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Protein

Alanine racemase

Gene

AciX9_3728

Organism
Granulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (AciX9_3728)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei32Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei128SubstrateUniRule annotation1
Active sitei276Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei325Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGTUN1198114:G12UY-3690-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:AciX9_3728Imported
OrganismiGranulicella tundricola (strain ATCC BAA-1859 / DSM 23138 / MP5ACTX9)Imported
Taxonomic identifieri1198114 [NCBI]
Taxonomic lineageiBacteriaAcidobacteriaAcidobacterialesAcidobacteriaceaeGranulicella
Proteomesi
  • UP000000343 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei32N6-(pyridoxal phosphate)lysineUniRule annotation1

Structurei

3D structure databases

ProteinModelPortaliE8WVX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini255 – 373Ala_racemase_CInterPro annotationAdd BLAST119

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWEILCGF.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

E8WVX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNWTEIDAA ALTANYKAIQ RVAGAEVLAV IKARAYGHGA ERCAPILVRA
60 70 80 90 100
GARWLGVTCA SEGQQVRAAL DHAGLEADIL VMSGSLPKDV PAIVSAHLIP
110 120 130 140 150
VIWTTDHIDL LAGIGCRVHV EVDTGMGRQG VRPGQDLATL LARISAAGLR
160 170 180 190 200
LDGLFTHFCS SEVANSNLTL RQRALFEAAV QQTVTAGLTP AWLHAANSSA
210 220 230 240 250
VDNETPEPSS GDWLTTLAAA AGSQTMVRTG LALYGYCLPI EGGALHHLSP
260 270 280 290 300
ALQPVLTWKA RILAVRDLAP GDTVGYNATF IAGPAMKVAL LPVGYADGLR
310 320 330 340 350
RELSHPHGWV MVQGHPAPIL GRISMNLTVV DVTAIPAASA GDEATLLGPG
360 370
ITAEDHARLA RTISYEILCG IHPCG
Length:375
Mass (Da):39,265
Last modified:April 5, 2011 - v1
Checksum:iFBEE7E5E8A758D85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002480 Genomic DNA. Translation: ADW70729.1.
RefSeqiWP_013582038.1. NC_015064.1.

Genome annotation databases

EnsemblBacteriaiADW70729; ADW70729; AciX9_3728.
KEGGiacm:AciX9_3728.

Similar proteinsi

Entry informationi

Entry nameiE8WVX0_GRATM
AccessioniPrimary (citable) accession number: E8WVX0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: September 27, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported