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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

LINJ_24_1700

Organism
Leishmania infantum
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (LINJ_24_1700)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:LINJ_24_1700Imported
OrganismiLeishmania infantumImported
Taxonomic identifieri5671 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeLeishmaniinaeLeishmania
Proteomesi
  • UP000008153 Componenti: Chromosome 24

Organism-specific databases

EuPathDBiTriTrypDB:LinJ.24.1700

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi435258.XP_003392571.1

Structurei

3D structure databases

ProteinModelPortaliE9AH70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403 Eukaryota
COG1053 LUCA
InParanoidiE9AH70
KOiK00234
OMAiGDSPWEH

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

E9AH70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRRTFTRLA LSRAYPVIDH TYDCVVVGAG GSGLRAAMGV AASGYDVACI
60 70 80 90 100
SKLYPSRSHT IAAQGGINAA LANCEEDDWR WHVYDTVKGS DWLGDQDAIQ
110 120 130 140 150
YMCQEAPCVV SELESMGLPF LRTKDGFIYQ RAFGGQSIHY GGKQARRTCA
160 170 180 190 200
ASDRTGHAML HTLYGQSFQY GVNFYNEYYC LDLIMEDGCC RGVMAMSIDD
210 220 230 240 250
GTIHRFKSKY TVLCTGGYGR VYFTTTSAKS CTGDGTAMVA RAGLPAEDME
260 270 280 290 300
FVQFHPTGIY GPGVLITEGA RGEGGYLVNS EGERFMERYA PKAKDLASRD
310 320 330 340 350
VVSRAITMEI LAGRGCGPKK DHVMLQLHHL DPATLHKKLP GISESAHIFA
360 370 380 390 400
GVDVTKEPIP IVPTVHYSMG GVPTLWTGEV ISPRNGDDNA IVPGLLAAGE
410 420 430 440 450
CACASVHGAN RLGANSLLDI VVFGKSCANT VIFNLTKEGR KQPELRADAG
460 470 480 490 500
EASIADLDRI LNNKGDIPIA RIRERMKETM ALYAAVFRTE ESMQTGKKII
510 520 530 540 550
EECYRDFSHA FVHDKSPVWN SNLIEALELR NLLTNAMMTI SGAVVRKESR
560 570 580 590 600
GAHARDDYQE RDDHNWMKHT LAYLDDAKGK VRLAYRPVHM EMLTNEVESI

PPAKRVY
Length:607
Mass (Da):66,741
Last modified:April 5, 2011 - v1
Checksum:i07CEA74CB46979A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FR796456 Genomic DNA Translation: CBZ08739.1
RefSeqiXP_003392571.1, XM_003392523.1

Genome annotation databases

EnsemblProtistsiCBZ08739; CBZ08739; LINJ_24_1700
GeneDBiLinJ.24.1700:pep
GeneIDi10966264
KEGGilif:LINJ_24_1700

Similar proteinsi

Entry informationi

Entry nameiE9AH70_LEIIN
AccessioniPrimary (citable) accession number: E9AH70
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: April 25, 2018
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health