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E8W1D4

- E8W1D4_STRFA

UniProt

E8W1D4 - E8W1D4_STRFA

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Protein
Alanine racemase
Gene
Sfla_2479
Organism
Streptomyces pratensis (strain ATCC 33331 / IAF-45CD)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei164 – 1641Substrate By similarityUniRule annotation
Active sitei298 – 2981Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei346 – 3461Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciSFLA591167:GI5Y-2496-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Sfla_2479Imported
OrganismiStreptomyces pratensis (strain ATCC 33331 / IAF-45CD)Imported
Taxonomic identifieri591167 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces
ProteomesiUP000002066: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliE8W1D4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E8W1D4-1 [UniParc]FASTAAdd to Basket

« Hide

MPSTTGDRLT GHRRSRAQAY GSETLGAMNE TATLRARAEI DLAALRANVR    50
VLRARASGAQ LMAVVKSDAY GHGAVPCARA AQEAGASWLG TATPQEALAL 100
RAAGIRGRVM CWLWTPGGPW REAVEADIDV SVSGMWALDE VVAAATEAGI 150
PARIQLKADT GLGRNGCQPA DWPELVSAAR AAEEAGVLRV TGLWSHFACA 200
DEPGHPSIAA QLDVFRDMVA YAEKEGVRPE VRHIANSPAT LTVPESHFDL 250
VRTGIAMYGI SPSPELGTSA DFGLRPVMTL AASVALVKQV PPGHGISYGH 300
HYTTAAETTL ALVPVGYADG IPRHASGRGP VLVGGAVRRI AGRVAMDQFV 350
VDLGGEVLEA GAEAVLFGPG DRGEPSAEDW ARAADTIAYE IVTRIGVRVP 400
RVHLHEDSGR D 411
Length:411
Mass (Da):43,170
Last modified:April 5, 2011 - v1
Checksum:i4EBD432200FE46D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002475 Genomic DNA. Translation: ADW03908.1.
RefSeqiYP_004923425.1. NC_016114.1.

Genome annotation databases

EnsemblBacteriaiADW03908; ADW03908; Sfla_2479.
GeneIDi11367988.
KEGGisfa:Sfla_2479.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002475 Genomic DNA. Translation: ADW03908.1 .
RefSeqi YP_004923425.1. NC_016114.1.

3D structure databases

ProteinModelPortali E8W1D4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADW03908 ; ADW03908 ; Sfla_2479 .
GeneIDi 11367988.
KEGGi sfa:Sfla_2479.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci SFLA591167:GI5Y-2496-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Streptomyces flavogriseus ATCC 33331."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Davenport K., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Ovchinnikova G., Pagani I., Brumm P., Mead D., Woyke T.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 33331 / DSM 40990 / IAF-45CD.

Entry informationi

Entry nameiE8W1D4_STRFA
AccessioniPrimary (citable) accession number: E8W1D4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: July 9, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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