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E8YRM1 (E8YRM1_9BURK) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_00825
EC=1.13.11.6 HAMAP-Rule MF_00825
Alternative name(s):
3-hydroxyanthranilate oxygenase HAMAP-Rule MF_00825
3-hydroxyanthranilic acid dioxygenase HAMAP-Rule MF_00825
Gene names
Name:nbaC HAMAP-Rule MF_00825
ORF Names:BC1001_3829 EMBL ADX57240.1
OrganismBurkholderia sp. CCGE1001 EMBL ADX57240.1
Taxonomic identifier640510 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia

Protein attributes

Sequence length174 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_00825

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_00825

Cofactor

Binds 2 Fe2+ ions per subunit By similarity. HAMAP-Rule MF_00825

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_00825

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00825

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00825.

Sequence similarities

Belongs to the 3-HAO family. HAMAP-Rule MF_00825

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding511Iron 1; catalytic By similarity HAMAP-Rule MF_00825
Metal binding571Iron 1; catalytic By similarity HAMAP-Rule MF_00825
Metal binding951Iron 1; catalytic By similarity HAMAP-Rule MF_00825
Metal binding1251Iron 2 By similarity HAMAP-Rule MF_00825
Metal binding1281Iron 2 By similarity HAMAP-Rule MF_00825
Metal binding1621Iron 2 By similarity HAMAP-Rule MF_00825
Metal binding1651Iron 2 By similarity HAMAP-Rule MF_00825
Binding site471Dioxygen By similarity HAMAP-Rule MF_00825
Binding site571Substrate By similarity HAMAP-Rule MF_00825
Binding site991Substrate By similarity HAMAP-Rule MF_00825
Binding site1101Substrate By similarity HAMAP-Rule MF_00825

Sequences

Sequence LengthMass (Da)Tools
E8YRM1 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: BB8154A2CFD9E4D5

FASTA17420,135
        10         20         30         40         50         60 
MLKYGKPFNF QRWIDEHAHL LKPPVGNQQV WQDSDFLVTV VGGPNHRTDY HDDPVEEFFF 

        70         80         90        100        110        120 
QMRGNAYLNL WIDGKRERVD LNEGDIFLLP PHVRHSPQRP EAGSLCLVVE RQRPAGLVDG 

       130        140        150        160        170 
FEWYCDACGH LVHRVEVQLK SIVTDLPPLF DAFFASEDLR RCKNCGHLHP GHAR

« Hide

References

[1]"Complete sequence of chromosome2 of Burkholderia sp. CCGE1001."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Saunders E., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Mikhailova N., Pagani I., Martinez-Romero E. expand/collapse author list , Rogel M.A., Auchtung J., Tiedje J., Woyke T.
Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CCGE1001 EMBL ADX57240.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002520 Genomic DNA. Translation: ADX57240.1.
RefSeqYP_004230300.1. NC_015137.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADX57240; ADX57240; BC1001_3829.
GeneID10225420.
KEGGbug:BC1001_3829.
PATRIC46900671. VBIBurSp1058_4014.

Phylogenomic databases

KOK00452.

Enzyme and pathway databases

BioCycBSP640510:GI28-3897-MONOMER.
UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 1 hit.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
SUPFAMSSF51182. RmlC_like_cupin. 1 hit.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE8YRM1_9BURK
AccessionPrimary (citable) accession number: E8YRM1
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: May 29, 2013
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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