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E8WDE5

- E8WDE5_STRFA

UniProt

E8WDE5 - E8WDE5_STRFA

Protein

Probable DNA ligase

Gene

lig

Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei208 – 2081ATPUniRule annotation
    Active sitei210 – 2101N6-AMP-lysine intermediateUniRule annotation
    Binding sitei215 – 2151ATPUniRule annotation
    Binding sitei230 – 2301ATPUniRule annotation
    Binding sitei259 – 2591ATPUniRule annotation
    Binding sitei299 – 2991ATPUniRule annotation
    Binding sitei377 – 3771ATPUniRule annotation
    Binding sitei383 – 3831ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFLA591167:GI5Y-5730-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Sfla_5642Imported
    OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
    Taxonomic identifieri591167 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000002066: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK01971.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8WDE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLARIALVS LEVAATSART RKTALLAALF RDAEPDDVPV VIPYLAGRLP    50
    QGRLGIGWST LRVPVTPAGE PTLTVAGTDA ELSAIGALGG PGSQAARKER 100
    LTRLLGAATA QEQHFLRGLL TGEVRQGALD AVAVDALADA AGAPRDEVRR 150
    AVMLAGSLGP VARTLLAEGP GALASFRLTV GRPVQPMLAH TSRSVTEAID 200
    RLGPCVVEEK LDGIRVQVHR DGPQVRVYTR ALDDITDRLP EVAAAVTRLR 250
    AERFILDGEA IALGADGRPR PFQETAGRVG SRRDVATAAG AVPVVPVFFD 300
    VLSVDGRDLL DLPLSERHRD LASLVPEEMR VRRVAVEYPA DERRRAAAVA 350
    FSEDTLARGH EGVVVKGTAA PYSAGRRGAS WLKVKPVHTL DLVVLAAEWG 400
    HGRRTGRLSN LHLGARRDDG TFAMLGKTFK GLTDTMLSWQ TQRLRELATG 450
    DDGHVVTVRP ELVVEIAYDG LQSSTRYPEG VTLRFARVLR YREDKSAEEA 500
    DTVGTVLSRR G 511
    Length:511
    Mass (Da):54,804
    Last modified:April 5, 2011 - v1
    Checksum:i7847AD1DEF20A351
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002475 Genomic DNA. Translation: ADW07037.1.
    RefSeqiYP_004926554.1. NC_016114.1.

    Genome annotation databases

    EnsemblBacteriaiADW07037; ADW07037; Sfla_5642.
    GeneIDi11371055.
    KEGGisfa:Sfla_5642.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002475 Genomic DNA. Translation: ADW07037.1 .
    RefSeqi YP_004926554.1. NC_016114.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADW07037 ; ADW07037 ; Sfla_5642 .
    GeneIDi 11371055.
    KEGGi sfa:Sfla_5642.

    Phylogenomic databases

    KOi K01971.

    Enzyme and pathway databases

    BioCyci SFLA591167:GI5Y-5730-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33331 / DSM 40990 / IAF-45CDImported.

    Entry informationi

    Entry nameiE8WDE5_STRFA
    AccessioniPrimary (citable) accession number: E8WDE5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3