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E8YBY9

- E8YBY9_ECOKO

UniProt

E8YBY9 - E8YBY9_ECOKO

Protein

Glutamate decarboxylase

Gene

gadA

Organism
Escherichia coli (strain ATCC 55124 / KO11)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glutamate decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glutamate metabolic process Source: InterPro

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL595495:GI1Q-224-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
    Gene namesi
    Name:gadAImported
    Ordered Locus Names:EKO11_0222Imported
    ORF Names:KO11_05180Imported
    OrganismiEscherichia coli (strain ATCC 55124 / KO11)Imported
    Taxonomic identifieri595495 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000010089: Chromosome, UP000002250: Chromosome

    Structurei

    3D structure databases

    SMRiE8YBY9. Positions 4-452.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the group II decarboxylase family.UniRule annotation

    Phylogenomic databases

    KOiK01580.
    OMAiMIGRLFN.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    InterProiIPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view]
    PfamiPF00282. Pyridoxal_deC. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEiPS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8YBY9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDQKLLTDFR SELLDSRFGA KAISTIAESK RFPLHEMRDD VAFQIINDEL    50
    YLDGNARQNL ATFCQTWDDE NVHKLMDLSI NKNWIDKEEY PQSAAIDLRC 100
    VNMVADLWHA PAPKNGQAVG TNTIGSSEAC MLGGMAMKWR WRKRMEAAGK 150
    PTDKPNLVCG PVQICWHKFA RYWDVELREI PMRPGQLFMD PKRMIEACDE 200
    NTIGVVPTFG VTYTGNYEFP QPLHDALDKF QADTGIDIDM HIDAASGGFL 250
    APFVAPDIVW DFRLPRVKSI SASGHKFGLA PLGCGWVIWR DEEALPQELV 300
    FNVDYLGGQI GTFAINFSRP AGQVIAQYYE FLRLGREGYT KVQNASYQVA 350
    AYLADEIAKL GPYEFICTGR PDEGIPAVCF KLKDGEDPGY TLYDLSERLR 400
    LRGWQVPAFT LGGEATDIVV MRIMCRRGFE MDFAELLLED YKASLKYLSD 450
    HPKLQGIAQQ NSFKHT 466
    Length:466
    Mass (Da):52,685
    Last modified:April 5, 2011 - v1
    Checksum:i86F963E710553E22
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002516 Genomic DNA. Translation: ADX48884.1.
    CP002970 Genomic DNA. Translation: AFH16023.1.
    RefSeqiYP_005275948.1. NC_016902.1.
    YP_006163375.1. NC_017660.1.

    Genome annotation databases

    EnsemblBacteriaiADX48884; ADX48884; EKO11_0222.
    AFH16023; AFH16023; KO11_05180.
    GeneIDi11775258.
    12761220.
    KEGGiekf:KO11_05180.
    eko:EKO11_0222.
    PATRICi48640231. VBIEscCol13896_0222.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002516 Genomic DNA. Translation: ADX48884.1 .
    CP002970 Genomic DNA. Translation: AFH16023.1 .
    RefSeqi YP_005275948.1. NC_016902.1.
    YP_006163375.1. NC_017660.1.

    3D structure databases

    SMRi E8YBY9. Positions 4-452.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADX48884 ; ADX48884 ; EKO11_0222 .
    AFH16023 ; AFH16023 ; KO11_05180 .
    GeneIDi 11775258.
    12761220.
    KEGGi ekf:KO11_05180.
    eko:EKO11_0222.
    PATRICi 48640231. VBIEscCol13896_0222.

    Phylogenomic databases

    KOi K01580.
    OMAi MIGRLFN.

    Enzyme and pathway databases

    BioCyci ECOL595495:GI1Q-224-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    InterProi IPR010107. Glutamate_decarboxylase.
    IPR002129. PyrdxlP-dep_de-COase.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR021115. Pyridoxal-P_BS.
    [Graphical view ]
    Pfami PF00282. Pyridoxal_deC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
    PROSITEi PS00392. DDC_GAD_HDC_YDC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Escherichia coli KO11."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Keating D., Landick R., Woyke T.
      Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 55124 / KO11Imported and KO11Imported.
    2. "Optical mapping and sequencing of the Escherichia coli KO11 genome reveal extensive chromosomal rearrangements, and multiple tandem copies of the Zymomonas mobilis pdc and adhB genes."
      Turner P.C., Yomano L.P., Jarboe L.R., York S.W., Baggett C.L., Moritz B.E., Zentz E.B., Shanmugam K.T., Ingram L.O.
      J. Ind. Microbiol. Biotechnol. 39:629-639(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KO11FLImported.

    Entry informationi

    Entry nameiE8YBY9_ECOKO
    AccessioniPrimary (citable) accession number: E8YBY9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3