E8YVP3 (E8YVP3_9BURK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Isocitrate dehydrogenase, NADP-dependent EMBL ADX57946.1
EC=1.1.1.42 EMBL ADX57946.1

Gene names

ORF Names:

BC1001_4557 EMBL ADX57946.1

Organism

Burkholderia sp. CCGE1001 EMBL ADX57946.1

Taxonomic identifier

640510 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length	742 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR009407-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR009407-3 Metal-binding PIRSR PIRSR009407-3
Molecular function	Oxidoreductase EMBL ADX57946.1
Gene Ontology (GO)
Biological_process	tricarboxylic acid cycle Inferred from electronic annotation. Source: InterPro
Molecular_function	isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	133 – 140	8	Substrate binding By similarity PIRSR PIRSR009407-2
Sites
	Metal binding	351	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	549	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Metal binding	553	1	Magnesium or manganese By similarity PIRSR PIRSR009407-3
	Binding site	146	1	Substrate By similarity PIRSR PIRSR009407-2
	Binding site	548	1	Substrate By similarity PIRSR PIRSR009407-2
	Site	256	1	Critical for catalysis By similarity PIRSR PIRSR009407-1
	Site	421	1	Critical for catalysis By similarity PIRSR PIRSR009407-1

Sequences

	Sequence		Length	Mass (Da)
	E8YVP3 [UniParc]. Last modified April 5, 2011. Version 1. Checksum: A171ADEEF9833659	FASTA	742	79,907
	10 20 30 40 50 60 MSTPPKIIYT LTDEAPALAT YSLLPIVKAF TRSSGVNVET RDISLAGRII AAFPDYLSPE 70 80 90 100 110 120 QKGSDDLAEL GGLTTRPEAN IIKLPNISAS VPQLKAAITE LRDQGYKLPP YPDVATTDTE 130 140 150 160 170 180 KDVKARYDKI KGSAVNPVLR EGNSDRRAPL SVKNYARKHP HKMGAWTADS KSHVAHMSGG 190 200 210 220 230 240 DFYGSEKSAL IAAAGAVKIE LTAADGTKTV LKEKTPVQAG EVIDASVLSK NALRSFIEKE 250 260 270 280 290 300 ISDAKANGVL FSVHLKATMM KVSDPIIFGH VVSVFYKDVL TKHADALAQA GFNPNNGIGD 310 320 330 340 350 360 LYARLKDLPA ETAAQIEADI KAQYEQRPQL AMVNSDKGIT SLHVPSDVIV DASMPAMIRE 370 380 390 400 410 420 SGKMWGADGA LHDAKAVIPD RCYAGVYQAV IEDCKKNGAF DPVTMGTVPN VGLMAQAAEE 430 440 450 460 470 480 YGSHDKTFQI PANGVVRVTD ASGAVLIEQP VEAGDIWRMC QTKDAPVQDW VKLAVNRARA 490 500 510 520 530 540 TNTPAVFWLD AARAHDAQII KKVEQYLKDH DTNGLDIRIM TPVEATKFSL ERIRAGKDTI 550 560 570 580 590 600 SVTGNVLRDY LTDLFPIMEL GTSAKMLSIV PLMAGGGMFE TGAGGSAPKH VQQLVEEGFL 610 620 630 640 650 660 RWDSLGEFLA LAASLEHLSS AYHNPKAQVL AKTLDQATGK FLDNDKSPAR KVGGLDNRGS 670 680 690 700 710 720 HFYLAMYWAE ALAEQTEDAA LQAQFAGVAK AMAANEAKIL EELRAAQGKP VDIGGYYRPN 730 740 VELTSKAMRP SATLNQIVDS IA

References

[1]

"Complete sequence of chromosome2 of Burkholderia sp. CCGE1001." US DOE Joint Genome Institute Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Martinez-Romero E. , Rogel M.A., Auchtung J., Tiedje J., Woyke T. Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: CCGE1001 EMBL ADX57946.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP002520 Genomic DNA. Translation: ADX57946.1.
RefSeq	YP_004231006.1. NC_015137.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ADX57946; ADX57946; BC1001_4557.
GeneID	10226149.
KEGG	bug:BC1001_4557.
PATRIC	46902192. VBIBurSp1058_4767.
Phylogenomic databases
KO	K00031.
Enzyme and pathway databases
BioCyc	BSP640510:GI28-956-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 3 hits.
InterPro	IPR004436. Isocitrate_DH_NADP_mono. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
Pfam	PF03971. IDH. 1 hit. [Graphical view]
PIRSF	PIRSF009407. IDH_monmr. 1 hit.
TIGRFAMs	TIGR00178. monomer_idh. 1 hit.
ProtoNet	Search...

Entry information

Entry name

E8YVP3_9BURK

Accession

Primary (citable) accession number: E8YVP3

Entry history

Integrated into UniProtKB/TrEMBL:	April 5, 2011
Last sequence update:	April 5, 2011
Last modified:	April 3, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)