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Protein

Beta-galactosidase

Gene

Sfla_4952

Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei118SubstrateUniRule annotation1
Metal bindingi122ZincUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Active sitei157Proton donorUniRule annotation1
Metal bindingi165ZincUniRule annotation1
Metal bindingi167ZincUniRule annotation1
Metal bindingi170ZincUniRule annotation1
Active sitei316NucleophileUniRule annotation1
Binding sitei324SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSPRA591167:G12Y5-4942-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Gene namesi
Ordered Locus Names:Sfla_4952Imported
OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
Taxonomic identifieri591167 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces
Proteomesi
  • UP000002066 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi591167.Sfla_4952.

Structurei

3D structure databases

ProteinModelPortaliE8W331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 390Glyco_hydro_42InterPro annotationAdd BLAST370
Domaini404 – 613Glyco_hydro_42MInterPro annotationAdd BLAST210
Domaini622 – 679Glyco_hydro_42CInterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the glycosyl hydrolase 42 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4C. Bacteria.
COG1874. LUCA.
KOiK12308.
OMAiRYEFGSR.
OrthoDBiPOG091H0719.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

E8W331-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPHSESAPYP VGLHKLAFGG DYNPEQWPEE VWHEDVRLMR EAGVTMVSVG
60 70 80 90 100
IFSWALLEPE PGTYDFGWLD RLLDLLHVNG IRADLGTPTV VPPAWFYRAH
110 120 130 140 150
PEALPVSRDG VRYAFGSRGA ICHSSAPYRA AAADITEQLA RRYGNHPALA
160 170 180 190 200
MWHVHNEYGV PVSACYCDSC AAHFRRWLAA RHGSADAVNA AWGTAFWGQR
210 220 230 240 250
YRSLEDIDPP RTTPTVGNPA QQLDYARFAD ATMRENFTAE RDILHRLAPG
260 270 280 290 300
IPVTTNFMTA LSQCESVDYW AWGREVDIVS NDHYLITDGR RTHVNLAMAA
310 320 330 340 350
DLTRSVAGGA PWLLLEHSTS GVNWQPRNPA KRPGEMARNS LAHVARGSEG
360 370 380 390 400
AMFFQWRQSR RGAEKFHSAM VPHAGTDSRI WREVSALGAG LGLLEGIRGT
410 420 430 440 450
RTVADVAMIW DWQSWWAQGL EWRPSEEHDA RERADTFYAS LFDRHLTVDF
460 470 480 490 500
AHPDADLSGY PLVVVPALYL ATEETGRNLR RYVEQGGTLV VSYFSGIVDA
510 520 530 540 550
DDAVHPGAYP GALRDVLGLT VEEFSPLGEG GTVRLITPEG APEGPELTGD
560 570 580 590 600
LWSDVVIPRG AETVWSYADG IPAGRPAVTR NRLGEGTAWY LSTRLSGPDL
610 620 630 640 650
DAVLDRAAAD ARIEPRTSLP YDVEVVRRTG DSGSYLFVIN HTDAEAVVAL
660 670 680
DTPGTELLTG EPAVDKLAVP AGAVRVVRLD G
Length:681
Mass (Da):74,827
Last modified:April 5, 2011 - v1
Checksum:iA9C3C0E8F32B7364
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW06353.1.
RefSeqiWP_014156963.1. NC_016114.1.

Genome annotation databases

EnsemblBacteriaiADW06353; ADW06353; Sfla_4952.
GeneIDi11368625.
KEGGisfa:Sfla_4952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002475 Genomic DNA. Translation: ADW06353.1.
RefSeqiWP_014156963.1. NC_016114.1.

3D structure databases

ProteinModelPortaliE8W331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi591167.Sfla_4952.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADW06353; ADW06353; Sfla_4952.
GeneIDi11368625.
KEGGisfa:Sfla_4952.

Phylogenomic databases

eggNOGiENOG4105C4C. Bacteria.
COG1874. LUCA.
KOiK12308.
OMAiRYEFGSR.
OrthoDBiPOG091H0719.

Enzyme and pathway databases

BioCyciSPRA591167:G12Y5-4942-MONOMER.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE8W331_STRFA
AccessioniPrimary (citable) accession number: E8W331
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: November 30, 2016
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.