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Protein

Malate synthase

Gene

Sfla_1036

Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei169 – 1691Proton acceptorUniRule annotation
Active sitei453 – 4531Proton donorUniRule annotation

GO - Molecular functioni

  1. malate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseImported, Transferase

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

BioCyciSFLA591167:GI5Y-1040-MONOMER.
UniPathwayiUPA00703; UER00720.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate synthaseUniRule annotation (EC:2.3.3.9UniRule annotation)
Gene namesi
Ordered Locus Names:Sfla_1036Imported
OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
Taxonomic identifieri591167 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000002066: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE8WFP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the malate synthase family.UniRule annotation

Phylogenomic databases

KOiK01638.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8WFP2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAPAPSPLA IVDAEPLPRQ DEVLTDAALA FVAELHRRFT PRRDELLARR
60 70 80 90 100
GERRAEIART STLDFLPETE AVRVDDTWKV APAPAALDDR RVEITGPTDR
110 120 130 140 150
KMTVNALNSG ARVWLADFED ASAPTWENVV TGQLNLIDAY TRNIDFTDPR
160 170 180 190 200
SGKSYALKPA EELATVVTRP RGWHLDERHL QLDGTPVPGA LVDFGLYFFH
210 220 230 240 250
NAQRLIDLGK GPYFYLPKTE SYLEARLWND IFVFAQDYVG IPQGTVRATV
260 270 280 290 300
LIETITAAYE MEEILYELRD HASGLNAGRW DYLFSIVKNF RDGGSKFVLP
310 320 330 340 350
DRNLVTMTAP FMRAYTELLV RTCHKRGAHA IGGMAAFIPS RRDAEVNKVA
360 370 380 390 400
FEKVKADKDR EAGDGFDGSW VAHPDLVPIA MASFDAVLGA KPNQKDRLRE
410 420 430 440 450
DVSVAAGDLI AIDTLDAKPS YDGLRNAVAV GIRYIEAWLR GMGAVAIFNL
460 470 480 490 500
MEDAATAEIS RSQIWQWINA DVVFENGEHA TSDLARKVAA EELAAIRAEV
510 520 530
GDETFEAGKW QQAHDLLLQV SLDQDYADFL TLPAYEQLG
Length:539
Mass (Da):59,891
Last modified:April 5, 2011 - v1
Checksum:iDACA73566F71A31F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW02490.1.
RefSeqiYP_004922007.1. NC_016114.1.

Genome annotation databases

EnsemblBacteriaiADW02490; ADW02490; Sfla_1036.
GeneIDi11372123.
KEGGisfa:Sfla_1036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW02490.1.
RefSeqiYP_004922007.1. NC_016114.1.

3D structure databases

ProteinModelPortaliE8WFP2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADW02490; ADW02490; Sfla_1036.
GeneIDi11372123.
KEGGisfa:Sfla_1036.

Phylogenomic databases

KOiK01638.

Enzyme and pathway databases

UniPathwayiUPA00703; UER00720.
BioCyciSFLA591167:GI5Y-1040-MONOMER.

Family and domain databases

InterProiIPR011076. Malate_synth-like.
IPR006252. Malate_synthA.
IPR001465. Malate_synthase.
IPR019830. Malate_synthase_CS.
[Graphical view]
PfamiPF01274. Malate_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF001363. Malate_synth. 1 hit.
SUPFAMiSSF51645. SSF51645. 1 hit.
TIGRFAMsiTIGR01344. malate_syn_A. 1 hit.
PROSITEiPS00510. MALATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33331 / DSM 40990 / IAF-45CDImported.

Entry informationi

Entry nameiE8WFP2_STRFA
AccessioniPrimary (citable) accession number: E8WFP2
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: February 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.