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E8W1I5

- E8W1I5_STRFA

UniProt

E8W1I5 - E8W1I5_STRFA

Protein

Elongation factor Tu

Gene

tuf

Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi19 – 268GTPUniRule annotation
    Nucleotide bindingi83 – 875GTPUniRule annotation
    Nucleotide bindingi138 – 1414GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. nucleotidyltransferase activity Source: UniProtKB-KW
    4. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factorUniRule annotationImported, NucleotidyltransferaseImported, Transferase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSFLA591167:GI5Y-2547-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor TuUniRule annotation
    Short name:
    EF-TuUniRule annotation
    Gene namesi
    Name:tufUniRule annotation
    Ordered Locus Names:Sfla_2530Imported
    OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
    Taxonomic identifieri591167 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
    ProteomesiUP000002066: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8W1I5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP-binding elongation factor family. EF-Tu/EF-1A subfamily.UniRule annotation
    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

    Phylogenomic databases

    KOiK02358.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00118_B. EF_Tu_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view]
    PfamiPF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. EFACTOR_GTP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E8W1I5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKAKFERTK PHVNIGTIGH IDHGKTTLTA AITKVLHDAY PDLNEASAFD    50
    QIDKAPEERQ RGITISIAHV EYQTESRHYA HVDCPGHADY IKNMITGAAQ 100
    MDGAILVVAA TDGPMPQTKE HVLLARQVGV PYIVVALNKA DMVDDEEILE 150
    LVELEVRELL SEYEFPGDDL PVVKVSALKA LEGDAEWGKT VLDLMKAVDE 200
    NIPQPERDVE KPFLMPIEDV FTITGRGTVV TGRIERGVLK VNETVDIVGI 250
    KQEKTTTTVT GIEMFRKLLD EGQAGENVGL LLRGIKREDV ERGQVIIKPG 300
    SVTPHTEFQA QAYILSKDEG GRHTPFFNNY RPQFYFRTTD VTGVVTLPEG 350
    TEMVMPGDNT LMDVALIQPV AMEEGLKFAI REGGRTVGAG QVTKIVK 397
    Length:397
    Mass (Da):43,734
    Last modified:April 5, 2011 - v1
    Checksum:i882C0AC6AFFA5073
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002475 Genomic DNA. Translation: ADW03959.1.
    RefSeqiYP_004923476.1. NC_016114.1.

    Genome annotation databases

    EnsemblBacteriaiADW03959; ADW03959; Sfla_2530.
    GeneIDi11368039.
    KEGGisfa:Sfla_2530.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002475 Genomic DNA. Translation: ADW03959.1 .
    RefSeqi YP_004923476.1. NC_016114.1.

    3D structure databases

    ProteinModelPortali E8W1I5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADW03959 ; ADW03959 ; Sfla_2530 .
    GeneIDi 11368039.
    KEGGi sfa:Sfla_2530.

    Phylogenomic databases

    KOi K02358.

    Enzyme and pathway databases

    BioCyci SFLA591167:GI5Y-2547-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00118_B. EF_Tu_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR009001. Transl_elong_EF1A/Init_IF2_C.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    IPR004541. Transl_elong_EFTu/EF1A_bac/org.
    IPR004160. Transl_elong_EFTu/EF1A_C.
    [Graphical view ]
    Pfami PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    PF03143. GTP_EFTU_D3. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF50465. SSF50465. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00485. EF-Tu. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. EFACTOR_GTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 33331 / DSM 40990 / IAF-45CDImported.

    Entry informationi

    Entry nameiE8W1I5_STRFA
    AccessioniPrimary (citable) accession number: E8W1I5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3