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E8Y5E4

- E8Y5E4_ECOKO

UniProt

E8Y5E4 - E8Y5E4_ECOKO

Protein

Aldose 1-epimerase

Gene

galM

Organism
Escherichia coli (strain ATCC 55124 / KO11)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    Converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.UniRule annotation

    Catalytic activityi

    Alpha-D-glucose = beta-D-glucose.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. aldose 1-epimerase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. galactose metabolic process Source: InterPro

    Keywords - Molecular functioni

    IsomeraseUniRule annotationImported

    Keywords - Biological processi

    Carbohydrate metabolismUniRule annotation

    Enzyme and pathway databases

    BioCyciECOL595495:GI1Q-3180-MONOMER.
    UniPathwayiUPA00242.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldose 1-epimeraseUniRule annotation (EC:5.1.3.3UniRule annotation)
    Alternative name(s):
    Galactose mutarotaseUniRule annotation
    Gene namesi
    Name:galMImported
    Ordered Locus Names:EKO11_3130Imported
    ORF Names:KO11_20000Imported
    OrganismiEscherichia coli (strain ATCC 55124 / KO11)Imported
    Taxonomic identifieri595495 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
    ProteomesiUP000010089: Chromosome, UP000002250: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldose epimerase family.UniRule annotation

    Phylogenomic databases

    KOiK01785.
    OMAiCPISLTQ.

    Family and domain databases

    Gene3Di2.70.98.10. 1 hit.
    InterProiIPR018052. Ald1_epimerase_CS.
    IPR013458. Ald_epimerase_bac.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view]
    PfamiPF01263. Aldose_epim. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005096. GALM. 1 hit.
    SUPFAMiSSF74650. SSF74650. 1 hit.
    TIGRFAMsiTIGR02636. galM_Leloir. 1 hit.
    PROSITEiPS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8Y5E4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLNETPALAP DGQPYRLLTL RNNAGMVVTL MDWGATLLSA RIPLSDGSVR    50
    EALLGCASPE CYQDQAAFLG ASIGRYANRI ANSRYTFDGE TVTLSPSQGV 100
    NQLHGGPEGF DKRRWQIVNQ NDRQVLFALS SDDGDQGFPG NLGATVQYRL 150
    TDDNRISITY RATVDKPCPV NMTNHVYFNL DGEQSDVRNH KLQILADEYL 200
    PVDEGGIPHD GLKSVAGTSF DFRSAKIIAS EFLADDDQRK VKGYDHAFLL 250
    QAKGDGKKVA AHVWSADEKL QLKVYTTAPA LQFYSGNFLG GTPSRGTEPY 300
    ADWQGLALES EFLPDSPNHP EWPQPDCFLR PGEEYSSLTE YQFIAE 346
    Length:346
    Mass (Da):38,190
    Last modified:April 5, 2011 - v1
    Checksum:i4373732BAEA83E1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002516 Genomic DNA. Translation: ADX51716.1.
    CP002970 Genomic DNA. Translation: AFH18966.1.
    RefSeqiYP_005278780.1. NC_016902.1.
    YP_006166318.1. NC_017660.1.

    Genome annotation databases

    EnsemblBacteriaiADX51716; ADX51716; EKO11_3130.
    AFH18966; AFH18966; KO11_20000.
    GeneIDi11779639.
    12760331.
    KEGGiekf:KO11_20000.
    eko:EKO11_3130.
    PATRICi48646283. VBIEscCol13896_3168.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002516 Genomic DNA. Translation: ADX51716.1 .
    CP002970 Genomic DNA. Translation: AFH18966.1 .
    RefSeqi YP_005278780.1. NC_016902.1.
    YP_006166318.1. NC_017660.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADX51716 ; ADX51716 ; EKO11_3130 .
    AFH18966 ; AFH18966 ; KO11_20000 .
    GeneIDi 11779639.
    12760331.
    KEGGi ekf:KO11_20000.
    eko:EKO11_3130.
    PATRICi 48646283. VBIEscCol13896_3168.

    Phylogenomic databases

    KOi K01785.
    OMAi CPISLTQ.

    Enzyme and pathway databases

    UniPathwayi UPA00242 .
    BioCyci ECOL595495:GI1Q-3180-MONOMER.

    Family and domain databases

    Gene3Di 2.70.98.10. 1 hit.
    InterProi IPR018052. Ald1_epimerase_CS.
    IPR013458. Ald_epimerase_bac.
    IPR015443. Aldose_1-epimerase.
    IPR008183. Aldose_1/G6P_1-epimerase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    [Graphical view ]
    Pfami PF01263. Aldose_epim. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005096. GALM. 1 hit.
    SUPFAMi SSF74650. SSF74650. 1 hit.
    TIGRFAMsi TIGR02636. galM_Leloir. 1 hit.
    PROSITEi PS00545. ALDOSE_1_EPIMERASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Escherichia coli KO11."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Munk A.C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Keating D., Landick R., Woyke T.
      Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 55124 / KO11Imported and KO11Imported.
    2. "Optical mapping and sequencing of the Escherichia coli KO11 genome reveal extensive chromosomal rearrangements, and multiple tandem copies of the Zymomonas mobilis pdc and adhB genes."
      Turner P.C., Yomano L.P., Jarboe L.R., York S.W., Baggett C.L., Moritz B.E., Zentz E.B., Shanmugam K.T., Ingram L.O.
      J. Ind. Microbiol. Biotechnol. 39:629-639(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: KO11FLImported.

    Entry informationi

    Entry nameiE8Y5E4_ECOKO
    AccessioniPrimary (citable) accession number: E8Y5E4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3