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Protein
Submitted name:

2-isopropylmalate synthase/homocitrate synthase family protein

Gene

GM18_1123

Organism
Geobacter sp. (strain M18)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. 2-isopropylmalate synthase activity Source: InterPro

GO - Biological processi

  1. leucine biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisSAAS annotation

Enzyme and pathway databases

BioCyciGSP443143:GHZL-1154-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
2-isopropylmalate synthase/homocitrate synthase family proteinImported (EC:2.3.1.182Imported)
Gene namesi
Ordered Locus Names:GM18_1123Imported
OrganismiGeobacter sp. (strain M18)Imported
Taxonomic identifieri443143 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfuromonadalesGeobacteraceaeGeobacter
ProteomesiUP000001442: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE8WM84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alpha-IPM synthase/homocitrate synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000046860.
KOiK01649.
OMAiTIFGKTW.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005675. LeuA-rel.
IPR000891. PYR_CT.
[Graphical view]
PANTHERiPTHR10277:SF5. PTHR10277:SF5. 1 hit.
PfamiPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTiSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF110921. SSF110921. 1 hit.
TIGRFAMsiTIGR00977. LeuA_rel. 1 hit.
PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8WM84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLVKLYDTT LRDGTQAEDI SFLVEDKIRI AHKLDECGIH YIEGGWPGSN
60 70 80 90 100
PKDVAFFKDI KKEKLSQAKI AAFGSTRRAK ITPDKDQNLR TLVDSKADAA
110 120 130 140 150
TIFGKSWDFQ VHEALRIPLE ENLEMIFDSL EYLKGHMPEV FYDAEHFFDG
160 170 180 190 200
YKSNPEYAIK TLQAAQQAGA DCIILCDTNG GSMPYEIARI VNEVKKSITT
210 220 230 240 250
PLGVHAHNDG ECAVANTIIS VEQGIVHVQG TINGFGERCG NANLCSIIPA
260 270 280 290 300
LKVKMKRDCI SDAQMRTLRE LSRYVYELAN LAPNKHQPYV GNSAFAHKGG
310 320 330 340 350
VHVSAIQRHP ETYEHMRPEL VGNTTRVLVS DLSGRANILA KATEFNINLD
360 370 380 390 400
SKDPVTLEIL EDIKSMENRG YQFEGAEASF ELLMKRALGT HRKFFSVIGF
410 420 430 440 450
RVIDEKRSED DQPISEATIK VKVGGKIEHT ASEGHGPVNA LDNALRKALE
460 470 480 490 500
KFYPRLKDVK LHDYKVRVLP AGQGTASSIR VLIESGDKEG RWGTVGVSSN
510 520
VIEASYQALV DAIEFKLHKD EETAAPKK
Length:528
Mass (Da):58,642
Last modified:April 5, 2011 - v1
Checksum:iDCC80117B9F71451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002479 Genomic DNA. Translation: ADW12598.1.
RefSeqiWP_015719458.1. NC_014973.1.
YP_004197874.1. NC_014973.1.

Genome annotation databases

EnsemblBacteriaiADW12598; ADW12598; GM18_1123.
GeneIDi10196714.
KEGGigeb:GM18_1123.
PATRICi46946144. VBIGeoSp68312_1119.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002479 Genomic DNA. Translation: ADW12598.1.
RefSeqiWP_015719458.1. NC_014973.1.
YP_004197874.1. NC_014973.1.

3D structure databases

ProteinModelPortaliE8WM84.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADW12598; ADW12598; GM18_1123.
GeneIDi10196714.
KEGGigeb:GM18_1123.
PATRICi46946144. VBIGeoSp68312_1119.

Phylogenomic databases

HOGENOMiHOG000046860.
KOiK01649.
OMAiTIFGKTW.

Enzyme and pathway databases

BioCyciGSP443143:GHZL-1154-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013709. 2-isopropylmalate_synth_dimer.
IPR002034. AIPM/Hcit_synth_CS.
IPR013785. Aldolase_TIM.
IPR005675. LeuA-rel.
IPR000891. PYR_CT.
[Graphical view]
PANTHERiPTHR10277:SF5. PTHR10277:SF5. 1 hit.
PfamiPF00682. HMGL-like. 1 hit.
PF08502. LeuA_dimer. 1 hit.
[Graphical view]
SMARTiSM00917. LeuA_dimer. 1 hit.
[Graphical view]
SUPFAMiSSF110921. SSF110921. 1 hit.
TIGRFAMsiTIGR00977. LeuA_rel. 1 hit.
PROSITEiPS00815. AIPM_HOMOCIT_SYNTH_1. 1 hit.
PS50991. PYR_CT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: M18Imported.

Entry informationi

Entry nameiE8WM84_GEOS8
AccessioniPrimary (citable) accession number: E8WM84
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.