Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

E8WSF9 (E8WSF9_GEOS8) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:GM18_3884 EMBL ADW15306.1
OrganismGeobacter sp. (strain M18) [Complete proteome] [HAMAP] EMBL ADW15306.1
Taxonomic identifier443143 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain107 – 299193ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding134 – 18552ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2531Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2661Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2681Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
E8WSF9 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 4D2BCE3F5C34FF57

FASTA30532,862
        10         20         30         40         50         60 
MTVDELKTKK IAVLMGGLSA EREVSLNSGK AVLASLVRQG YQAVGIDVGR DLPQRLAEEQ 

        70         80         90        100        110        120 
VERAFIALHG RFGEDGSVQG LLELMAIPYT GSGVLASALA IDKIAAKTMF AAAGLKLAPY 

       130        140        150        160        170        180 
QVLSRGEELK LANPLPVVVK PSREGSSVGV SIVREPQQME KALAEAFRYD SEILIEAFID 

       190        200        210        220        230        240 
GKEVQVGILD GRAMGAIEIV PKNEFYDYEA KYTDGGAEHI LPARLPEQVY QAVLKEGEKA 

       250        260        270        280        290        300 
HAALGCDCYS RVDFLVNEAG ECYLLEVNTL PGMTDLSLLP EIARGSGIDF DQLVQRILLA 


ASLKI 

« Hide

References

[1]"Complete sequence of Geobacter sp. M18."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Chertkov O., Munk C., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Holmes D. expand/collapse author list , Aklujkar M., Lovley D., Woyke T.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: M18 EMBL ADW15306.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002479 Genomic DNA. Translation: ADW15306.1.
RefSeqYP_004200582.1. NC_014973.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADW15306; ADW15306; GM18_3884.
GeneID10199515.
KEGGgeb:GM18_3884.
PATRIC46951705. VBIGeoSp68312_3847.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011592.
KOK01921.
OMADTQYRIP.

Enzyme and pathway databases

BioCycGSP443143:GHZL-3956-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8WSF9_GEOS8
AccessionPrimary (citable) accession number: E8WSF9
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 19, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)