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E8WFP2

- E8WFP2_STRFA

UniProt

E8WFP2 - E8WFP2_STRFA

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Protein

Malate synthase

Gene
Sfla_1036
Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691Proton acceptor By similarityUniRule annotation
Active sitei453 – 4531Proton donor By similarityUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

BioCyciSFLA591167:GI5Y-1040-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthaseUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Ordered Locus Names:Sfla_1036Imported
OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
Taxonomic identifieri591167 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000002066: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE8WFP2.

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.UniRule annotation

Phylogenomic databases

KOiK01638.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8WFP2-1 [UniParc]FASTAAdd to Basket

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MSAPAPSPLA IVDAEPLPRQ DEVLTDAALA FVAELHRRFT PRRDELLARR    50
GERRAEIART STLDFLPETE AVRVDDTWKV APAPAALDDR RVEITGPTDR 100
KMTVNALNSG ARVWLADFED ASAPTWENVV TGQLNLIDAY TRNIDFTDPR 150
SGKSYALKPA EELATVVTRP RGWHLDERHL QLDGTPVPGA LVDFGLYFFH 200
NAQRLIDLGK GPYFYLPKTE SYLEARLWND IFVFAQDYVG IPQGTVRATV 250
LIETITAAYE MEEILYELRD HASGLNAGRW DYLFSIVKNF RDGGSKFVLP 300
DRNLVTMTAP FMRAYTELLV RTCHKRGAHA IGGMAAFIPS RRDAEVNKVA 350
FEKVKADKDR EAGDGFDGSW VAHPDLVPIA MASFDAVLGA KPNQKDRLRE 400
DVSVAAGDLI AIDTLDAKPS YDGLRNAVAV GIRYIEAWLR GMGAVAIFNL 450
MEDAATAEIS RSQIWQWINA DVVFENGEHA TSDLARKVAA EELAAIRAEV 500
GDETFEAGKW QQAHDLLLQV SLDQDYADFL TLPAYEQLG 539
Length:539
Mass (Da):59,891
Last modified:April 5, 2011 - v1
Checksum:iDACA73566F71A31F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002475 Genomic DNA. Translation: ADW02490.1.
RefSeqiYP_004922007.1. NC_016114.1.

Genome annotation databases

EnsemblBacteriaiADW02490; ADW02490; Sfla_1036.
GeneIDi11372123.
KEGGisfa:Sfla_1036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002475 Genomic DNA. Translation: ADW02490.1 .
RefSeqi YP_004922007.1. NC_016114.1.

3D structure databases

ProteinModelPortali E8WFP2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADW02490 ; ADW02490 ; Sfla_1036 .
GeneIDi 11372123.
KEGGi sfa:Sfla_1036.

Phylogenomic databases

KOi K01638.

Enzyme and pathway databases

UniPathwayi UPA00703 ; UER00720 .
BioCyci SFLA591167:GI5Y-1040-MONOMER.

Family and domain databases

InterProi IPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view ]
Pfami PF01274. Malate_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001363. Malate_synth. 1 hit.
SUPFAMi SSF51645. SSF51645. 1 hit.
TIGRFAMsi TIGR01344. malate_syn_A. 1 hit.
PROSITEi PS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33331 / DSM 40990 / IAF-45CD.

Entry informationi

Entry nameiE8WFP2_STRFA
AccessioniPrimary (citable) accession number: E8WFP2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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