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E8VNZ5

- E8VNZ5_VIBVM

UniProt

E8VNZ5 - E8VNZ5_VIBVM

Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Vibrio vulnificus (strain MO6-24/O)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (05 Apr 2011)
      Previous versions | rss
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    Functioni

    The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotationSAAS annotation

    Catalytic activityi

    ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW
    3. four-way junction helicase activity Source: InterPro

    GO - Biological processi

    1. DNA recombination Source: UniProtKB-KW
    2. DNA repair Source: UniProtKB-KW
    3. SOS response Source: UniProtKB-KW

    Keywords - Molecular functioni

    HelicaseUniRule annotationSAAS annotationImported, Hydrolase

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-binding, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVVUL914127:GJJH-1099-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
    Gene namesi
    Name:ruvAUniRule annotation
    Ordered Locus Names:VVMO6_01026Imported
    OrganismiVibrio vulnificus (strain MO6-24/O)Imported
    Taxonomic identifieri914127 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000006905: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. Holliday junction helicase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a complex with RuvB.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliE8VNZ5.
    SMRiE8VNZ5. Positions 1-202.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RuvA family.UniRule annotation

    Phylogenomic databases

    KOiK03550.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_00031. DNA_helic_RuvA.
    InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view]
    PfamiPF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view]
    SMARTiSM00278. HhH1. 2 hits.
    [Graphical view]
    SUPFAMiSSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00084. ruvA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E8VNZ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIGRLRGILL EKQPPELLIE VNGIGYEVQM PMSCFYELPN IGEEAIIYTH    50
    FVVREDAQLL YGFNTVKERA LFREVIKANG VGPKLGLAIL SGMTASQFVA 100
    SVEREDISTL VKLPGVGKKT AERLVVEMKD RLKGWSAGDL FTPFTDAAPV 150
    DSGSTSSNSA EEEAVSALLA LGYKPVQASK VVSQIAKPDM TSEQLIREAL 200
    KSMV 204
    Length:204
    Mass (Da):22,205
    Last modified:April 5, 2011 - v1
    Checksum:i3256FAECAD1EC08B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002469 Genomic DNA. Translation: ADV86048.1.
    RefSeqiWP_011080038.1. NC_014965.1.
    YP_004188251.1. NC_014965.1.

    Genome annotation databases

    EnsemblBacteriaiADV86048; ADV86048; VVMO6_01026.
    GeneIDi10165794.
    KEGGivvm:VVMO6_01026.
    PATRICi47050077. VBIVibVul176069_1024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002469 Genomic DNA. Translation: ADV86048.1 .
    RefSeqi WP_011080038.1. NC_014965.1.
    YP_004188251.1. NC_014965.1.

    3D structure databases

    ProteinModelPortali E8VNZ5.
    SMRi E8VNZ5. Positions 1-202.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADV86048 ; ADV86048 ; VVMO6_01026 .
    GeneIDi 10165794.
    KEGGi vvm:VVMO6_01026.
    PATRICi 47050077. VBIVibVul176069_1024.

    Phylogenomic databases

    KOi K03550.

    Enzyme and pathway databases

    BioCyci VVUL914127:GJJH-1099-MONOMER.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_00031. DNA_helic_RuvA.
    InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
    IPR013849. DNA_helicase_Holl-junc_RuvA_I.
    IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
    IPR012340. NA-bd_OB-fold.
    IPR000085. RuvA.
    IPR010994. RuvA_2-like.
    [Graphical view ]
    Pfami PF07499. RuvA_C. 1 hit.
    PF01330. RuvA_N. 1 hit.
    [Graphical view ]
    SMARTi SM00278. HhH1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46929. SSF46929. 1 hit.
    SSF47781. SSF47781. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00084. ruvA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MO6-24/OImported.

    Entry informationi

    Entry nameiE8VNZ5_VIBVM
    AccessioniPrimary (citable) accession number: E8VNZ5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: April 5, 2011
    Last sequence update: April 5, 2011
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3