCQEAPCVV SELESMGLPF LRTKDGFIYQ RAFGGQSIHY GGKQARRTCA
160 170 180 190 200
ASDRTGHAML HTLYGQSFQY GVNFYNEYYC LDLIMEDGCC RGVMAMSIDD
210 220 230 240 250
GTIHRFKSKY TVLCTGGYGR VYFTTTSAKS CTGDGTAMVA RAGLPAEDME
260 270 280 290 300
FVQFHPTGIY GPGVLITEGA RGEGGYLVNS EGERFMERYA PKAKDLASRD
310 320 330 340 350
VVSRAITMEI LAGRGCGPKK DHVMLQLHHL DPATLHKKLP GISESAHIFA
360 370 380 390 400
GVDVTKEPIP IVPTVHYSMG GVPTLWTGEV ISPRNGDDNA IVPGLLAAGE
410 420 430 440 450
CACASVHGAN RLGANSLLDI VVFGKSCANT VIFNLTKEGR KQPELRADAG
460 470 480 490 500
EASIADLDRI LNNKGDIPIA RIRERMKETM ALYAAVFRTE ESMQTGKKII
510 520 530 540 550
EECYRDFSHA FVHDKSPVWN SNLIEALELR NLLTNAMMTI SGAVVRKESR
560 570 580 590 600
GAHARDDYQE RDDHNWMKHT LAYLDDAKGK VRLAYRPVHM EMLTNEVESI

PPAKRVY
Length:607
Mass (Da):66,741
Last modified:April 5, 2011 - v1
Checksum:i07CEA74CB46979A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796456 Genomic DNA. Translation: CBZ08739.1.
RefSeqiXP_003392571.1. XM_003392523.1.

Genome annotation databases

GeneIDi10966264.
KEGGilif:LINJ_24_1700.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796456 Genomic DNA. Translation: CBZ08739.1.
RefSeqiXP_003392571.1. XM_003392523.1.

3D structure databases

ProteinModelPortaliE9AH70.
SMRiE9AH70. Positions 15-607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi435258.XP_003392571.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi10966264.
KEGGilif:LINJ_24_1700.

Phylogenomic databases

InParanoidiE9AH70.
KOiK00234.
OMAiKWRTCFT.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JPCM5Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JPCM5Imported.
  3. "Chromosome and gene copy number variation allow genomic structural differences between species and strains of Leishmania."
    Hilley J.D., Rogers M., Wilkes J., Dickens N.J., Bates P., Depledge D.P., Harris D., Her Y., Herzyk P., Imamura H., Otto T.D., Saad W., Seeger K., Berriman M., Smith D.F., Hertz-Fowler C., Mottram J.C.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JPCM5.

Entry informationi

Entry nameiE9AH70_LEIIN
AccessioniPrimary (citable) accession number: E9AH70
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 24, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.