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Protein

Glutamate decarboxylase

Gene

Sfla_3455

Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciSFLA591167:GI5Y-3501-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylaseUniRule annotation (EC:4.1.1.15UniRule annotation)
Gene namesi
Ordered Locus Names:Sfla_3455Imported
OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
Taxonomic identifieri591167 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000002066 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE8WG52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

KOiK01580.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

E8WG52-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALHQGRHGR PAPSEEHRRL ALNPFFGEAD PTAPMVAAPP THRLPEDPLP
60 70 80 90 100
PSTAYRLVHD ELMLDGNSRL NLATFVTTWM EPQAGVLMSE CRDKNMIDKD
110 120 130 140 150
EYPRTAELER RCVAMLADLW NAPDPASTVG CSTTGSSEAC MLAGMALKRR
160 170 180 190 200
WSARNADRYP ATARPNLVMG VNVQVCWEKF CTFWEVEPRQ VPMDGERFHL
210 220 230 240 250
DPQAAAELCD ENTIGVVGIL GSTFDGSYEP IADLCAALDD LQERTGLDIP
260 270 280 290 300
VHVDGASGAM IAPFLDPDLV WDFRLPRVSS INTSGHKYGL VYPGVGWALW
310 320 330 340 350
RSQAELPEEL VFRVNYLGGD MPTFALNFSR PGAQVVAQYY TFLRLGREGY
360 370 380 390 400
RAVQQASRDI ARRLAVQFEA LEDFRLLTRG DELPVFAVTT KPDVQAYDVF
410 420 430 440 450
DVSRRLRERG WLVPAYTFPA NRQDLSVLRV VCRNGFSSDL AELLLDDLRG
460 470
LLPELRSQAH PLHRDPGVQT AFHH
Length:474
Mass (Da):52,985
Last modified:April 4, 2011 - v1
Checksum:i3F72C8988DC79935
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW04875.1.
RefSeqiYP_004924392.1. NC_016114.1.

Genome annotation databases

EnsemblBacteriaiADW04875; ADW04875; Sfla_3455.
KEGGisfa:Sfla_3455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW04875.1.
RefSeqiYP_004924392.1. NC_016114.1.

3D structure databases

ProteinModelPortaliE8WG52.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADW04875; ADW04875; Sfla_3455.
KEGGisfa:Sfla_3455.

Phylogenomic databases

KOiK01580.

Enzyme and pathway databases

BioCyciSFLA591167:GI5Y-3501-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33331 / DSM 40990 / IAF-45CDImported.

Entry informationi

Entry nameiE8WG52_STRFA
AccessioniPrimary (citable) accession number: E8WG52
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2011
Last sequence update: April 4, 2011
Last modified: March 31, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.