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E8W1D4 (E8W1D4_STRFA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201 RuleBase RU004247 SAAS SAAS020622

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201 SAAS SAAS020622

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201 RuleBase RU004247

Sequence similarities

Belongs to the alanine racemase family. HAMAP-Rule MF_01201 RuleBase RU004188

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site661Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2981Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1641Substrate By similarity HAMAP-Rule MF_01201
Binding site3461Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue661N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
E8W1D4 [UniParc].

Last modified April 5, 2011. Version 1.
Checksum: 4EBD432200FE46D4

FASTA41143,170
        10         20         30         40         50         60 
MPSTTGDRLT GHRRSRAQAY GSETLGAMNE TATLRARAEI DLAALRANVR VLRARASGAQ 

        70         80         90        100        110        120 
LMAVVKSDAY GHGAVPCARA AQEAGASWLG TATPQEALAL RAAGIRGRVM CWLWTPGGPW 

       130        140        150        160        170        180 
REAVEADIDV SVSGMWALDE VVAAATEAGI PARIQLKADT GLGRNGCQPA DWPELVSAAR 

       190        200        210        220        230        240 
AAEEAGVLRV TGLWSHFACA DEPGHPSIAA QLDVFRDMVA YAEKEGVRPE VRHIANSPAT 

       250        260        270        280        290        300 
LTVPESHFDL VRTGIAMYGI SPSPELGTSA DFGLRPVMTL AASVALVKQV PPGHGISYGH 

       310        320        330        340        350        360 
HYTTAAETTL ALVPVGYADG IPRHASGRGP VLVGGAVRRI AGRVAMDQFV VDLGGEVLEA 

       370        380        390        400        410 
GAEAVLFGPG DRGEPSAEDW ARAADTIAYE IVTRIGVRVP RVHLHEDSGR D 

« Hide

References

[1]"Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33331 / DSM 40990 / IAF-45CD.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP002475 Genomic DNA. Translation: ADW03908.1.
RefSeqYP_004923425.1. NC_016114.1.

3D structure databases

ProteinModelPortalE8W1D4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADW03908; ADW03908; Sfla_2479.
GeneID11367988.
KEGGsfa:Sfla_2479.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

BioCycSFLA591167:GI5Y-2496-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameE8W1D4_STRFA
AccessionPrimary (citable) accession number: E8W1D4
Entry history
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)