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E8VNZ5

- E8VNZ5_VIBVM

UniProt

E8VNZ5 - E8VNZ5_VIBVM

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Protein

Holliday junction ATP-dependent DNA helicase RuvA

Gene

ruvA

Organism
Vibrio vulnificus (strain MO6-24/O)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.UniRule annotationSAAS annotation

Catalytic activityi

ATP + H2O = ADP + phosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: UniProtKB-KW
  3. four-way junction helicase activity Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-KW
  2. DNA repair Source: UniProtKB-KW
  3. SOS response Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotationSAAS annotation, Hydrolase

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-binding, DNA-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciVVUL914127:GJJH-1099-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Holliday junction ATP-dependent DNA helicase RuvAUniRule annotation (EC:3.6.4.12UniRule annotation)
Gene namesi
Name:ruvAUniRule annotation
Ordered Locus Names:VVMO6_01026Imported
OrganismiVibrio vulnificus (strain MO6-24/O)Imported
Taxonomic identifieri914127 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000006905: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. Holliday junction helicase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Forms a complex with RuvB.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliE8VNZ5.
SMRiE8VNZ5. Positions 1-202.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvA family.UniRule annotation

Phylogenomic databases

KOiK03550.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00031. DNA_helic_RuvA.
InterProiIPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view]
PfamiPF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view]
SMARTiSM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMiSSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00084. ruvA. 1 hit.

Sequencei

Sequence statusi: Complete.

E8VNZ5 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIGRLRGILL EKQPPELLIE VNGIGYEVQM PMSCFYELPN IGEEAIIYTH
60 70 80 90 100
FVVREDAQLL YGFNTVKERA LFREVIKANG VGPKLGLAIL SGMTASQFVA
110 120 130 140 150
SVEREDISTL VKLPGVGKKT AERLVVEMKD RLKGWSAGDL FTPFTDAAPV
160 170 180 190 200
DSGSTSSNSA EEEAVSALLA LGYKPVQASK VVSQIAKPDM TSEQLIREAL

KSMV
Length:204
Mass (Da):22,205
Last modified:April 5, 2011 - v1
Checksum:i3256FAECAD1EC08B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002469 Genomic DNA. Translation: ADV86048.1.
RefSeqiWP_011080038.1. NC_014965.1.
YP_004188251.1. NC_014965.1.

Genome annotation databases

EnsemblBacteriaiADV86048; ADV86048; VVMO6_01026.
GeneIDi10165794.
KEGGivvm:VVMO6_01026.
PATRICi47050077. VBIVibVul176069_1024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002469 Genomic DNA. Translation: ADV86048.1 .
RefSeqi WP_011080038.1. NC_014965.1.
YP_004188251.1. NC_014965.1.

3D structure databases

ProteinModelPortali E8VNZ5.
SMRi E8VNZ5. Positions 1-202.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADV86048 ; ADV86048 ; VVMO6_01026 .
GeneIDi 10165794.
KEGGi vvm:VVMO6_01026.
PATRICi 47050077. VBIVibVul176069_1024.

Phylogenomic databases

KOi K03550.

Enzyme and pathway databases

BioCyci VVUL914127:GJJH-1099-MONOMER.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_00031. DNA_helic_RuvA.
InterProi IPR011114. DNA_helicas_Holl-junc_RuvA_C.
IPR013849. DNA_helicase_Holl-junc_RuvA_I.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR012340. NA-bd_OB-fold.
IPR000085. RuvA.
IPR010994. RuvA_2-like.
[Graphical view ]
Pfami PF07499. RuvA_C. 1 hit.
PF01330. RuvA_N. 1 hit.
[Graphical view ]
SMARTi SM00278. HhH1. 2 hits.
[Graphical view ]
SUPFAMi SSF46929. SSF46929. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00084. ruvA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MO6-24/OImported.

Entry informationi

Entry nameiE8VNZ5_VIBVM
AccessioniPrimary (citable) accession number: E8VNZ5
Entry historyi
Integrated into UniProtKB/TrEMBL: April 5, 2011
Last sequence update: April 5, 2011
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3