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E8YSE3

- E8YSE3_9BURK

UniProt

E8YSE3 - E8YSE3_9BURK

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Protein

Ribulose bisphosphate carboxylase large chain

Gene

cbbL

Organism
Burkholderia sp. CCGE1001
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

RuBisCO catalyzes two reactions: the carboxylation of D-ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site.UniRule annotation

Catalytic activityi

2 3-phospho-D-glycerate + 2 H+ = D-ribulose 1,5-bisphosphate + CO2 + H2O.UniRule annotation
3-phospho-D-glycerate + 2-phosphoglycolate = D-ribulose 1,5-bisphosphate + O2.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei139 – 1391Substrate; in homodimeric partnerUniRule annotation
Binding sitei189 – 1891SubstrateUniRule annotation
Active sitei191 – 1911Proton acceptorUniRule annotation
Binding sitei193 – 1931SubstrateUniRule annotation
Metal bindingi217 – 2171Magnesium; via carbamate groupUniRule annotation
Metal bindingi219 – 2191MagnesiumUniRule annotation
Metal bindingi220 – 2201MagnesiumUniRule annotation
Active sitei309 – 3091Proton acceptorUniRule annotation
Binding sitei310 – 3101SubstrateUniRule annotation
Binding sitei342 – 3421SubstrateUniRule annotation
Sitei349 – 3491Transition state stabilizerUniRule annotation
Binding sitei394 – 3941SubstrateUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. monooxygenase activity Source: UniProtKB-KW
  3. ribulose-bisphosphate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. reductive pentose-phosphate cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported, MonooxygenaseUniRule annotation, Oxidoreductase

Keywords - Biological processi

Calvin cycleUniRule annotation, Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciBSP640510:GI28-4031-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribulose bisphosphate carboxylase large chainUniRule annotation (EC:4.1.1.39UniRule annotation)
Short name:
RuBisCO large subunitUniRule annotation
Gene namesi
Name:cbbLUniRule annotation
ORF Names:BC1001_3963Imported
OrganismiBurkholderia sp. CCGE1001Imported
Taxonomic identifieri640510 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeBurkholderia
ProteomesiUP000007095: Chromosome 2

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei217 – 2171N6-carboxylysineUniRule annotation

Interactioni

Subunit structurei

Heterohexadecamer of 8 large chains and 8 small chains.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE8YSE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuBisCO large chain family. Type I subfamily.UniRule annotation

Phylogenomic databases

KOiK01601.

Family and domain databases

Gene3Di3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPiMF_01338. RuBisCO_L_type1.
InterProiIPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view]
PfamiPF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view]
SUPFAMiSSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEiPS00157. RUBISCO_LARGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8YSE3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNDFSQPAIE SLHKPRNAGD PRERYAAGVM KYREMGYWQP DYTPKDTDVI
60 70 80 90 100
ALFRITPQPG VEPEEAAAAV AGESSTATWT VVWTDRLTAC DMYRAKAYRV
110 120 130 140 150
DPVPASNAGE PQYFAYIAYE LDLFEEGSVA NLTASIIGNV FGFKPLKALR
160 170 180 190 200
LEDMRIPVAY LKTFQGPPTG IVVERERLDK YGRPLLGATV KPKLGLSGKN
210 220 230 240 250
YGRVVYEGLR GGLDFLKDDE NINSQAFMHW RDRFLFSMEA VNRAQAETGE
260 270 280 290 300
VKGHYLNVTA GTMEDMYERA EFAKELGSCI VMIDLVIGWT AIQSMGRWAR
310 320 330 340 350
RNDMILHLHR AGHSTYTRQR NHGISFRVIA KWLRMAGVDH AHAGTAVGKL
360 370 380 390 400
EGDPLTVQGF YNVCREARNE VDLSRGLFFD QPWAGLRKVM PVASGGIHAG
410 420 430 440 450
QMHQLLELFG DDAILQFGGG TIGHPGGIQA GAVANRVALE AMVKARNEGR
460 470 480 490
DIRHEGPDIL EAAARWCGPL KQALDTWRDV TFNYASTDSP DFAATPTAA
Length:499
Mass (Da):55,261
Last modified:April 5, 2011 - v1
Checksum:i6991FC31B6094257
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002520 Genomic DNA. Translation: ADX57374.1.
RefSeqiWP_013590483.1. NC_015137.1.
YP_004230434.1. NC_015137.1.

Genome annotation databases

EnsemblBacteriaiADX57374; ADX57374; BC1001_3963.
GeneIDi10225554.
KEGGibug:BC1001_3963.
PATRICi46900954. VBIBurSp1058_4154.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002520 Genomic DNA. Translation: ADX57374.1 .
RefSeqi WP_013590483.1. NC_015137.1.
YP_004230434.1. NC_015137.1.

3D structure databases

ProteinModelPortali E8YSE3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADX57374 ; ADX57374 ; BC1001_3963 .
GeneIDi 10225554.
KEGGi bug:BC1001_3963.
PATRICi 46900954. VBIBurSp1058_4154.

Phylogenomic databases

KOi K01601.

Enzyme and pathway databases

BioCyci BSP640510:GI28-4031-MONOMER.

Family and domain databases

Gene3Di 3.20.20.110. 1 hit.
3.30.70.150. 1 hit.
HAMAPi MF_01338. RuBisCO_L_type1.
InterProi IPR020878. RuBisCo_large_chain_AS.
IPR020888. RuBisCO_lsu.
IPR000685. RuBisCO_lsu_C.
IPR017443. RuBisCO_lsu_fd_N.
IPR017444. RuBisCO_lsu_N.
[Graphical view ]
Pfami PF00016. RuBisCO_large. 1 hit.
PF02788. RuBisCO_large_N. 1 hit.
[Graphical view ]
SUPFAMi SSF51649. SSF51649. 1 hit.
SSF54966. SSF54966. 1 hit.
PROSITEi PS00157. RUBISCO_LARGE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CCGE1001Imported.

Entry informationi

Entry nameiE8YSE3_9BURK
AccessioniPrimary (citable) accession number: E8YSE3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

The basic functional RuBisCO is composed of a large chain homodimer in a "head-to-tail" conformation. In form I RuBisCO this homodimer is arranged in a barrel-like tetramer with the small subunits forming a tetrameric "cap" on each end of the "barrel".UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3