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E8WDE5

- E8WDE5_STRFA

UniProt

E8WDE5 - E8WDE5_STRFA

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Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei208 – 2081ATPUniRule annotation
Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
Binding sitei215 – 2151ATPUniRule annotation
Binding sitei230 – 2301ATPUniRule annotation
Binding sitei259 – 2591ATPUniRule annotation
Binding sitei299 – 2991ATPUniRule annotation
Binding sitei377 – 3771ATPUniRule annotation
Binding sitei383 – 3831ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSFLA591167:GI5Y-5730-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Sfla_5642Imported
OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
Taxonomic identifieri591167 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000002066: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8WDE5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLLARIALVS LEVAATSART RKTALLAALF RDAEPDDVPV VIPYLAGRLP
60 70 80 90 100
QGRLGIGWST LRVPVTPAGE PTLTVAGTDA ELSAIGALGG PGSQAARKER
110 120 130 140 150
LTRLLGAATA QEQHFLRGLL TGEVRQGALD AVAVDALADA AGAPRDEVRR
160 170 180 190 200
AVMLAGSLGP VARTLLAEGP GALASFRLTV GRPVQPMLAH TSRSVTEAID
210 220 230 240 250
RLGPCVVEEK LDGIRVQVHR DGPQVRVYTR ALDDITDRLP EVAAAVTRLR
260 270 280 290 300
AERFILDGEA IALGADGRPR PFQETAGRVG SRRDVATAAG AVPVVPVFFD
310 320 330 340 350
VLSVDGRDLL DLPLSERHRD LASLVPEEMR VRRVAVEYPA DERRRAAAVA
360 370 380 390 400
FSEDTLARGH EGVVVKGTAA PYSAGRRGAS WLKVKPVHTL DLVVLAAEWG
410 420 430 440 450
HGRRTGRLSN LHLGARRDDG TFAMLGKTFK GLTDTMLSWQ TQRLRELATG
460 470 480 490 500
DDGHVVTVRP ELVVEIAYDG LQSSTRYPEG VTLRFARVLR YREDKSAEEA
510
DTVGTVLSRR G
Length:511
Mass (Da):54,804
Last modified:April 5, 2011 - v1
Checksum:i7847AD1DEF20A351
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW07037.1.
RefSeqiYP_004926554.1. NC_016114.1.

Genome annotation databases

EnsemblBacteriaiADW07037; ADW07037; Sfla_5642.
GeneIDi11371055.
KEGGisfa:Sfla_5642.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW07037.1 .
RefSeqi YP_004926554.1. NC_016114.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADW07037 ; ADW07037 ; Sfla_5642 .
GeneIDi 11371055.
KEGGi sfa:Sfla_5642.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci SFLA591167:GI5Y-5730-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33331 / DSM 40990 / IAF-45CDImported.

Entry informationi

Entry nameiE8WDE5_STRFA
AccessioniPrimary (citable) accession number: E8WDE5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3