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E8W331

- E8W331_STRFA

UniProt

E8W331 - E8W331_STRFA

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Protein

Beta-galactosidase

Gene

Sfla_4952

Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei118 – 1181Substrate
Metal bindingi122 – 1221ZincUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Active sitei157 – 1571Proton donorUniRule annotation
Metal bindingi165 – 1651ZincUniRule annotation
Metal bindingi167 – 1671ZincUniRule annotation
Metal bindingi170 – 1701ZincUniRule annotation
Active sitei316 – 3161NucleophileUniRule annotation
Binding sitei324 – 3241Substrate

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. galactose metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationImported, Hydrolase

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciSFLA591167:GI5Y-5026-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Gene namesi
Ordered Locus Names:Sfla_4952Imported
OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
Taxonomic identifieri591167 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000002066: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliE8W331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 42 family.UniRule annotation

Phylogenomic databases

KOiK12308.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProiIPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view]
PIRSFiPIRSF001084. B-galactosidase. 1 hit.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.

Sequencei

Sequence statusi: Complete.

E8W331-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHSESAPYP VGLHKLAFGG DYNPEQWPEE VWHEDVRLMR EAGVTMVSVG
60 70 80 90 100
IFSWALLEPE PGTYDFGWLD RLLDLLHVNG IRADLGTPTV VPPAWFYRAH
110 120 130 140 150
PEALPVSRDG VRYAFGSRGA ICHSSAPYRA AAADITEQLA RRYGNHPALA
160 170 180 190 200
MWHVHNEYGV PVSACYCDSC AAHFRRWLAA RHGSADAVNA AWGTAFWGQR
210 220 230 240 250
YRSLEDIDPP RTTPTVGNPA QQLDYARFAD ATMRENFTAE RDILHRLAPG
260 270 280 290 300
IPVTTNFMTA LSQCESVDYW AWGREVDIVS NDHYLITDGR RTHVNLAMAA
310 320 330 340 350
DLTRSVAGGA PWLLLEHSTS GVNWQPRNPA KRPGEMARNS LAHVARGSEG
360 370 380 390 400
AMFFQWRQSR RGAEKFHSAM VPHAGTDSRI WREVSALGAG LGLLEGIRGT
410 420 430 440 450
RTVADVAMIW DWQSWWAQGL EWRPSEEHDA RERADTFYAS LFDRHLTVDF
460 470 480 490 500
AHPDADLSGY PLVVVPALYL ATEETGRNLR RYVEQGGTLV VSYFSGIVDA
510 520 530 540 550
DDAVHPGAYP GALRDVLGLT VEEFSPLGEG GTVRLITPEG APEGPELTGD
560 570 580 590 600
LWSDVVIPRG AETVWSYADG IPAGRPAVTR NRLGEGTAWY LSTRLSGPDL
610 620 630 640 650
DAVLDRAAAD ARIEPRTSLP YDVEVVRRTG DSGSYLFVIN HTDAEAVVAL
660 670 680
DTPGTELLTG EPAVDKLAVP AGAVRVVRLD G
Length:681
Mass (Da):74,827
Last modified:April 5, 2011 - v1
Checksum:iA9C3C0E8F32B7364
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002475 Genomic DNA. Translation: ADW06353.1.
RefSeqiYP_004925870.1. NC_016114.1.

Genome annotation databases

EnsemblBacteriaiADW06353; ADW06353; Sfla_4952.
GeneIDi11368625.
KEGGisfa:Sfla_4952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002475 Genomic DNA. Translation: ADW06353.1 .
RefSeqi YP_004925870.1. NC_016114.1.

3D structure databases

ProteinModelPortali E8W331.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADW06353 ; ADW06353 ; Sfla_4952 .
GeneIDi 11368625.
KEGGi sfa:Sfla_4952.

Phylogenomic databases

KOi K12308.

Enzyme and pathway databases

BioCyci SFLA591167:GI5Y-5026-MONOMER.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.40.50.880. 1 hit.
InterProi IPR013739. Beta_galactosidase_C.
IPR013738. Beta_galactosidase_Trimer.
IPR029062. Class_I_gatase-like.
IPR003476. Glyco_hydro_42.
IPR013529. Glyco_hydro_42_N.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02449. Glyco_hydro_42. 1 hit.
PF08533. Glyco_hydro_42C. 1 hit.
PF08532. Glyco_hydro_42M. 1 hit.
[Graphical view ]
PIRSFi PIRSF001084. B-galactosidase. 1 hit.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF52317. SSF52317. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33331 / DSM 40990 / IAF-45CDImported.

Entry informationi

Entry nameiE8W331_STRFA
AccessioniPrimary (citable) accession number: E8W331
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 1, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3