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E8YVP3

- E8YVP3_9BURK

UniProt

E8YVP3 - E8YVP3_9BURK

Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

BC1001_4557

Organism
Burkholderia sp. CCGE1001
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei146 – 1461SubstrateUniRule annotation
    Sitei256 – 2561Critical for catalysis
    Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
    Sitei421 – 4211Critical for catalysisUniRule annotation
    Binding sitei548 – 5481SubstrateUniRule annotation
    Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
    Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciBSP640510:GI28-4626-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
    Gene namesi
    ORF Names:BC1001_4557Imported
    OrganismiBurkholderia sp. CCGE1001Imported
    Taxonomic identifieri640510 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
    ProteomesiUP000007095: Chromosome 2

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni133 – 1408Substrate bindingUniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 3 hits.
    InterProiIPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PfamiPF03971. IDH. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8YVP3-1 [UniParc]FASTAAdd to Basket

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    MSTPPKIIYT LTDEAPALAT YSLLPIVKAF TRSSGVNVET RDISLAGRII    50
    AAFPDYLSPE QKGSDDLAEL GGLTTRPEAN IIKLPNISAS VPQLKAAITE 100
    LRDQGYKLPP YPDVATTDTE KDVKARYDKI KGSAVNPVLR EGNSDRRAPL 150
    SVKNYARKHP HKMGAWTADS KSHVAHMSGG DFYGSEKSAL IAAAGAVKIE 200
    LTAADGTKTV LKEKTPVQAG EVIDASVLSK NALRSFIEKE ISDAKANGVL 250
    FSVHLKATMM KVSDPIIFGH VVSVFYKDVL TKHADALAQA GFNPNNGIGD 300
    LYARLKDLPA ETAAQIEADI KAQYEQRPQL AMVNSDKGIT SLHVPSDVIV 350
    DASMPAMIRE SGKMWGADGA LHDAKAVIPD RCYAGVYQAV IEDCKKNGAF 400
    DPVTMGTVPN VGLMAQAAEE YGSHDKTFQI PANGVVRVTD ASGAVLIEQP 450
    VEAGDIWRMC QTKDAPVQDW VKLAVNRARA TNTPAVFWLD AARAHDAQII 500
    KKVEQYLKDH DTNGLDIRIM TPVEATKFSL ERIRAGKDTI SVTGNVLRDY 550
    LTDLFPIMEL GTSAKMLSIV PLMAGGGMFE TGAGGSAPKH VQQLVEEGFL 600
    RWDSLGEFLA LAASLEHLSS AYHNPKAQVL AKTLDQATGK FLDNDKSPAR 650
    KVGGLDNRGS HFYLAMYWAE ALAEQTEDAA LQAQFAGVAK AMAANEAKIL 700
    EELRAAQGKP VDIGGYYRPN VELTSKAMRP SATLNQIVDS IA 742
    Length:742
    Mass (Da):79,907
    Last modified:April 5, 2011 - v1
    Checksum:iA171ADEEF9833659
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002520 Genomic DNA. Translation: ADX57946.1.
    RefSeqiWP_013591051.1. NC_015137.1.
    YP_004231006.1. NC_015137.1.

    Genome annotation databases

    EnsemblBacteriaiADX57946; ADX57946; BC1001_4557.
    GeneIDi10226149.
    KEGGibug:BC1001_4557.
    PATRICi46902192. VBIBurSp1058_4767.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002520 Genomic DNA. Translation: ADX57946.1 .
    RefSeqi WP_013591051.1. NC_015137.1.
    YP_004231006.1. NC_015137.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADX57946 ; ADX57946 ; BC1001_4557 .
    GeneIDi 10226149.
    KEGGi bug:BC1001_4557.
    PATRICi 46902192. VBIBurSp1058_4767.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci BSP640510:GI28-4626-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 3 hits.
    InterProi IPR004436. Isocitrate_DH_NADP_mono.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    Pfami PF03971. IDH. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009407. IDH_monmr. 1 hit.
    TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CCGE1001Imported.

    Entry informationi

    Entry nameiE8YVP3_9BURK
    AccessioniPrimary (citable) accession number: E8YVP3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3