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E8YVP3

- E8YVP3_9BURK

UniProt

E8YVP3 - E8YVP3_9BURK

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Protein
Submitted name:

Isocitrate dehydrogenase, NADP-dependent

Gene

BC1001_4557

Organism
Burkholderia sp. CCGE1001
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei146 – 1461SubstrateUniRule annotation
Sitei256 – 2561Critical for catalysis
Metal bindingi351 – 3511Magnesium or manganeseUniRule annotation
Sitei421 – 4211Critical for catalysisUniRule annotation
Binding sitei548 – 5481SubstrateUniRule annotation
Metal bindingi549 – 5491Magnesium or manganeseUniRule annotation
Metal bindingi553 – 5531Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBSP640510:GI28-4626-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase, NADP-dependentImported (EC:1.1.1.42Imported)
Gene namesi
ORF Names:BC1001_4557Imported
OrganismiBurkholderia sp. CCGE1001Imported
Taxonomic identifieri640510 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000007095: Chromosome 2

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 1408Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

E8YVP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTPPKIIYT LTDEAPALAT YSLLPIVKAF TRSSGVNVET RDISLAGRII
60 70 80 90 100
AAFPDYLSPE QKGSDDLAEL GGLTTRPEAN IIKLPNISAS VPQLKAAITE
110 120 130 140 150
LRDQGYKLPP YPDVATTDTE KDVKARYDKI KGSAVNPVLR EGNSDRRAPL
160 170 180 190 200
SVKNYARKHP HKMGAWTADS KSHVAHMSGG DFYGSEKSAL IAAAGAVKIE
210 220 230 240 250
LTAADGTKTV LKEKTPVQAG EVIDASVLSK NALRSFIEKE ISDAKANGVL
260 270 280 290 300
FSVHLKATMM KVSDPIIFGH VVSVFYKDVL TKHADALAQA GFNPNNGIGD
310 320 330 340 350
LYARLKDLPA ETAAQIEADI KAQYEQRPQL AMVNSDKGIT SLHVPSDVIV
360 370 380 390 400
DASMPAMIRE SGKMWGADGA LHDAKAVIPD RCYAGVYQAV IEDCKKNGAF
410 420 430 440 450
DPVTMGTVPN VGLMAQAAEE YGSHDKTFQI PANGVVRVTD ASGAVLIEQP
460 470 480 490 500
VEAGDIWRMC QTKDAPVQDW VKLAVNRARA TNTPAVFWLD AARAHDAQII
510 520 530 540 550
KKVEQYLKDH DTNGLDIRIM TPVEATKFSL ERIRAGKDTI SVTGNVLRDY
560 570 580 590 600
LTDLFPIMEL GTSAKMLSIV PLMAGGGMFE TGAGGSAPKH VQQLVEEGFL
610 620 630 640 650
RWDSLGEFLA LAASLEHLSS AYHNPKAQVL AKTLDQATGK FLDNDKSPAR
660 670 680 690 700
KVGGLDNRGS HFYLAMYWAE ALAEQTEDAA LQAQFAGVAK AMAANEAKIL
710 720 730 740
EELRAAQGKP VDIGGYYRPN VELTSKAMRP SATLNQIVDS IA
Length:742
Mass (Da):79,907
Last modified:April 5, 2011 - v1
Checksum:iA171ADEEF9833659
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002520 Genomic DNA. Translation: ADX57946.1.
RefSeqiWP_013591051.1. NC_015137.1.
YP_004231006.1. NC_015137.1.

Genome annotation databases

EnsemblBacteriaiADX57946; ADX57946; BC1001_4557.
GeneIDi10226149.
KEGGibug:BC1001_4557.
PATRICi46902192. VBIBurSp1058_4767.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002520 Genomic DNA. Translation: ADX57946.1 .
RefSeqi WP_013591051.1. NC_015137.1.
YP_004231006.1. NC_015137.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADX57946 ; ADX57946 ; BC1001_4557 .
GeneIDi 10226149.
KEGGi bug:BC1001_4557.
PATRICi 46902192. VBIBurSp1058_4767.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci BSP640510:GI28-4626-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 3 hits.
InterProi IPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
Pfami PF03971. IDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsi TIGR00178. monomer_idh. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCGE1001Imported.

Entry informationi

Entry nameiE8YVP3_9BURK
AccessioniPrimary (citable) accession number: E8YVP3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3